Zobrazeno 1 - 10 of 41 pro vyhledávání: '"Jacqueline M Orian"'
1
Akademický článek
Computational characterization of 3' splice variants in the GFAP isoform family.
Autor: Sarah E Boyd, Betina Nair, Sze Woei Ng, Jonathan M Keith, Jacqueline M Orian
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33565 (2012)
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein specific to central nervous system (CNS) astrocytes. It has been the subject of intense interest due to its association with neurodegenerative diseases, and because of gr
Externí odkaz: https://doaj.org/article/cfc5401563e948259b508298673091b6
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2
Akademický článek
Cerebellar pathology in multiple sclerosis and experimental autoimmune encephalomyelitis: current status and future directions
Autor: Dain L. Maxwell, Jacqueline M. Orian
Publikováno v: Journal of Central Nervous System Disease, Vol 15 (2023)
Recent decades have witnessed significant progress in understanding mechanisms driving neurodegeneration and disease progression in multiple sclerosis (MS), but with a focus on the cerebrum. In contrast, there have been limited studies of cerebellar
Externí odkaz: https://doaj.org/article/683afd1a31bd48e9b5e66ac50237fb96
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3
Colorimetric histology using plasmonically active microscope slides
Autor: Eric Hanssen, G. Bruce Mann, Belinda S. Parker, Alex J. Spurling, Kate Harvey, Catherine Sadatnajafi, Belinda Yeo, Brian Abbey, Keith A. Nugent, Jacqueline M. Orian, Eugeniu Balaur, Sandra O’ Toole
Publikováno v: Nature. 598:65-71
The human eye can distinguish as many as 10,000 different colours but is far less sensitive to variations in intensity1, meaning that colour is highly desirable when interpreting images. However, most biological samples are essentially transparent, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09c5c6566d76612850788cc04e91b8ff
https://doi.org/10.1038/s41586-021-03835-2
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5
Immunomodulation Eliminates Inflammation in the Hippocampus in Experimental Autoimmune Encephalomyelitis, but Does Not Ameliorate Anxiety-Like Behavior
Autor: Jacqueline M. Orian, Nuzhat Tabassum-Sheikh, Pece Kocovski, Matthew W. Hale, Phuc T Dang, Stephanie Marinis
Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Multiple sclerosis (MS) is an autoimmune disease targeting the central nervous system, characterized by an unpredictable disease course and a wide range of symptoms. Emotional and cognitive deficits are now recognized as primary disease manifestation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59289679a5b33a66fed3e1f2113730e
http://europepmc.org/articles/PMC8222726
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6
Autoimmune encephalomyelitis in NOD mice is not initially a progressive multiple sclerosis model
Autor: Sandra Amor, Jacqueline M. Orian, Anne Cooke, Helen O'Shea, David Baker, Erik Nutma
Publikováno v: Annals of Clinical and Translational Neurology, 6(8), 1362-1372. John Wiley and Sons Ltd
Baker, D, Nutma, E, O'Shea, H, Cooke, A, Orian, J M & Amor, S 2019, ' Autoimmune encephalomyelitis in NOD mice is not initially a progressive multiple sclerosis model ', Annals of Clinical and Translational Neurology, vol. 6, no. 8, pp. 1362-1372 . https://doi.org/10.1002/acn3.792
Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1362-1372 (2019)
Annals of Clinical and Translational Neurology
Objective: Despite progress in treating relapsing multiple sclerosis (MS), effective inhibition of nonrelapsing progressive MS is an urgent, unmet, clinical need. Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE), provide v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2142aa3b3274f24df4cd2df86d8c015b
http://www.scopus.com/inward/record.url?scp=85070433939&partnerID=8YFLogxK
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7
Platelets in Multiple Sclerosis: Early and Central Mediators of Inflammation and Neurodegeneration and Attractive Targets for Molecular Imaging and Site-Directed Therapy
Autor: Jacqueline M. Orian, Claretta S. D'Souza, Pece Kocovski, Guy Krippner, Matthew W. Hale, Xiaowei Wang, Karlheinz Peter
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Platelets are clearly central to thrombosis and hemostasis. In addition, more recently, evidence has emerged for non-hemostatic roles of platelets including inflammatory and immune reactions/responses. Platelets express immunologically relevant ligan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80f6141338d41a03c336bd25e39827c
https://doi.org/10.3389/fimmu.2021.620963
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9
Platelets Drive Inflammation and Target Gray Matter and the Retina in Autoimmune-Mediated Encephalomyelitis
Autor: Dain Luke Maxwell, Sheila G. Crewther, Oliver Trusler, Claretta S D'Souza, Melanie J. Murphy, Zenjiang Li, Karlheinz Peter, Jacqueline M. Orian
Publikováno v: Journal of Neuropathology & Experimental Neurology. 77:567-576
Despite growing evidence for platelets as active players in infection and immunity, it remains unresolved whether platelets contribute to, or are key elements in the development of neuroinflammation. Using the experimental autoimmune encephalomyeliti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79389640835a695c9d0696597449eefe
https://doi.org/10.1093/jnen/nly032
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10
Platelet Depletion is Effective in Ameliorating Anxiety-Like Behavior and Reducing the Pro-Inflammatory Environment in the Hippocampus in Murine Experimental Autoimmune Encephalomyelitis
Autor: Claretta S D'Souza, Karlheinz Peter, Pece Kocovski, Weisan Chen, Matthew W. Hale, Phuc T Dang, Jacqueline M. Orian, Zhenjiang Li, Xiaowei Wang, Xiangrui Jiang
Publikováno v: Journal of Clinical Medicine, Vol 8, Iss 2, p 162 (2019)
Journal of Clinical Medicine
The neuropsychiatric symptoms of multiple sclerosis (MS), such as anxiety and depression, can result from disease activity itself as well as psychological reaction to an unfavorable diagnosis. Accordingly, the literature reports evidence of increased
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281615950d83790c5973037ea07974bf
https://www.mdpi.com/2077-0383/8/2/162
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