Myeloid cells promote interferon signaling-associated deterioration of the hematopoietic system

Autor: Jacqueline Feyen, Zhen Ping, Lanpeng Chen, Claire van Dijk, Tim V. D. van Tienhoven, Paulina M. H. van Strien, Remco M. Hoogenboezem, Michiel J. W. Wevers, Mathijs A. Sanders, Ivo P. Touw, Marc H. G. P. Raaijmakers

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Innate and adaptive immune cells function in the homeostasis of haematopoietic stem cells (HSC). Here the authors show that myeloid cells are able to reduce the function of HSCs via interferon signaling through a neutrophil-NK cell dependent process.

Externí odkaz: https://doaj.org/article/9f3d9e52bb044dac844af641eab95cd4

A congenital CSF3R mutation in chronic neutropenia reveals a vital role for a cytokine receptor extracellular hinge motif in the response to granulocyte colony‐stimulating factor

Autor: Jacqueline Feyen, Martijn P. T. Ernst, Vincent H. J. van der Velden, Peter J. M. Valk, Lianne Broeders, Ivo P. Touw, Marc H. G. P. Raaijmakers

Publikováno v: Pediatric Blood and Cancer, 70(4):e30039. Wiley-Liss Inc.

We describe a patient with congenital neutropenia (CN) with a homozygous germline mutation in the colony-stimulating factor 3 receptor gene (CSF3R). The patient's bone marrow shows lagging neutrophil development with subtle left shift and unresponsiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eae77d1cd4366ed2f9e6955f9aa1fd9
https://doi.org/10.1002/pbc.30039

Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Autor: Si Chen, D.J. Lindenbergh-Kortleve, Keane Jared Guillaume Kenswil, Mathijs A. Sanders, Sjoerd J. F. Hermans, Janneke N. Samsom, Athina Mylona, Zhen Ping, Eline M. P. Cremers, Niken M. Adisty, Remco Hoogenboezem, Arjan A. van de Loosdrecht, Marc H.G.P. Raaijmakers, Eric Bindels, Claire van Dijk, Jacqueline Feyen

Publikováno v: Leukemia, 33(2), 536-541. Nature Publishing Group
Leukemia
Ping, Z, Chen, S, Hermans, S J F, Kenswil, K J G, Feyen, J, van Dijk, C, Bindels, E M J, Mylona, A M, Adisty, N M, Hoogenboezem, R M, Sanders, M A, Cremers, E M P, Lindenbergh-Kortleve, D J, Samsom, J N, van de Loosdrecht, A A & Raaijmakers, M H G P 2019, ' Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes ', Leukemia, vol. 33, no. 2, pp. 536-541 . https://doi.org/10.1038/s41375-018-0267-x

Highlights Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.Activation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e271efe8d622fa3dcfda8407cf025d
https://research.vumc.nl/en/publications/83e7724d-b8a6-4a9f-a0e4-a914355f6659