Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jacqueline Plowman"'
Autor:
Chii M. Lin, Hui Kang Wang, Ernest Hamel, Jacqueline Plowman, Kuo Hsiung Lee, Kenneth D. Paull
Publikováno v:
Biochemical Pharmacology. 51:53-59
A series of derivatives of 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone (DHQZ) with known antitumor activity was re-evaluated in the National Cancer Institute cancer cell line screen. Analysis by the COMPARE algorithm suggested that their cytotoxicity de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa3463dd1bc62f3a467c313c3dc88423
https://doi.org/10.1016/0006-2952(95)02156-6
https://doi.org/10.1016/0006-2952(95)02156-6
Autor:
Jacqueline Plowman, D. M. Houston, V. L. Narayanan, R. D. Haugwitz, Yueh-Sha Wang, Wayne K. Anderson, Ravindra Kasliwal
Publikováno v:
Journal of Medicinal Chemistry. 38:3789-3797
Platinum (II) and platinum (IV) coordination complexes derived from beta-silyl-substituted amines were prepared. The solubility of selected complexes in water and physiological saline was measured, and the effect of the beta-silicon on the reactivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343fd9f223510978e29e91e77a17b6ba
https://doi.org/10.1021/jm00019a008
https://doi.org/10.1021/jm00019a008
Autor:
Jacqueline Plowman, Oystein Fodstad, H. C.Dreef van Der Meulen, H.R. Hendriks, R. E.C. Henrar, K. D. Paull, H. M. Pinedo, Heinz H. Fiebig, Dietmar P. Berger, G. Schwartsman
Publikováno v:
Annals of Oncology, 3(9), 755-763. Oxford University Press
Hendriks, H R, Plowman, J, Berger, D P, Paull, K D, Fiebig, H H, Fodstad, O, Dreef-Van der Meulen, H C, Henrar, R E C, Pinedo, H M & Schwartsmann, G 1992, ' Preclinical antitumour activity and animal toxicology studies of rhizoxin, a novel tubulin-interacting agent ', Annals of Oncology, vol. 3, no. 9, pp. 755-763 .
Hendriks, H R, Plowman, J, Berger, D P, Paull, K D, Fiebig, H H, Fodstad, O, Dreef-Van der Meulen, H C, Henrar, R E C, Pinedo, H M & Schwartsmann, G 1992, ' Preclinical antitumour activity and animal toxicology studies of rhizoxin, a novel tubulin-interacting agent ', Annals of Oncology, vol. 3, no. 9, pp. 755-763 .
Rhizoxin is a 16-membered antifungal macrocyclic lactone isolated from the plant pathogenic fungus Rhizopus chinensis. The compound binds to tubulin, preventing microtubule formation, and inhibiting mitosis. It possesses antitumour activity in vivo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13590cc38b81dca7d055b7a361c92e13
https://doi.org/10.1093/oxfordjournals.annonc.a058334
https://doi.org/10.1093/oxfordjournals.annonc.a058334
Autor:
Jacqueline Plowman, John S. Driscoll, Victor E. Marquez, Joseph J. Barchi, James A. Kelley, Paul S. Liu
Publikováno v:
Journal of Medicinal Chemistry. 34:3280-3284
2(1H)-Pyrimidinone riboside (zebularine, 1b) and its 5-fluoro (6b) and 2'-ara-fluoro (7b) analogues have been synthesized and evaluated in vivo as antitumor agents. Zebularine provides increase in life span (ILS) values of ca. 70% against intraperito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79576a0a7c1c687ad87129e2a3913c98
https://doi.org/10.1021/jm00115a017
https://doi.org/10.1021/jm00115a017
Publikováno v:
Investigational New Drugs. 9:295-303
Terephthalamidine (NSC 57155) (Fig. 1) is one of 800 terephthalanilides and related compounds which were synthesized and tested preclinically in the late 1950's and early 1960's. Based upon their activity against murine leukemias, some of these agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f19f2a4a6492d1c28ffb7b17e3bcf8
https://doi.org/10.1007/bf00183569
https://doi.org/10.1007/bf00183569
Publikováno v:
Cancer Chemotherapy and Pharmacology. 25:425-429
Pyrazine diazohydroxide (sodium salt, NSC 361456; PZDH) is a new antitumor drug with relatively broad activity in initial evaluations against murine leukemias, solid tumors, and two human tumor xenografts in vivo. The present studies were designed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41228983da6cc55b8518acf0fdb49996
https://doi.org/10.1007/bf00686053
https://doi.org/10.1007/bf00686053
Autor:
Melissa A. Reardon, May S. Lui, Jacqueline Plowman, Konrad Pillwein, Hiremagalur N. Jayaram, William L. Elliott, George Weber
Publikováno v:
Cancer Chemotherapy and Pharmacology. 26:88-92
A study on the oncolytic activity of the L-cysteine derivative L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride (NSC 303861), revealed that the drug caused complete regression of the MX-1 human mammary tumor xenograft. The compound al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3082ce752c83c80e5ed1b228bd6bba
https://doi.org/10.1007/bf02897250
https://doi.org/10.1007/bf02897250
Autor:
Emily Stowe, David A. Cooney, Katherine A. Dobyns, John S. Driscoll, Joseph O. Anderson, Zhang Hao, Michael E. Rommel, Harry Ford, William R. Waud, David G. Johns, Jacqueline Plowman
Publikováno v:
Biochemical pharmacology. 49(2)
Among nine compounds surveyed, cytidine was found to be the most effective in reversing the antiproliferative effects of cyclopentenyl cytosine (CPEC) on human T-lymphoblasts (MOLT-4) in culture. Cytidine, at concentrations of 1-25 microM, enabled ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dceec839da89fde01cfaf0d449994094
https://pubmed.ncbi.nlm.nih.gov/7840794
https://pubmed.ncbi.nlm.nih.gov/7840794
Autor:
Adaline C. Smith, Blaire L. Osborn, Jason S. Fisherman, Robert H. Shoemaker, Hoo G. Chun, Daniel S. Zaharko, Jacqueline Plowman, Michaele C. Christian
Publikováno v:
Investigational new drugs. 11(1)
Chloroquinoxaline sulfonamide (CQS) has been developed to the clinical trial stage based on its activity in the Human Tumor Colony Forming Assay (HTCFA). In the HTCFA, CQS demonstrated inhibition of colony formation against breast, lung, melanoma and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4cc6add7cec0291e73728d991b1b0a
https://pubmed.ncbi.nlm.nih.gov/8349430
https://pubmed.ncbi.nlm.nih.gov/8349430
Autor:
Wayne K. Anderson, William R. Waud, Steadman D. Harrison, Jacqueline Plowman, Donald J. Dykes, Griswold Dp
Publikováno v:
Cancer chemotherapy and pharmacology. 30(4)
Carmethizole hydrochloride [1-methyl-2-methylthio-4,5-bis(hydroxymethyl)imidazole-4', 5'-bis(N-methylcarbamate)hydrochloride, NSC 602,668; hereafter called carmethizole] is a new antitumor drug that has shown relatively broad activity in initial eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba83ebcbb5a2e20859e25c514db0a30
https://pubmed.ncbi.nlm.nih.gov/1322803
https://pubmed.ncbi.nlm.nih.gov/1322803