Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jacqueline Panigel"'
Autor:
James Z. Deng, Amy Calamari, Samuel L. Graham, Christopher S. Burgey, Eric L. Moore, Craig M. Potteiger, Jixin Wang, Carolyn Segerdell, Daniel V. Paone, James Mulhearn, Cuyue Tang, Diem N. Nguyen, Kerry L. Fillgrove, Shaun R. Stauffer, Michael D. Leitl, Annie Liang, Mark O. Urban, Anthony Ginnetti, Gong Cheng, Anthony W. Shaw, Stefanie A. Kane, Jacqueline Panigel, Christopher A. Salvatore, Sean P. Cook, Juliana Anquandah
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1392-1396
A second-generation small molecule P2X3 receptor antagonist has been developed. The lead optimization strategy to address shortcomings of the first-generation preclinical lead compound is described herein. These studies were directed towards the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9a5d8b32ff27b4abbd55923273b1fb
https://doi.org/10.1016/j.bmcl.2018.02.039
https://doi.org/10.1016/j.bmcl.2018.02.039
Autor:
Andrea K. Houghton, Aneta Jovanovska, Tracey Filzen, Ying-Hong Wang, Jacqueline Panigel, Annie Liang, Michelle K. Clements, Rebecca M. Klein, Richard L. Kraus, John Majercak, Eleftheria N. Finger, Jixin Wang, Matthew J. Cato, Hannah D. G. F. Lehman, Christopher Daley, Yun Gregan, James Mulhearn, Yuxing Li, Michael A. Rossi, Darrell A. Henze, Mark O. Urban, Michael J. Kelly, Scott E. Wolkenberg, Mark E. Layton, Joseph E. Pero
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2683-2688
Studies on human genetics have suggested that inhibitors of the Nav1.7 voltage-gated sodium channel hold considerable promise as therapies for the treatment of chronic pain syndromes. Herein, we report novel, peripherally-restricted benzoxazolinone a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa8cc863252cd7ed266d6ff8eb35f8f
https://doi.org/10.1016/j.bmcl.2017.04.040
https://doi.org/10.1016/j.bmcl.2017.04.040
Autor:
Mark E. Layton, Eleftheria N. Finger, Edward C. Sherer, Amy Jo Koser, Aneta Jovanovska, Robert Gomez, Xiu Wang, Deping Wang, Xuanjia Peng, John Majercak, Melissa Egbertson, Paul J. Coleman, Rebecca M. Klein, Kristen L.G. Jones, Richard L. Kraus, Jixin Wang, Tracey Filzen, Mark O. Urban, Yuxing Li, Anthony J. Roecker, Matthew J. Cato, Ying-Hong Wang, Michelle K. Clements, Jacqueline Panigel, Leo A. Joyce, Vincent P. Santarelli, Irene Gregan, Christopher Daley, Haiyan Sun, Andrea K. Houghton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2087-2093
The voltage-gated sodium channel Nav1.7 is a genetically validated target for the treatment of pain with gain-of-function mutations in man eliciting a variety of painful disorders and loss-of-function mutations affording insensitivity to pain. Unfort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6460ec06d229cf43b30709ab80de83e3
https://doi.org/10.1016/j.bmcl.2017.03.085
https://doi.org/10.1016/j.bmcl.2017.03.085
Autor:
Anthony J, Roecker, Melissa, Egbertson, Kristen L G, Jones, Robert, Gomez, Richard L, Kraus, Yuxing, Li, Amy Jo, Koser, Mark O, Urban, Rebecca, Klein, Michelle, Clements, Jacqueline, Panigel, Christopher, Daley, Jixin, Wang, Eleftheria N, Finger, John, Majercak, Vincent, Santarelli, Irene, Gregan, Matthew, Cato, Tracey, Filzen, Aneta, Jovanovska, Ying-Hong, Wang, Deping, Wang, Leo A, Joyce, Edward C, Sherer, Xuanjia, Peng, Xiu, Wang, Haiyan, Sun, Paul J, Coleman, Andrea K, Houghton, Mark E, Layton
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(10)
The voltage-gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9bbd5306725778e4f9bb0907a6353e2
https://pubmed.ncbi.nlm.nih.gov/28389149
https://pubmed.ncbi.nlm.nih.gov/28389149
Autor:
Joseph E, Pero, Michael A, Rossi, Hannah D G F, Lehman, Michael J, Kelly, James J, Mulhearn, Scott E, Wolkenberg, Matthew J, Cato, Michelle K, Clements, Christopher J, Daley, Tracey, Filzen, Eleftheria N, Finger, Yun, Gregan, Darrell A, Henze, Aneta, Jovanovska, Rebecca, Klein, Richard L, Kraus, Yuxing, Li, Annie, Liang, John M, Majercak, Jacqueline, Panigel, Mark O, Urban, Jixin, Wang, Ying-Hong, Wang, Andrea K, Houghton, Mark E, Layton
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(12)
Studies on human genetics have suggested that inhibitors of the Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::778a3d26f8386c5f7b36bf25f166c4da
https://pubmed.ncbi.nlm.nih.gov/28465103
https://pubmed.ncbi.nlm.nih.gov/28465103
Autor:
Sean P. Cook, Jacqueline Panigel
Publikováno v:
Journal of neurogenetics. 25(4)
Voltage-gated sodium channels (VGSC) contribute to the initiation and propagation of action potentials within the nervous system. These channels are important targets for inhibition by several classes of drugs, including antiarrhythmics and local ane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f7bfe5e1640a3cf322ce8d4948631a
https://pubmed.ncbi.nlm.nih.gov/22074404
https://pubmed.ncbi.nlm.nih.gov/22074404
Autor:
James Mulhearn, Matthew J. Cato, Darrell A. Henze, Jacqueline Panigel, John M. Sanders, James C. Barrow, George D. Hartman, Zhijian Zhao, Aneta Jovanovska, Scott E. Wolkenberg, Sean P. Cook, Scott T. Harrison, Stefanie A. Kane
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(9)
The Merck Fragment Library was screened versus acid-sensing ion channel 3 (ASIC3), a novel target for the treatment of pain. Fragment hits were optimized using two strategies, and potency was improved from 0.7 mM to 3 μM with retention of good ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1a0c94264b9b34c9068c8e08358ae5
https://pubmed.ncbi.nlm.nih.gov/21257308
https://pubmed.ncbi.nlm.nih.gov/21257308