Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jacqueline K. Dulworth"'
Publikováno v:
The Journal of pharmacy and pharmacology. 51(11)
The purpose of this work was to determine any effects the presence of sodium carboxymethyl starch may have on the antimicrobial activity of vancomycin given a previously described interaction between vancomycin and sodium carboxymethyl starch. In par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6acf8503e697691b46f6ff8940d87a8c
https://pubmed.ncbi.nlm.nih.gov/10632093
https://pubmed.ncbi.nlm.nih.gov/10632093
Publikováno v:
Chemotherapy. 43(4)
Compound MDL 62,879 (GE2270 A) is a thiazolyl peptide antibiotic that appears to inhibit aminoacyl-tRNA binding to elongation factor Tu. In the present study, it was shown that MDL 62,879 broth microdilution MIC values were generally 2-4 doubling dil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0547e442fc166d72d221dcafc0fce9
https://pubmed.ncbi.nlm.nih.gov/9209782
https://pubmed.ncbi.nlm.nih.gov/9209782
Autor:
Jacquelyn A. Smithers, Henrik K. Kulmala, Stephen J. Ruberg, Charles E. Halstenson, Michael T. Kenny, Jacqueline K. Dulworth, Bruce E. Shapiro, Eric W. Lewis, William F. Keane, Gary A. Thompson
Publikováno v:
Biopharmaceuticsdrug disposition. 13(8)
The pharmacokinetics of teicoplanin were investigated in 13 subjects with various degrees of renal impairment using a randomized two-period crossover design; 11 subjects completed both periods. Doses of 3 and 30 mg kg-1 were administered as single do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03a91b87f5d5b1c85ecd09da139e54d
https://pubmed.ncbi.nlm.nih.gov/1421051
https://pubmed.ncbi.nlm.nih.gov/1421051
Autor:
Jacqueline K. Dulworth, Kelly K. Antony, Marcia B. Brackman, Gary A. Thompson, Lianng Yuh, Mark G. Eller, Ron Kuzma, Michael T. Kenny, Eric W. Lewis
Publikováno v:
Journal of pharmaceutical sciences. 80(6)
Pharmacokinetics, bioavailability, and local tolerance (at the site of intramuscular administration) of a new formulation of teicoplanin (400 mg/3 mL) were investigated in 24 normal, healthy, male volunteers. A single dose of 6 mg/kg was administered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00eba5f74c536e5440f57663535fe432
https://pubmed.ncbi.nlm.nih.gov/1834827
https://pubmed.ncbi.nlm.nih.gov/1834827
Publikováno v:
Diagnostic microbiology and infectious disease. 14(1)
In this study, the in vitro activity of teicoplanin and vancomycin was directly compared against 503 Gram-positive cocci isolated during the U.S. teicoplanin clinical trials. Both antibiotics were equally active against oxacillin-sensitive Staphyloco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feed6fca29f68219b4ceac1139105da5
https://pubmed.ncbi.nlm.nih.gov/1826479
https://pubmed.ncbi.nlm.nih.gov/1826479
Autor:
Steven L. Roberds, Michael T. Kenny, Michael C. Graham, Harry L. Torney, Wen-Dar Cheng, Jacqueline K. Dulworth
Publikováno v:
International Journal of Immunopharmacology. 10:639-649
At physiologically relevant concentrations an antiviral compound should not perturb the host's ability to mount an immune response against the infecting virus or some other opportunistic pathogen. The purpose of this study was to evaluate the immunom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f79a61bb7bbc5679c2ee71f8040cd37
https://doi.org/10.1016/0192-0561(88)90017-3
https://doi.org/10.1016/0192-0561(88)90017-3
Publikováno v:
Antiviral research. 6(6)
Fifteen p-benzoylphenoxypyridines were initially evaluated for their in vitro activity against rhinoviruses (RV) 1A, 2 and 64 and coxsackie virus (Cox) A21 and for their oral prophylactic and therapeutic activity in Swiss albino mice lethally challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f46f64ebafabd4f53d7876c06d1897
https://pubmed.ncbi.nlm.nih.gov/3777916
https://pubmed.ncbi.nlm.nih.gov/3777916
Publikováno v:
Antiviral Research
The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound's effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5620aeb785744793631fd966be93535a
https://pubmed.ncbi.nlm.nih.gov/2849377
https://pubmed.ncbi.nlm.nih.gov/2849377
Autor:
Lowell D. Markley, Christopher T. Goralski, Wood Steven Glen, Anna P. Vinogradoff, David L. Steward, Howard Johnston, Yulan C. Tong, Jacqueline K. Dulworth, Thomas M. Bargar
Publikováno v:
Journal of medicinal chemistry. 29(3)
Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1d791cff70847579b65b75036843fa
https://pubmed.ncbi.nlm.nih.gov/3005578
https://pubmed.ncbi.nlm.nih.gov/3005578
Autor:
Jacqueline K. Dulworth, Renee Massad, John K. Daniel, Michael T. Kenny, Roger N. Sargent, T. M. Bargar, Thomas Michael Wilson
Publikováno v:
Journal of medicinal chemistry. 29(9)
A general synthesis to the title compounds 1, substituted in the 6-position and on the phenyl ring, is outlined. Eighteen analogues were compared with respect to in vitro activity against rhinovirus types 1A, 9, and 64. Compounds 1c and 1h, the 6-bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25224187dbfd1cd5d1079f838fff33f0
https://pubmed.ncbi.nlm.nih.gov/3018241
https://pubmed.ncbi.nlm.nih.gov/3018241