Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jacqueline M. Dresch"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Transcription factor (TF) proteins are a key component of the gene regulatory networks that control cellular fates and function. TFs bind DNA regulatory elements in a sequence-specific manner and modulate target gene expression th
Externí odkaz:
https://doaj.org/article/dc8fa5fbf20f481ba63868f9132b2e85
Publikováno v:
PeerJ, Vol 11, p e15597 (2023)
The core promoter elements are important DNA sequences for the regulation of RNA polymerase II transcription in eukaryotic cells. Despite the broad evolutionary conservation of these elements, there is extensive variation in the nucleotide compositio
Externí odkaz:
https://doaj.org/article/1063db0e74c44bc6a7e1b095dcc73e20
Publikováno v:
PeerJ, Vol 3, p e1022 (2015)
It is well known that gene regulation is a tightly controlled process in early organismal development. However, the roles of key processes involved in this regulation, such as transcription and translation, are less well understood, and mathematical
Externí odkaz:
https://doaj.org/article/7672c41526a94312a2044204ea019f42
Autor:
Robert A Drewell, Tayla C Cormier, Jacob L Steenwyk, James St Denis, Javier F Tabima, Jacqueline M Dresch, Denis A Larochelle
Publikováno v:
NAR Genomics and Bioinformatics. 5
DNA methylation, the addition of a methyl (CH3) group to a cytosine residue, is an evolutionarily conserved epigenetic mark involved in a number of different biological functions in eukaryotes, including transcriptional regulation, chromatin structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e09b83949d9c6d0a02408921ea20ebc3
https://doi.org/10.1093/nargab/lqad035
https://doi.org/10.1093/nargab/lqad035
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185570 (2017)
Understanding the molecular machinery involved in transcriptional regulation is central to improving our knowledge of an organism's development, disease, and evolution. The building blocks of this complex molecular machinery are an organism's genomic
Externí odkaz:
https://doaj.org/article/e1e7b306d9444efaa4a66f2f8d0d6fbe
Publikováno v:
eLife, Vol 5 (2016)
Enhancers constitute one of the major components of regulatory machinery of metazoans. Although several genome-wide studies have focused on finding and locating enhancers in the genomes, the fundamental principles governing their internal architectur
Externí odkaz:
https://doaj.org/article/72f5df3e34a94926a1e811df1bf78999
Publikováno v:
Math Biosci
A detailed comprehension of transcriptional regulation is critical to understanding the genetic control of development and disease across many different organisms. To more fully investigate the complex molecular interactions controlling the precise e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0b2ee06eeb3741561cd187b6bfc445
https://doi.org/10.1016/j.mbs.2021.108716
https://doi.org/10.1016/j.mbs.2021.108716
Autor:
Donald E. Spratt, Robert A. Drewell, Jeanmarie Loss, Jacqueline M. Dresch, Rachel J. Orlomoski, Aaron Bogle, Rylee Simons
Publikováno v:
Protein Expr Purif
Homeodomain transcription factors (HD TFs) are a large class of evolutionarily conserved DNA binding proteins that contain a basic 60-amino acid region required for binding to specific DNA sites. In Drosophila melanogaster, many of these HD TFs are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417d90826ec8b538b49743be7f6f447d
https://pubmed.ncbi.nlm.nih.gov/30738927
https://pubmed.ncbi.nlm.nih.gov/30738927
Publikováno v:
Gene Regulation and Systems Biology, Vol 2016, Iss 10, Pp 21-33 (2016)
Gene Regulation and Systems Biology
Gene Regulation and Systems Biology
A long-standing objective in modern biology is to characterize the molecular components that drive the development of an organism. At the heart of eukaryotic development lies gene regulation. On the molecular level, much of the research in this field
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db550bd6fd634edbe5bcee898612b28
http://www.la-press.com/nucleotide-interdependency-in-transcription-factor-binding-sites-in-th-article-a5685
http://www.la-press.com/nucleotide-interdependency-in-transcription-factor-binding-sites-in-th-article-a5685
Autor:
Jacqueline M. Dresch, Lily Li, Michael J. Nevarez, Lauren N. Winkler, Jessica Kurata, Robert A. Drewell
Publikováno v:
Mechanisms of Development. 131:68-77
In Drosophila, the 330 kb bithorax complex regulates cellular differentiation along the anterior–posterior axis during development in the thorax and abdomen and is comprised of three homeotic genes: Ultrabithorax, abdominal-A, and Abdominal-B. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d174f1fb5692e939c0fb91a7e77210
https://doi.org/10.1016/j.mod.2013.10.002
https://doi.org/10.1016/j.mod.2013.10.002