Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Jacqueline M, Matthews"'
Autor:
Desmarini Desmarini, Daniel Truong, Lorna Wilkinson-White, Chandrika Desphande, Mario Torrado, Joel P. Mackay, Jacqueline M. Matthews, Tania C. Sorrell, Sophie Lev, Philip E. Thompson, Julianne Teresa Djordjevic
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1526 (2022)
New antifungals with unique modes of action are urgently needed to treat the increasing global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) pathway, comprised of IPKs that convert IP3 to IP8, provides a promisi
Externí odkaz:
https://doaj.org/article/fe7ab847de6948a7add6e26a15a3fb16
Autor:
Ngaio C. Smith, Lorna E. Wilkinson-White, Ann H.Y. Kwan, Jill Trewhella, Jacqueline M. Matthews
Publikováno v:
Journal of Structural Biology: X, Vol 5, Iss , Pp 100043- (2021)
The roles of ISL1 and LHX3 in the development of spinal motor neurons have been well established. Whereas LHX3 triggers differentiation into interneurons, the additional expression of ISL1 in developing neuronal cells is sufficient to redirect their
Externí odkaz:
https://doaj.org/article/c0ed827dc36b4429aef25aa70dff6885
Autor:
Mugdha Bhati, Estelle Llamosas, David A. Jacques, Cy M. Jeffries, Siavoush Dastmalchi, Nina Ripin, Hannah R. Nicholas, Jacqueline M. Matthews
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract LIM-Homeodomain (LIM-HD) transcription factors are highly conserved in animals where they are thought to act in a transcriptional ‘LIM code’ that specifies cell types, particularly in the central nervous system. In chick and mammals the
Externí odkaz:
https://doaj.org/article/d69119c3e92447f7a819a9bdea605bf6
Autor:
Regula Hauswirth, Bianca Haase, Marlis Blatter, Samantha A Brooks, Dominik Burger, Cord Drögemüller, Vincent Gerber, Diana Henke, Jozef Janda, Rony Jude, K Gary Magdesian, Jacqueline M Matthews, Pierre-André Poncet, Vilhjálmur Svansson, Teruaki Tozaki, Lorna Wilkinson-White, M Cecilia T Penedo, Stefan Rieder, Tosso Leeb
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008321 (2019)
[This corrects the article DOI: 10.1371/journal.pgen.1002653.].
Externí odkaz:
https://doaj.org/article/f19b5b3acd674bac8112801fb4ac355b
Publikováno v:
Current Opinion in Structural Biology. 66:156-162
Transcription factors are among the classes of proteins with the highest levels of disorder. Investigation of these regulatory proteins is uncovering not just the mechanisms that underlie gene regulation, but relationships that apply to all intrinsic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eee3befd938bf578d8a05a24f1da48a
https://doi.org/10.1016/j.sbi.2020.10.026
https://doi.org/10.1016/j.sbi.2020.10.026
Autor:
David B. Langley, Peter Schofield, Damien Nevoltris, Jennifer Jackson, Katherine J. L. Jackson, Tim J. Peters, Melanie Burk, Jacqueline M. Matthews, Antony Basten, Christopher C. Goodnow, Sheryl van Nunen, Joanne H. Reed, Daniel Christ
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Humans lack the capacity to produce the Galα1–3Galβ1–4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse set of immunogens, including commensal gut bacteria, malaria parasites, cetuximab, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bea313d81cddc55d272059baba67db6
https://doi.org/10.1073/pnas.2123212119
https://doi.org/10.1073/pnas.2123212119
Publikováno v:
Chemical Society Reviews. 50:12292-12307
Protein interactions underlie most molecular events in biology. Many methods have been developed to identify protein partners, to measure the affinity with which these biomolecules interact and to characterise the structures of the complexes. Each ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc5af1a313fd50d4b61cf62e88c33d5
https://doi.org/10.1039/d1cs00548k
https://doi.org/10.1039/d1cs00548k
Autor:
Toby Passioura, Alex Norman, Louise J. Walport, Ana P. G. Silva, Jacqueline M. Matthews, Hiroaki Suga, Joel P. Mackay, Charlotte Franck, James L. Walshe, Kevork S Mouradian, Daniel H Tran, Richard J. Payne, Lorna Wilkinson-White, Paul D Solomon, Jason Low, K. Patel, J. Mitchell Guss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Large DNA-encoded libraries of cyclic peptides are emerging as powerful sources of molecules to tackle challenging drug targets. The structural and functional diversity contained within these libraries is, however, little explored. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52f097510d8784d0b302ac9b116d929
https://doi.org/10.1073/pnas.2003086117
https://doi.org/10.1073/pnas.2003086117
Autor:
Soumya Joseph, Ann H Kwan, Philippa H Stokes, Joel P Mackay, Liza Cubeddu, Jacqueline M Matthews
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109108 (2014)
LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind many partners, including the transcription factor Deformed epidermal autoregulatory factor-1
Externí odkaz:
https://doaj.org/article/093749faa0124e2ea08beea63a3356a5
Publikováno v:
Journal of Structural Biology: X, Vol 5, Iss, Pp 100043-(2021)
Journal of Structural Biology: X
Journal of Structural Biology: X
Graphical abstract
Highlights • The mechanisms by which ISL1 and LHX3 specify neuronal cell identity are unknown. • EMSA/SPR data show ISL1 and LHX3 have markedly different DNA-binding behaviours. • SAXS shows ISL1/LHX3:DNA complexes are f
Highlights • The mechanisms by which ISL1 and LHX3 specify neuronal cell identity are unknown. • EMSA/SPR data show ISL1 and LHX3 have markedly different DNA-binding behaviours. • SAXS shows ISL1/LHX3:DNA complexes are f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183accf50f29306523797799cd8f5d7b
http://www.sciencedirect.com/science/article/pii/S2590152420300295
http://www.sciencedirect.com/science/article/pii/S2590152420300295