Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Jacqueline F. McGinty"'
Autor:
Kelsey M. Vollmer, Lisa M. Green, Roger I. Grant, Kion T. Winston, Elizabeth M. Doncheck, Christopher W. Bowen, Jacqueline E. Paniccia, Rachel E. Clarke, Annika Tiller, Preston N. Siegler, Bogdan Bordieanu, Benjamin M. Siemsen, Adam R. Denton, Annaka M. Westphal, Thomas C. Jhou, Jennifer A. Rinker, Jacqueline F. McGinty, Michael D. Scofield, James M. Otis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract Suppression of dangerous or inappropriate reward-motivated behaviors is critical for survival, whereas therapeutic or recreational opioid use can unleash detrimental behavioral actions and addiction. Nevertheless, the neuronal systems that s
Externí odkaz:
https://doaj.org/article/f0bc29247a204771859cdb2512d2b3cb
Autor:
Kelsey M. Vollmer, Lisa M. Green, Roger I. Grant, Kion T. Winston, Elizabeth M. Doncheck, Christopher W. Bowen, Jacqueline E. Paniccia, Rachel E. Clarke, Annika Tiller, Preston N. Siegler, Bogdan Bordieanu, Benjamin M. Siemsen, Adam R. Denton, Annaka M. Westphal, Thomas C. Jhou, Jennifer A. Rinker, Jacqueline F. McGinty, Michael D. Scofield, James M. Otis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a10243d94f984facbf4098b64656b615
Autor:
Benjamin M. Siemsen, Adam R. Denton, Jeffrey Parrila-Carrero, Kaylee N. Hooker, Eilish A. Carpenter, Meagan E. Prescot, Ashley G. Brock, Annaka M. Westphal, Mary-Nan Leath, John A. McFaddin, Thomas C. Jhou, Jacqueline F. McGinty, Michael D. Scofield
Publikováno v:
Cells, Vol 12, Iss 14, p 1812 (2023)
Clinical and preclinical studies indicate that adaptations in corticostriatal neurotransmission significantly contribute to heroin relapse vulnerability. In animal models, heroin self-administration and extinction produce cellular adaptations in both
Externí odkaz:
https://doaj.org/article/cea775f7c6d34c87a6eabb9adff3d4c6
Autor:
Jacqueline F. McGinty
Publikováno v:
Addiction Neuroscience, Vol 2, Iss , Pp 100006- (2022)
Cocaine self-administration disturbs intracellular signaling in multiple reward circuitry neurons that underlie relapse to drug seeking. Cocaine-induced deficits in prelimbic (PL) prefrontal cortex change during abstinence, resulting in different neu
Externí odkaz:
https://doaj.org/article/7d44669f1bcf41618aa9ecda903ca04b
Autor:
Jacqueline F. McGinty, James M. Otis
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2020)
The paraventricular thalamic nucleus (PVT) is highly interconnected with brain areas that control reward-seeking behavior. Despite this known connectivity, broad manipulations of PVT often lead to mixed, and even opposing, behavioral effects, cloudin
Externí odkaz:
https://doaj.org/article/213dc20678b64fddba28339b51a1551a
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 459-466 (2009)
Inflammation, phospho-p38 MAPK activation, and a reduction in glial cell line-derived neurotrophic factor (GDNF) occur in Parkinson's disease. Microglial activation in the substantia nigra and a tyrosine hydroxylase deficit in the striatum of 3-month
Externí odkaz:
https://doaj.org/article/d3aa23ba4d354007987ac373d3b59a20
Autor:
Saurabh S. Kokane, Robert D. Cole, Bogdan Bordieanu, Chevin M. Ray, Ishraq A. Haque, James M. Otis, Jacqueline F. McGinty
Publikováno v:
The Journal of Neuroscience. 43:4019-4032
Dysregulation of the input from the prefrontal cortex (PFC) to the nucleus accumbens (NAc) contributes to cue-induced opioid seeking but the heterogeneity in, and regulation of, prelimbic (PL)-PFC to NAc (PL->NAc) neurons that are altered has not bee
Autor:
Scofield, Benjamin M. Siemsen, Adam R. Denton, Jeffrey Parrila-Carrero, Kaylee N. Hooker, Eilish A. Carpenter, Meagan E. Prescot, Ashley G. Brock, Annaka M. Westphal, Mary-Nan Leath, John A. McFaddin, Thomas C. Jhou, Jacqueline F. McGinty, Michael D.
Publikováno v:
Cells; Volume 12; Issue 14; Pages: 1812
Clinical and preclinical studies indicate that adaptations in corticostriatal neurotransmission significantly contribute to heroin relapse vulnerability. In animal models, heroin self-administration and extinction produce cellular adaptations in both
Autor:
Rechelle Paranal, Joseph Gough, Heather Shaw Bonilha, Edward L. Krug, Jacqueline F. McGinty, Kathleen T. Brady, Jillian Harvey, Kathie L. Hermayer, Marc I. Chimowitz, Madison Hyer, Gerard A. Silvestri, Perry V. Halushka, Bonnie Martin-Harris, Joann F. Sullivan, Barbara J Edlund, Mary Mauldin, Dayan Ranwala
Publikováno v:
Journal of Clinical and Translational Science
Background:There is discontent and turnover among faculty at US academic health centers because of the challenges in balancing clinical, research, teaching, and work–life responsibilities in the current healthcare environment. One potential strateg
Publikováno v:
Addiction Biology. 23:1233-1241
Recreational drug use peaks during adolescence. Our research with adolescent vs adult male rats, however, shows that rats taking cocaine as adolescents have lower levels of cue-induced reinstatement of drug-seeking than adults, despite similar levels