Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jacqueline L. Norris"'
Autor:
Zhao‐Wei Sun, Jarod M. Waybright, Serap Beldar, Lu Chen, Caroline A. Foley, Jacqueline L. Norris‐Drouin, Tian‐Jie Lyu, Aiping Dong, Jinrong Min, Yu‐Pu Wang, Lindsey I. James, Yun Wang
Publikováno v:
Advanced Science, Vol 10, Iss 25, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/d70ec315f7cd45e58fcaefeae7f5874e
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library
Autor:
Devan J. Shell, Justin M. Rectenwald, Peter H. Buttery, Rebecca L. Johnson, Caroline A. Foley, Shiva K.R. Guduru, Mélanie Uguen, Juanita Sanchez Rubiano, Xindi Zhang, Fengling Li, Jacqueline L. Norris-Drouin, Matthew Axtman, P. Brian Hardy, Masoud Vedadi, Stephen V. Frye, Lindsey I. James, Kenneth H. Pearce
Publikováno v:
SLAS Discovery, Vol 27, Iss 8, Pp 428-439 (2022)
Methyl-lysine (Kme) reader domains are prevalent in chromatin regulatory proteins which bind post-translational modification sites to recruit repressive and activating factors; therefore, these proteins play crucial roles in cellular signaling and ep
Externí odkaz:
https://doaj.org/article/859446a01131470eb8e3880dae7658e0
Autor:
Kelsey N. Lamb, Sarah N. Dishman, Jarod M. Waybright, Isabelle A. Engelberg, Justin M. Rectenwald, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Kenneth H. Pearce, Lindsey I. James, Stephen V. Frye
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 716-732 (2021)
Externí odkaz:
https://doaj.org/article/80ec6b26fa154dc6ae4b514e28795b9f
Autor:
Zhao‐Wei Sun, Jarod M. Waybright, Serap Beldar, Lu Chen, Caroline A. Foley, Jacqueline L. Norris‐Drouin, Tian‐Jie Lyu, Aiping Dong, Jinrong Min, Yu‐Pu Wang, Lindsey I. James, Yun Wang
Publikováno v:
Advanced Science, Vol 9, Iss 10, Pp n/a-n/a (2022)
Abstract Epigenetic modifications are involved in the onset, development, and maintenance of pain; however, the precise epigenetic mechanism underlying pain regulation remains elusive. Here it is reported that the epigenetic factor chromodomain Y‐l
Externí odkaz:
https://doaj.org/article/74310b4f2fb44ee3ab4ad07b520c84da
Autor:
Emily A. Hull-Ryde, John T. Minges, Mary E. B. Martino, Takafumi Kato, Jacqueline L. Norris-Drouin, Carla M. P. Ribeiro
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3063 (2021)
New anti-inflammatory treatments are needed for CF airway disease. Studies have implicated the endoplasmic reticulum stress transducer inositol requiring enzyme 1α (IRE1α) in CF airway inflammation. The activation of IRE1α promotes activation of i
Externí odkaz:
https://doaj.org/article/59841918a8584e6e93f5b58c54f752f4
Autor:
Justin M. Rectenwald, Shiva Krishna Reddy Guduru, Zhao Dang, Leonard B. Collins, Yi-En Liao, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Kyle W. Kaufmann, Scott M. Hammond, Dmitri B. Kireev, Stephen V. Frye, Kenneth H. Pearce
Publikováno v:
Molecules, Vol 25, Iss 4, p 979 (2020)
Chromatin structure and function, and consequently cellular phenotype, is regulated in part by a network of chromatin-modifying enzymes that place post-translational modifications (PTMs) on histone tails. These marks serve as recruitment sites for ot
Externí odkaz:
https://doaj.org/article/befc2b9a6ae44e7dbdde672ada128d9b
Autor:
Frances M. Bashore, Caroline A. Foley, Han Wee Ong, Justin M. Rectenwald, Ronan P. Hanley, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Christine A. Mills, Kenneth H. Pearce, Laura E. Herring, Dmitri Kireev, Stephen V. Frye, Lindsey I. James
Publikováno v:
ACS Chemical Biology. 18:494-507
Autor:
Mélanie Uguen, Yu Deng, Fengling Li, Devan J. Shell, Jacqueline L. Norris-Drouin, Michael A. Stashko, Suzanne Ackloo, Cheryl H. Arrowsmith, Lindsey I. James, Pengda Liu, Kenneth H. Pearce, Stephen V. Frye
Publikováno v:
bioRxiv
Increased expression and hyperactivation of the methyltransferase SETDB1 are commonly observed in cancer and central nervous system disorders. However, there are currently no reported SETDB1-specific methyltransferase inhibitors in the literature, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6935d47261a73543a1a18915cbf62a28
https://doi.org/10.1101/2023.05.10.539986
https://doi.org/10.1101/2023.05.10.539986
Autor:
Matthew C. Fleming, Lilly F. Chiou, Percy P. Tumbale, Gaith N. Droby, Jiwoong Lim, Jacqueline L. Norris-Drouin, Jason G. Williams, Kenneth H. Pearce, R. Scott Williams, Cyrus Vaziri, Albert A. Bowers
Publikováno v:
J Med Chem
MAGE proteins are well-known cancer testis antigens (CTAs) that are selectively expressed in cancer and germline cells. Characterized by the highly conserved MAGE homology domain (MHD), MAGEs are increasingly reported to play pivotal roles in promoti
Autor:
Neal R Rasmussen, Zufan Debebe, Tricia M Wright, Samira A Brooks, Adam B Sendor, A Rose Brannon, A Ari Hakimi, James J Hsieh, Toni K Choueiri, Pheroze Tamboli, Jodi K Maranchie, Peter Hinds, Eric M Wallen, Catherine Simpson, Jacqueline L Norris, William P Janzen, W Kimryn Rathmell
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116101 (2014)
Ror2 is a Wnt ligand receptor that is overexpressed in a variety of tumors including clear cell renal cell carcinoma (ccRCC). Here we demonstrate that expression of wild type Ror2 results in increased tumorigenic properties in in vitro cell culture a
Externí odkaz:
https://doaj.org/article/d4d244773c3a4a8d89851013994ac4a2