Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jacqueline N. Williams"'
Autor:
Arun K. Ghosh, Jacqueline N. Williams, Rachel Y. Ho, Hannah M. Simpson, Shin-ichiro Hattori, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Irene T. Weber, Hiroaki Mitsuya
Publikováno v:
Journal of Medicinal Chemistry. 61:9722-9737
We have designed, synthesized, and evaluated a new class of potent HIV-1 protease inhibitors with novel bicyclic oxazolidinone derivatives as the P2 ligand. We have developed an enantioselective synthesis of these bicyclic oxazolidinones utilizing a
Autor:
Arun K. Ghosh, D. Eric Walters, Jacqueline N. Williams, Hannah M. Simpson, Jun Takayama, Satish Kovela, Manabu Aoki, Hiroaki Mitsuya, Shin-ichiro Hattori
Publikováno v:
Bioorg Med Chem Lett
We describe the design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors containing a squaramide-derived scaffold as the P2 ligand in combination with a (R)-hydroxyethylamine sulfonamide isostere. Inhibitor 3h with an N-methyl-
Dissertation/ Thesis
In 2018, the World Health Organization (WHO) reported approximately 37 million people are living with the Human Immunodeficiency Virus (HIV). Suppressing replication of the virus down to undetectable levels was achieved by combination antiretroviral