Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Jacqueline M. Stephens"'
Autor:
Qianglin Liu, Chaoyang Li, Yuxia Li, Leshan Wang, Xujia Zhang, Buhao Deng, Peidong Gao, Mohammad Shiri, Fozi Alkaifi, Junxing Zhao, Jacqueline M. Stephens, Constantine A. Simintiras, Joseph Francis, Jiangwen Sun, Xing Fu
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102703- (2023)
Summary: Here, we present a protocol to isolate progenitor cells from mouse epididymal visceral adipose tissue and construct bulk RNA and assay for transposase-accessible chromatin with sequencing (ATAC-seq) libraries. We describe steps for adipose t
Externí odkaz:
https://doaj.org/article/43f997ca27a94005b434565c37580e47
Autor:
Qianglin Liu, Chaoyang Li, Buhao Deng, Peidong Gao, Leshan Wang, Yuxia Li, Mohammad Shiri, Fozi Alkaifi, Junxing Zhao, Jacqueline M. Stephens, Constantine A. Simintiras, Joseph Francis, Jiangwen Sun, Xing Fu
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112166- (2023)
Summary: Distinct locations of different white adipose depots suggest anatomy-specific developmental regulation, a relatively understudied concept. Here, we report a population of Tcf21 lineage cells (Tcf21 LCs) present exclusively in visceral adipos
Externí odkaz:
https://doaj.org/article/65e3fed5c9d44866822ef67295a31462
Publikováno v:
Biology, Vol 12, Iss 5, p 674 (2023)
Impaired adipocyte function contributes to systemic metabolic dysregulation, and altered fat mass or function increases the risk of Type 2 diabetes. EHMTs 1 and 2 (euchromatic histone lysine methyltransferases 1 and 2), also known as the G9a-like pro
Externí odkaz:
https://doaj.org/article/600e2673850640bf91c5b2ae6780dc5b
Autor:
Allison J. Richard, Hardy Hang, Timothy D. Allerton, Peng Zhao, Tamra Mendoza, Sujoy Ghosh, Carrie M. Elks, Jacqueline M. Stephens
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
STATs (Signal Transducers and Activators of Transcription) 5A and 5B are induced during adipocyte differentiation and are primarily activated by growth hormone (GH) and prolactin in fat cells. Previous studies in mice lacking adipocyte GH receptor or
Externí odkaz:
https://doaj.org/article/c611e1a1dffe4d1cb72c582aa31319d0
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
Botanicals have a long history of medicinal use for a multitude of ailments, and many modern pharmaceuticals were originally isolated from plants or derived from phytochemicals. Among these, artemisinin, first isolated from Artemisia annua, is the fo
Externí odkaz:
https://doaj.org/article/543cc2e91d084159afd33fe145e81888
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Adipocytes are the largest cell type in terms of volume, but not number, in adipose tissue. Adipocytes are prominent contributors to systemic metabolic health. Obesity, defined by excess adipose tissue (AT), is recognized as a low-grade chronic infla
Externí odkaz:
https://doaj.org/article/e1c16834496744f981ad14e114efee11
Publikováno v:
Open Biology, Vol 10, Iss 12 (2020)
Adipose, or fat, tissue (AT) was once considered an inert tissue that primarily existed to store lipids, and was not historically recognized as an important organ in the regulation and maintenance of health. With the rise of obesity and more rigorous
Externí odkaz:
https://doaj.org/article/d695ab5c5c4a404ea933b0f81208abae
Autor:
Anik Boudreau, Alexander Poulev, David M. Ribnicky, Ilya Raskin, Thirumurugan Rathinasabapathy, Allison J. Richard, Jacqueline M. Stephens
Publikováno v:
Frontiers in Nutrition, Vol 6 (2019)
Adipocytes are important players in metabolic health and disease, and disruption of adipocyte development or function contributes to metabolic dysregulation. Hence, adipocytes are significant targets for therapeutic intervention in obesity and metabo
Externí odkaz:
https://doaj.org/article/c3af25eb727249a2b116743a69561123
Autor:
Kelsey N. Olson, Dorien Reijnders, Viviane C. L. Gomes, R. Caitlin Hebert, Chin-Chi Liu, Jacqueline M. Stephens, Leanne M. Redman, Nataki C. Douglas, Jennifer L. Sones
Publikováno v:
Biology, Vol 9, Iss 9, p 304 (2020)
Preeclampsia (PE) is a serious hypertensive disorder of pregnancy characterized by abnormal placental development with an unknown etiology. To better understand which women will develop PE, a number of maternal risk factors have been identified, incl
Externí odkaz:
https://doaj.org/article/97c18f18fd35411ba155a63bb0f13b5a
Autor:
Carrie M. Elks, Jacqueline M. Stephens
Publikováno v:
Biology, Vol 4, Iss 1, Pp 151-160 (2015)
Oncostatin M (OSM) is a cytokine belonging to the gp130 family, whose members serve pleiotropic functions. However, several actions of OSM are unique from those of other gp130 cytokines, and these actions may have critical roles in inflammatory mecha
Externí odkaz:
https://doaj.org/article/4f10d547e4f74aa794280f99f6847621