Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jacqueline L. S. Milne"'
Autor:
Erin E H Tran, Mario J Borgnia, Oleg Kuybeda, David M Schauder, Alberto Bartesaghi, Gabriel A Frank, Guillermo Sapiro, Jacqueline L S Milne, Sriram Subramaniam
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002797 (2012)
HIV-1 infection begins with the binding of trimeric viral envelope glycoproteins (Env) to CD4 and a co-receptor on target T-cells. Understanding how these ligands influence the structure of Env is of fundamental interest for HIV vaccine development.
Externí odkaz:
https://doaj.org/article/751ac1f8702e4987964ef6137c268483
Autor:
Tommi A White, Alberto Bartesaghi, Mario J Borgnia, Joel R Meyerson, M Jason V de la Cruz, Julian W Bess, Rachna Nandwani, James A Hoxie, Jeffrey D Lifson, Jacqueline L S Milne, Sriram Subramaniam
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001249 (2010)
The initial step in target cell infection by human, and the closely related simian immunodeficiency viruses (HIV and SIV, respectively) occurs with the binding of trimeric envelope glycoproteins (Env), composed of heterodimers of the viral transmembr
Externí odkaz:
https://doaj.org/article/d440939ed121407f8c78515c2771b2b5
Autor:
Alberto Bartesaghi, Jacqueline L. S. Milne, Sriram Subramaniam, Rajan Pragani, Veronica Falconieri, Lesley A. Earl, Prashant Rao, Alan Merk, Soojay Banerjee, Mindy I. Davis, Matthew B. Boxer
Publikováno v:
Cell. 165:1698-1707
Recent advances in single-particle cryoelecton microscopy (cryo-EM) are enabling generation of numerous near-atomic-resolution structures for well-ordered protein complexes with sizes ≥ ~200 kDa. Whether cryo-EM methods are equally useful for high-
Autor:
Xiongwu Wu, Jacqueline L. S. Milne, Soojay Banerjee, Sriram Subramaniam, Alan Merk, Alberto Bartesaghi, Doreen Matthies
Publikováno v:
Science. 348:1147-1151
Pushing the limits of electron microscopy Recent advances in cryo–electron microscopy (cryo-EM) allow structures of large macromolecules to be determined at near-atomic resolution. So far, though, resolutions approaching 2 Å, where features key to
Publikováno v:
Current opinion in structural biology. 46
The pace at which cryo-EM is being adopted as a mainstream tool in structural biology has continued unabated over the past year. Initial successes in obtaining near-atomic resolution structures with cryo-EM were enabled to a large extent by advances
Publikováno v:
Nature structural & molecular biology
The activation of trimeric HIV-1 envelope glycoprotein (Env) by its binding to the cell-surface receptor CD4 and co-receptors (CCR5 or CXCR4) represents the first of a series of events that lead to fusion between viral and target-cell membranes. Here
Autor:
Lesley A. Earl, Jacqueline L. S. Milne, Edward H. Egelman, Sriram Subramaniam, Veronica Falconieri
Publikováno v:
Current Opinion in Structural Biology
The prospect that the structures of protein assemblies, small and large, can be determined using cryo-electron microscopy (cryo-EM) is beginning to transform the landscape of structural biology and cell biology. Great progress is being made in determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30681099134ef31dd477e6d384ab96c8
https://europepmc.org/articles/PMC5154827/
https://europepmc.org/articles/PMC5154827/
Autor:
Michelle R. Arkin, Stacie L. Bulfer, Jacqueline L. S. Milne, Prashant Rao, Raymond J. Deshaies, Neal Jeffrey Green, Veronica Falconieri, Soojay Banerjee, Donna M. Huryn, Barbara Mroczkowski, Sriram Subramaniam, Alan Merk, Yongzhao Yan, Alberto Bartesaghi, Peter Wipf, R. Jeffrey Neitz
Publikováno v:
Science (New York, N.Y.), vol 351, iss 6275
p97 is a hexameric AAA+ adenosine triphosphatase (ATPase) that is an attractive target for cancer drug development. We report cryo-electron microscopy (cryo-EM) structures for adenosine diphosphate (ADP)-bound, full-length, hexameric wild-type p97 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa5b95e0d931c1f6fda01767caac345
https://resolver.caltech.edu/CaltechAUTHORS:20160208-092709831
https://resolver.caltech.edu/CaltechAUTHORS:20160208-092709831
Autor:
Sriram Subramaniam, Alan Merk, Prashant Rao, Lesley A. Earl, Mario J. Borgnia, Veronica Falconieri, Jacqueline L. S. Milne, Alberto Bartesaghi, Doreen Matthies, Soojay Banerjee, Jason Pierson
Publikováno v:
Molecular Pharmacology
Cryo-electron microscopy (cryo-EM) methods are now being used to determine structures at near-atomic resolution and have great promise in molecular pharmacology, especially in the context of mapping the binding of small-molecule ligands to protein co
Autor:
Haifeng He, Jacqueline L. S. Milne, Per Johan Klasse, Andre Marozsan, Yun Kenneth Kang, Mario J. Borgnia, Ian A. Wilson, Alberto Bartesaghi, William C. Olson, Rogier W. Sanders, Robert Pejchal, Rafael S. Depetris, Dan Shi, Sriram Subramaniam, Audray K. Harris, John P. Moore
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 108(28), 11440-11445. National Academy of Sciences
The initial step in HIV-1 infection occurs with the binding of cell surface CD4 to trimeric HIV-1 envelope glycoproteins (Env), a heterodimer of a transmembrane glycoprotein (gp41) and a surface glycoprotein (gp120). The design of soluble versions of