Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jacqueline Mock"'
A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors
Autor:
Giulia Rotta, Ettore Gilardoni, Domenico Ravazza, Jacqueline Mock, Frauke Seehusen, Abdullah Elsayed, Emanuele Puca, Roberto De Luca, Christian Pellegrino, Thomas Look, Tobias Weiss, Markus G Manz, Cornelia Halin, Dario Neri, Sheila Dakhel Plaza
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 904-926 (2024)
Abstract Cytokine-based therapeutics have been shown to mediate objective responses in certain tumor entities but suffer from insufficient selectivity, causing limiting toxicity which prevents dose escalation to therapeutically active regimens. The a
Externí odkaz:
https://doaj.org/article/3f9295ee87c944c5ae3975d61e53a157
Autor:
Abdullah Elsayed, Christian Pellegrino, Louis Plüss, Frederik Peissert, Ramon Benz, Franziska Ulrich, Gudrun Thorhallsdottir, Sheila Dakhel Plaza, Alessandra Villa, Jacqueline Mock, Emanuele Puca, Roberto De Luca, Markus G. Manz, Cornelia Halin, Dario Neri
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody-based therapeutics represent an important class of biopharmaceuticals in cancer immunotherapy. CD3 bispecific T-cell engagers activate cytotoxic T-cells and have shown remarkable clinical outcomes against several hematological malign
Externí odkaz:
https://doaj.org/article/0deae8b2479a4c3eace1b463b64d5b8f
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Engineered cytokine products represent a growing class of therapeutic proteins which need to be tested for biological activity at various stages of pharmaceutical development. In most cases, dedicated biological assays are established for di
Externí odkaz:
https://doaj.org/article/24f36847b7134e45b1c03f29bc469dc3
Autor:
Cesare Di Nitto, Ettore Gilardoni, Jacqueline Mock, Lisa Nadal, Tobias Weiss, Michael Weller, Frauke Seehusen, Chiara Libbra, Emanuele Puca, Dario Neri, Roberto De Luca
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 377 (2023)
Interferon-gamma (IFNγ) is one of the central cytokines produced by the innate and adaptive immune systems. IFNγ directly favors tumor growth control by enhancing the immunogenicity of tumor cells, induces IP-10 secretion facilitating (CXCR3+) immu
Externí odkaz:
https://doaj.org/article/5069da7f3bae4690a2dfe75a2185f9f7
Autor:
Hanne L. P. Tytgat, Chia-wei Lin, Mikail D. Levasseur, Markus B. Tomek, Christoph Rutschmann, Jacqueline Mock, Nora Liebscher, Naohiro Terasaka, Yusuke Azuma, Michael Wetter, Martin F. Bachmann, Donald Hilvert, Markus Aebi, Timothy G. Keys
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Established bacterial glycoengineering platforms limit access to protein and glycan substrates. Here the authors design a cytoplasmic protein glycosylation system, Glycoli, to generate a variety of multivalent glycostructures.
Externí odkaz:
https://doaj.org/article/ac3f91e741e14ae68b947f045f6333f3
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
LIGHT is a member of the tumor necrosis factor superfamily, which has been claimed to mediate anti-tumor activity on the basis of cancer cures observed in immunocompetent mice bearing transgenic LIGHT-expressing tumors. The preclinical development of
Externí odkaz:
https://doaj.org/article/133106bc6a6c45fc9999fd8afd7fe8b4
Autor:
Sheila Dakhel, Christian Lizak, Mattia Matasci, Jacqueline Mock, Alessandra Villa, Dario Neri, Samuele Cazzamalli
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10020 (2021)
Antibody-cytokine fusion proteins (immunocytokines) are gaining importance for cancer therapy, but those products are often limited by systemic toxicity related to the activity of the cytokine payload in circulation and in secondary lymphoid organs.
Externí odkaz:
https://doaj.org/article/a6505dcd372f407391b9d37789feb336
Autor:
Andrea Galbiati, Aureliano Zana, Matilde Bocci, Jacopo Millul, Abdullah Elsayed, Jacqueline Mock, Dario Neri, Samuele Cazzamalli
Publikováno v:
J Nucl Med
Imaging procedures based on small-molecule radioconjugates targeting fibroblast activation protein (FAP) have recently emerged as a powerful tool for the diagnosis of a wide variety of tumors. However, the therapeutic potential of radiolabeled FAP-ta
Autor:
Hans-Jörg Breyholz, Samuele Cazzamalli, Andrea Galbiati, Wolfgang Roll, Paulina Marie Dorten, Michael Schäfers, Jacqueline Mock, Inga Asmus, Jacopo Millul, Florian Büther, Matthias Weckesser, Dario Neri, J. Tio, Klaus P. Schäfers, Philipp Backhaus, Stefan Wagner, Florian Gierse, Matthias C. Burg, Aureliano Zana, Sven Hermann, Juela Cufe
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging, 49 (6)
Purpose The fibroblast activation protein (FAP) is an emerging target for molecular imaging and therapy in cancer. OncoFAP is a novel small organic ligand for FAP with very high affinity. In this translational study, we establish [Ga-68]Ga-OncoFAP-DO
Autor:
Ilaria Spadafora, Marco Stringhini, Roman Spörri, Marco Catalano, Philipp Probst, Dario Neri, Jacqueline Mock
Publikováno v:
Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy, 70 (11)
Cancer Immunology, Immunotherapy, 70 (11)
There is a growing interest in the use of patient-derived T cells for the treatment of various types of malignancies. The expansion of a polyclonal and polyspecific population of tumor-reactive T cells, with a subsequent infusion into the same donor