Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jacqueline Rosains"'
Autor:
Jacqueline Rosains, Susan E Mango
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49490 (2012)
The nonsense mediated decay (NMD) pathway degrades mRNAs bearing premature translation termination codons. In mammals, SMG-8 has been implicated in the NMD pathway, in part by its association with SMG-1 kinase. Here we use four independent assays to
Externí odkaz:
https://doaj.org/article/a6c918e0192640a0babb7bbbb1695cf6
Autor:
Anuj Srivastava, Shunqiang Li, Brian A. Van Tine, Christian Frech, Carol J. Bult, Rajesh Patidar, Vito W. Rebecca, Jeffrey S. Morris, Michael Davies, Huiqin Chen, Sasi Arunachalam, Jeffrey A. Moscow, Ramaswamy Govindan, Jayamanna Wickramasinghe, Zi-Ming Zhao, James H. Doroshow, Adam Stanojevic, Dennis A. Dean, Funda Meric-Bernstam, Jacqueline Rosains, Michael T. Lewis, Bryan E. Welm, Min Xiao, Jelena Randjelovic, Sherri R. Davies, Lily Chen, Brandi N. Davis-Dusenbery, David A. Nix, Meenhard Herlyn, Li Ding, Jack DiGiovanna, Xing Yi Woo, Jack A. Roth, Min Jin Ha, Steven B. Neuhauser, Ryan Jeon, Peter N. Robinson, Bingliang Fang, Michael Lloyd, Tamara Stankovic, Jeffrey H. Chuang, Yvonne A. Evrard, Nevena Miletic, Alana L. Welm, Isheeta Seth, Andrew V. Kossenkov
Patient-Derived Xenografts (PDXs) are tumor-in-mouse models for cancer. PDX collections, such as those supported by the NCI PDXNet program, are powerful resources for preclinical therapeutic testing. However, variations in experimental design and ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d794ae70d4df8d622038bee00d4f9768
https://doi.org/10.1101/790246
https://doi.org/10.1101/790246
Autor:
Michael Lloyd, R. Jay Mashl, Yvonne A. Evrard, Jeffrey A. Moscow, Jong Il Kim, Alana L. Welm, Michael A. Davies, Carol J. Bult, Jayamanna Wickramasinghe, Rania El Botty, Dennis A. Dean, Jessica Giordano, Anuj Srivastava, Sandra D. Scherer, Jacqueline Rosains, Christian Frech, Elisabetta Marangoni, Jeffrey H. Chuang, Ryan Jeon, Shunqiang Li, Matthew H. Bailey, Yun-Suhk Suh, Elodie Modave, Yuanxin Xi, Enzo Medico, Li Ding, Livio Trusolino, Adam Lafferty, Vito W. Rebecca, Han-Kwang Yang, Jing Wang, Annette T. Byrne, Xing Yi Woo, Alice C. O’Farrell, Claudio Isella, Li Chen, Brandi N. Davis-Dusenbery, James H. Doroshow, Sherri R. Davies, Diether Lambrechts, Jos Jonkers, Bingliang Fang, Charles Lee, Roebi de Bruijn, Violeta Serra, Jack A. Roth, Rajesh Patidar, Funda Meric-Bernstam, Petra ter Brugge, Andrew V. Kossenkov, Hyun-Soo Kim, Andrea Bertotti, Emilio Cortes-Sanchez, Chieh-Hsiang Yang, Ramaswamy Govindan, Francesco Galimi, Jelena Randjelovic, Zi-Ming Zhao, Bryan E. Welm, Hua Sun, Meenhard Herlyn, Michael T. Lewis
Publikováno v:
Nature Genetics
Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, affecting the ac
Autor:
Joshua Gould, Anita Vrcic, Alykhan F. Shamji, Bina Julian, Jacqueline Rosains, Ian Smith, Mariya Khan, Federica Piccioni, Stuart L. Schreiber, Wen-Ning Zhao, Jacob K. Asiedu, Xiaodong Lu, Stephen J. Haggarty, Justin Lamb, David L. Lahr, John F. Davis, Arthur Liberzon, Nathanael S. Gray, Courtney Toder, Andrew A. Tubelli, Corey Flynn, Willis Read-Button, Lucienne Ronco, David E. Root, Kristin Ardlie, Alice H. Berger, Marek Orzechowski, David Wadden, Mukta Bagul, Zihan Liu, Aravind Subramanian, Angela N. Brooks, Rajiv Narayan, Xiaohua Wu, Serena J. Silver, Daniel D. Lam, David Y. Takeda, Xiaoyun Wu, Desiree Davison, Todd R. Golub, Oana M. Enache, Paul A. Clemons, Bang Wong, Melanie Donahue, Steven M. Corsello, Ted Natoli, David Peck, Jodi E. Hirschman, Larson Hogstrom, Jesse S. Boehm, John G. Doench, Joshua A. Bittker
SUMMARYWe previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs and disease states are connected by virtue of common gene-expression signatures. Here, we report more than a 1,000-fold scale-up of the CMap as part of the NI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50052c08c8737070100283e39ac07b63
Autor:
Courtney Toder, Jodi E. Hirschman, Oana M. Enache, Larson Hogstrom, Kristin Ardlie, Ian Smith, David E. Root, Sarah A. Johnson, David L. Lahr, Bina Julian, David Wadden, Jesse S. Boehm, Nathanael S. Gray, Mariya Khan, John G. Doench, Nicholas J. Lyons, David Y. Takeda, John F. Davis, Mukta Bagul, Melanie Donahue, David Peck, Aravind Subramanian, Anita Vrcic, Desiree Davison, Steven M. Corsello, Xiaoyun Wu, Alice H. Berger, Wen-Ning Zhao, Bang Wong, Lucienne Ronco, Serena J. Silver, Willis Read-Button, Marek Orzechowski, Rajiv Narayan, Ted Natoli, Federica Piccioni, Stephen J. Haggarty, Zihan Liu, Stuart L. Schreiber, Jacqueline Rosains, Jacob K. Asiedu, Angela N. Brooks, Xiaodong Lu, Daniel D. Lam, Arthur Liberzon, Peyton Greenside, Corey Flynn, Joshua Gould, Justin Lamb, Alykhan F. Shamji, Xiaohua Wu, Joshua A. Bittker, Roger Hu, Andrew A. Tubelli, Todd R. Golub, Paul A. Clemons
Publikováno v:
Cell, vol 171, iss 6
We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures. Here, we report more than a 1,000-fold scale-up of the CMap as part of the NIH LINC
Autor:
Jacqueline Rosains, Anuj Srivastava, Wingyi Woo, Vishal Sarsani, ZiMing Zhao, Javad Noorbakhsh, Ogan D. Abaan, Christian Frech, Jack DiGiovanna, Ryan Jeon, Steve Neuhauser, Peter Robinson, Yvonne A. Evrard, Carol Bult, Jeffrey A. Moscow, Brandi Davis-Dusenbery, Jeffrey H. Chuang
Publikováno v:
Cancer Research. 79:1074-1074
Patient-Derived Xenografts (PDX) are proven models to study novel drugs or drug combinations and test hypothesis in preclinical studies. The overarching goal of the PDXNet is to coordinate the development of appropriate PDX models and methods for pre
Autor:
Joel N. H. Stern, Jeff W. Lichtman, Alan B. Lenarcic, José Rivera-Feliciano, Inna Tabansky, Derin B. Keskin, Karine Loulier, Jean Livet, Kevin Eggan, Jacqueline Rosains, Joshua R. Sanes
Publikováno v:
Current Biology. 23:21-31
Summary Background The cleavage-stage mouse embryo is composed of superficially equivalent blastomeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (TE). However, it remains unsettled whether the contri
Publikováno v:
Nature. 447:679-685
Until now, animal cloning and the production of embryonic stem cell lines by somatic cell nuclear transfer have relied on introducing nuclei into meiotic oocytes. In contrast, attempts at somatic cell nuclear transfer into fertilized interphase zygot
Autor:
Katherine A. Fitzgerald, Jacqueline Rosains, Sarah M. McWhirter, Douglas T. Golenbock, Daniel C. Rowe, Tom Maniatis
Publikováno v:
Proceedings of the National Academy of Sciences. 101:233-238
Virus infection, double-stranded RNA, and lipopolysaccharide each induce the expression of genes encoding IFN-α and -β and chemokines, such as RANTES (regulated on activation, normal T cell expressed and secreted) and IP-10 (IFN-γ inducible protei
Autor:
Susan E. Mango, Jacqueline Rosains
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49490 (2012)
PLoS ONE
PLoS ONE
The nonsense mediated decay (NMD) pathway degrades mRNAs bearing premature translation termination codons. In mammals, SMG-8 has been implicated in the NMD pathway, in part by its association with SMG-1 kinase. Here we use four independent assays to