Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jacqueline Leßig"'
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1316-1324 (2007)
The myeloperoxidase-derived metabolite hypochlorous acid (HOCl) promotes the selective cleavage of plasmalogens into chloro fatty aldehydes and 1-lysophosphatidylcholine (LPC). The subsequent conversion of the initially generated LPC was investigated
Externí odkaz:
https://doaj.org/article/9befeab6448f4d0f903b52f969316342
Publikováno v:
Journal of materials chemistry. B. 1(30)
The treatment of chronic inflammation requires new concepts since recent approaches are mostly accompanied by massive side effects. Layer-by-layer (LbL) microcapsules, functionalized with anti-inflammatory substances such as α1-antitrypsin (AT), may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb1e2af3fc8c1bdb1f42d78dfc9ec18
https://pubmed.ncbi.nlm.nih.gov/32261260
https://pubmed.ncbi.nlm.nih.gov/32261260
Publikováno v:
Macromolecular Bioscience. 15:546-557
Layer-by-Layer (LbL) coated microcarriers provide a multifunctional drug delivery system for therapeutic substances into specific cells. Inflammatory cells as polymorphonuclear leukocytes (PMNs) represent a particularly promising target for LbL-micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ea6391cce24185c438ae01287ec92ad
https://doi.org/10.1002/mabi.201400405
https://doi.org/10.1002/mabi.201400405
Autor:
Andreas Rosenwald, Stefan Gattenlöhner, Mathias J. Rummel, Torsten Hain, Alexander Burchardt, Andreas Bräuninger, Mehmet Kemal Tur, Michael Kiehl, Andreas Käbisch, Friedrich Grimminger, Marina Sorokina, Alexander Brobeil, Georg Schliesser, Kristin Kunze, Wolfgang Blau, Trinad Chakraborty, Ulrike Gamerdinger, Jacqueline Leßig-Owlanj
Publikováno v:
Pathology - Research and Practice. 210:369-376
Myelodysplastic syndromes (MDS) are hematopoietic disorders characterized by ineffective hematopoiesis and progression to acute leukemia. In patients ineligible for hematopoietic stem cell transplantation, azacitidine is the only treatment shown to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8860a577d1552c43d2603df6f8e7d4d3
https://doi.org/10.1016/j.prp.2014.02.006
https://doi.org/10.1016/j.prp.2014.02.006
Publikováno v:
Cytometry Part A. :461-471
α1 -Antitrypsin (AT), a serine protease inhibitor that specifically targets hydrolytic enzymes, plays a significant role in the termination of tissue inflammation and can therefore represent a key factor in chronic incidences as chronic obstructive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aab14b4aa94617433a486c4d2e631e1
https://doi.org/10.1002/cyto.a.22270
https://doi.org/10.1002/cyto.a.22270
Publikováno v:
Inflammation. 34:99-110
Drug delivery into immune cells has high potential for the treatment of all kinds of inflammation, allowing a target-oriented transport of active agents. The advantage of this local drug release is the prevention of negative effects of systemic appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a557c5d00afb57a594eab14b561f9677
https://doi.org/10.1007/s10753-010-9213-4
https://doi.org/10.1007/s10753-010-9213-4
Publikováno v:
International Journal of Andrology. 33:64-72
Elevated levels of polymorphonuclear leucocyte (PMN)-derived elastase, which is suggested as marker for inflammations in the male genital tract, correlate well with spermatozoa deterioration. PMN elastase caused a time- and concentration-dependent (u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef500ce4b17e73878aa37ef405daa4b8
https://doi.org/10.1111/j.1365-2605.2009.00954.x
https://doi.org/10.1111/j.1365-2605.2009.00954.x
Publikováno v:
Cellular Physiology and Biochemistry. 21:287-296
The heme-containing enzyme myeloperoxidase (MPO) becomes expressed to the cell surface of non-vital polymorphonuclear leukocytes (PMNs) as evidenced by flow cytometry analysis and confocal fluorescence microscopy. While only a very small percentage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0aa84de6fb897c3761027f857f117b
https://doi.org/10.1159/000129387
https://doi.org/10.1159/000129387
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1316-1324 (2007)
The myeloperoxidase-derived metabolite hypochlorous acid (HOCl) promotes the selective cleavage of plasmalogens into chloro fatty aldehydes and 1-lysophosphatidylcholine (LPC). The subsequent conversion of the initially generated LPC was investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eaeb221e5cec803aa97c43215b46223
https://doi.org/10.1194/jlr.m600478-jlr200
https://doi.org/10.1194/jlr.m600478-jlr200
Publikováno v:
Archives of Biochemistry and Biophysics. 459:137-142
Alpha1-antitrypsin is well known for its ability to inhibit human neutrophil elastase. Pretreatment of alpha1-antitrypsin with hypohalous acids HOCl and HOBr as well as with the myeloperoxidase-hydrogen peroxide-chloride (or bromide) system inactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8983b0f548a137ddac4281be1a3ecb7b
https://doi.org/10.1016/j.abb.2006.10.030
https://doi.org/10.1016/j.abb.2006.10.030