Analysis of Copper-Induced Protein Precipitation across the E. coli Proteome

Autor: Amy T R Robison, Grace R Sturrock, Jacqueline M Zaengle-Barone, Nancy Wiebelhaus, Azim Dharani, Isabella G Williams, Michael C Fitzgerald, Katherine J Franz

Publikováno v: Metallomics : integrated biometal science.

Metal cations have been exploited for their precipitation properties in a wide variety of studies, ranging from differentiating proteins from serum and blood to identifying the protein targets of drugs. Despite widespread recognition of this phenomen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c8733a0b6febc903fe8f4b59f854b9
https://pubmed.ncbi.nlm.nih.gov/36549662

A Cephalosporin Prochelator Inhibits New Delhi Metallo-β-Lactamase 1 without Removing Zinc

Autor: Abigail C. Jackson, Elena A. Puccio, Katherine J. Franz, Jacqueline M. Zaengle-Barone

Publikováno v: ACS Infect Dis

Antibacterial drug resistance is a rapidly growing clinical threat, partially due to expression of β-lactamase enzymes, which confer resistance to bacteria by hydrolyzing and inactivating β-lactam antibiotics. The increasing prevalence of metallo-�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4220be6ceb342b307a957ba941493d8e
https://europepmc.org/articles/PMC7266096/

Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli

Autor: Amy T. R. Robison, Katherine J. Franz, Jesus Enrique Salcedo-Sora, Jacqueline M. Zaengle-Barone, Douglas B. Kell

Publikováno v: Molecules
Volume 26
Issue 19
Salcedo-Sora, J E, Robison, A T R, Zaengle-Barone, J, Franz, K J & Kell, D B 2021, ' Membrane transporters involved in the antimicrobial activities of pyrithione in escherichia coli ', Molecules, vol. 26, no. 19, 5826 . https://doi.org/10.3390/molecules26195826
Molecules, Vol 26, Iss 5826, p 5826 (2021)

Pyrithione (2-mercaptopyridine-N-oxide) is a metal binding modified pyridine, the antibacterial activity of which was described over 60 years ago. The formulation of zinc-pyrithione is commonly used in the topical treatment of certain dermatological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193ed0ed6bd8278783e88b0df9aab234
https://doi.org/10.3390/molecules26195826