Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Jacqueline M. Matthews"'
Autor:
Desmarini Desmarini, Daniel Truong, Lorna Wilkinson-White, Chandrika Desphande, Mario Torrado, Joel P. Mackay, Jacqueline M. Matthews, Tania C. Sorrell, Sophie Lev, Philip E. Thompson, Julianne Teresa Djordjevic
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1526 (2022)
New antifungals with unique modes of action are urgently needed to treat the increasing global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) pathway, comprised of IPKs that convert IP3 to IP8, provides a promisi
Externí odkaz:
https://doaj.org/article/fe7ab847de6948a7add6e26a15a3fb16
Autor:
Ngaio C. Smith, Lorna E. Wilkinson-White, Ann H.Y. Kwan, Jill Trewhella, Jacqueline M. Matthews
Publikováno v:
Journal of Structural Biology: X, Vol 5, Iss , Pp 100043- (2021)
The roles of ISL1 and LHX3 in the development of spinal motor neurons have been well established. Whereas LHX3 triggers differentiation into interneurons, the additional expression of ISL1 in developing neuronal cells is sufficient to redirect their
Externí odkaz:
https://doaj.org/article/c0ed827dc36b4429aef25aa70dff6885
Autor:
Mugdha Bhati, Estelle Llamosas, David A. Jacques, Cy M. Jeffries, Siavoush Dastmalchi, Nina Ripin, Hannah R. Nicholas, Jacqueline M. Matthews
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract LIM-Homeodomain (LIM-HD) transcription factors are highly conserved in animals where they are thought to act in a transcriptional ‘LIM code’ that specifies cell types, particularly in the central nervous system. In chick and mammals the
Externí odkaz:
https://doaj.org/article/d69119c3e92447f7a819a9bdea605bf6
Autor:
David B. Langley, Peter Schofield, Damien Nevoltris, Jennifer Jackson, Katherine J. L. Jackson, Tim J. Peters, Melanie Burk, Jacqueline M. Matthews, Antony Basten, Christopher C. Goodnow, Sheryl van Nunen, Joanne H. Reed, Daniel Christ
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Humans lack the capacity to produce the Galα1–3Galβ1–4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse set of immunogens, including commensal gut bacteria, malaria parasites, cetuximab, a
Publikováno v:
Current Opinion in Structural Biology. 66:156-162
Transcription factors are among the classes of proteins with the highest levels of disorder. Investigation of these regulatory proteins is uncovering not just the mechanisms that underlie gene regulation, but relationships that apply to all intrinsic
Publikováno v:
Chemical Society Reviews. 50:12292-12307
Protein interactions underlie most molecular events in biology. Many methods have been developed to identify protein partners, to measure the affinity with which these biomolecules interact and to characterise the structures of the complexes. Each ap
Autor:
Toby Passioura, Alex Norman, Louise J. Walport, Ana P. G. Silva, Jacqueline M. Matthews, Hiroaki Suga, Joel P. Mackay, Charlotte Franck, James L. Walshe, Kevork S Mouradian, Daniel H Tran, Richard J. Payne, Lorna Wilkinson-White, Paul D Solomon, Jason Low, K. Patel, J. Mitchell Guss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Large DNA-encoded libraries of cyclic peptides are emerging as powerful sources of molecules to tackle challenging drug targets. The structural and functional diversity contained within these libraries is, however, little explored. Here
Publikováno v:
Journal of Structural Biology: X, Vol 5, Iss, Pp 100043-(2021)
Journal of Structural Biology: X
Journal of Structural Biology: X
Graphical abstract
Highlights • The mechanisms by which ISL1 and LHX3 specify neuronal cell identity are unknown. • EMSA/SPR data show ISL1 and LHX3 have markedly different DNA-binding behaviours. • SAXS shows ISL1/LHX3:DNA complexes are f
Highlights • The mechanisms by which ISL1 and LHX3 specify neuronal cell identity are unknown. • EMSA/SPR data show ISL1 and LHX3 have markedly different DNA-binding behaviours. • SAXS shows ISL1/LHX3:DNA complexes are f
Autor:
Desmarini Desmarini, Jacqueline M. Matthews, Julianne T. Djordjevic, Ben Crossett, Tania C. Sorrell, Adolfo Saiardi, Lorna Wilkinson-White, Keren Kaufman-Francis, Sophie Lev, Cecilia Li, Dorothea Fiedler, David Furkert
Publikováno v:
mBio
mBio, Vol 11, Iss 5 (2020)
mBio, Vol 11, Iss 5 (2020)
Invasive fungal diseases pose a serious threat to human health globally with >1.5 million deaths occurring annually, 180,000 of which are attributable to the AIDS-related pathogen, Cryptococcus neoformans. Here, we demonstrate that interaction of the
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39218 (2012)
The proteins LMO4 and DEAF1 contribute to the proliferation of mammary epithelial cells. During breast cancer LMO4 is upregulated, affecting its interaction with other protein partners. This may set cells on a path to tumour formation. LMO4 and DEAF1
Externí odkaz:
https://doaj.org/article/811f90489a804e098a98e159490a72dd