Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jacqueline R. Kulbe"'
Autor:
Bryant Avalos, Jacqueline R. Kulbe, Mary K. Ford, Anna Elizabeth Laird, Kyle Walter, Michael Mante, Jazmin B. Florio, Ali Boustani, Antoine Chaillon, Johannes C. M. Schlachetzki, Erin E. Sundermann, David J. Volsky, Robert A. Rissman, Ronald J. Ellis, Scott L. Letendre, Jennifer Iudicello, Jerel Adam Fields
Publikováno v:
Viruses, Vol 16, Iss 10, p 1509 (2024)
Triggering receptor expressed on myeloid cells 2 (TREM2) is involved in neuroinflammation and HIV-associated neurocognitive impairment (NCI). People with HIV (PWH) using cannabis exhibit lower inflammation and neurological disorders. We hypothesized
Externí odkaz:
https://doaj.org/article/4d637d679e76456dbcdd30adf98db292
Autor:
Edward D. Hall, Jacqueline R. Kulbe
Publikováno v:
Progress in Neurobiology. 158:15-44
In recent years, a new neurodegenerative tauopathy labeled Chronic Traumatic Encephalopathy (CTE), has been identified that is believed to be primarily a sequela of repeated mild traumatic brain injury (TBI), often referred to as concussion, that occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95d41485bf6899c159c12dfa9671b6f
https://doi.org/10.1016/j.pneurobio.2017.08.003
https://doi.org/10.1016/j.pneurobio.2017.08.003
Publikováno v:
Exp Neurol
Traumatic brain injury (TBI) results in mitochondrial dysfunction and induction of lipid peroxidation (LP). Lipid peroxidation-derived neurotoxic aldehydes such as 4-HNE and acrolein bind to mitochondrial proteins, inducing additional oxidative damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecaa733e2178a23c1edaa005fe89ef7e
https://pubmed.ncbi.nlm.nih.gov/32325157
https://pubmed.ncbi.nlm.nih.gov/32325157
To date, all monotherapy clinical traumatic brain injury (TBI) trials have failed, and there are currently no Food and Drug Administration (FDA)-approved pharmacotherapies for the acute treatment of severe TBI. Due to the complex secondary injury cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9586fefa71fdef5773e0fe2d28d2a047
https://europepmc.org/articles/PMC5962911/
https://europepmc.org/articles/PMC5962911/
Publikováno v:
Neuroscience. 386
Traumatic brain injury (TBI) results in mitochondrial dysfunction and induction of lipid peroxidation (LP). Lipid peroxidation-derived neurotoxic aldehydes such as 4-HNE and acrolein bind to mitochondrial proteins, inducing additional oxidative damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd3f3259f88f76fa8ef154273504f04
https://pubmed.ncbi.nlm.nih.gov/29960045
https://pubmed.ncbi.nlm.nih.gov/29960045
Currently, there are no Food and Drug Administration (FDA)-approved pharmacotherapies for the treatment of those with traumatic brain injury (TBI). As central mediators of the secondary injury cascade, mitochondria are promising therapeutic targets f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbbdd8407e9acfebf8761b216e6847e
https://europepmc.org/articles/PMC5385586/
https://europepmc.org/articles/PMC5385586/
Autor:
Juan A. Wang, Jacqueline R. Kulbe, Indrapal N. Singh, Rachel L. Hill, John E. Cebak, Edward D. Hall
Reactive oxygen-induced lipid peroxidation (LP) has been documented to play a critical role in pathophysiology, neurodegeneration, and neurological disability that follows acute traumatic brain injury (TBI) and spinal cord injury (SCI). Consistent wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ecc5157f421802b0677fd929f01d91
https://doi.org/10.1016/b978-0-12-802686-1.00013-4
https://doi.org/10.1016/b978-0-12-802686-1.00013-4
Autor:
K. Ulrich Bayer, Steven J. Coultrap, Tim A. Benke, Isabelle Buard, Kelsey Barcomb, Heather O'Leary, Jacqueline R. Kulbe
Publikováno v:
The FASEB Journal. 28:3810-3819
A hallmark feature of Ca 2 /calmodulin (CaM)-dependent protein kinase II (CaMKII) is gener- ation of autonomous (Ca 2 -independent) activity by T286 autophosphorylation. Biochemical studies have shown that "autonomous" CaMKII is 5-fold further stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70c255b15c7cde2eb639610591fa00e
https://doi.org/10.1096/fj.14-250407
https://doi.org/10.1096/fj.14-250407
Autor:
Andrew Thorburn, Jacqueline R. Kulbe, Jean M. Mulcahy Levy, K. Ulrich Bayer, Steven J. Coultrap
Publikováno v:
Brain Research. 1542:12-19
Excitotoxic insults such as cerebral ischemia are thought to enhance neuronal autophagy, which is then thought to promote neuronal cell death. Excitotoxic insults indeed increase autophagy markers. Notably, however, autophagy markers can be increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae39bd65873c3624d5ec357501bbe25
https://doi.org/10.1016/j.brainres.2013.10.032
https://doi.org/10.1016/j.brainres.2013.10.032
Autor:
James W. Geddes, Jacqueline R. Kulbe
Publikováno v:
Experimental neurology.
Mild traumatic brain injury (mTBI) affects millions of people annually and is difficult to diagnose. Mild injury is insensitive to conventional imaging techniques and diagnoses are often made using subjective criteria such as self-reported symptoms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661524832739d73ae8be18850f0fcbdd
https://pubmed.ncbi.nlm.nih.gov/25981889
https://pubmed.ncbi.nlm.nih.gov/25981889