Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jacqueline E. Shea"'
Autor:
Pablo Tebas, ShuPing Yang, Jean D. Boyer, Emma L. Reuschel, Ami Patel, Aaron Christensen-Quick, Viviane M. Andrade, Matthew P. Morrow, Kimberly Kraynyak, Joseph Agnes, Mansi Purwar, Albert Sylvester, Jan Pawlicki, Elisabeth Gillespie, Igor Maricic, Faraz I. Zaidi, Kevin Y. Kim, Yaya Dia, Drew Frase, Patrick Pezzoli, Katherine Schultheis, Trevor R.F. Smith, Stephanie J. Ramos, Trevor McMullan, Karen Buttigieg, Miles W. Carroll, John Ervin, Malissa C. Diehl, Elliott Blackwood, Mammen P. Mammen, Jessica Lee, Michael J. Dallas, Ami Shah Brown, Jacqueline E. Shea, J.Joseph Kim, David B. Weiner, Kate E. Broderick, Laurent M. Humeau
Publikováno v:
EClinicalMedicine, Vol 31, Iss , Pp 100689- (2021)
Background: A vaccine against SARS-CoV-2 is of high urgency. Here the safety and immunogenicity induced by a DNA vaccine (INO-4800) targeting the full length spike antigen of SARS-CoV-2 are described. Methods: INO-4800 was evaluated in two groups of
Externí odkaz:
https://doaj.org/article/a9f1cb97a12243469984e15dede48ebe
Autor:
Mammen P. Mammen, Pablo Tebas, Joseph Agnes, Mary Giffear, Kimberly A. Kraynyak, Elliott Blackwood, Dinah Amante, Emma L. Reuschel, Mansi Purwar, Aaron Christensen-Quick, Nieman Liu, Viviane M. Andrade, Julie Carter, Gabriella Garufi, Malissa C. Diehl, Albert Sylvester, Matthew P. Morrow, Patrick Pezzoli, Abhijeet J. Kulkarni, Faraz I. Zaidi, Drew Frase, Kevin Liaw, Hedieh Badie, Keiko O. Simon, Trevor R.F. Smith, Stephanie Ramos, Robert Spitz, Robert J. Juba, Jessica Lee, Michael Dallas, Ami Shah Brown, Jacqueline E. Shea, J. Joseph Kim, David B. Weiner, Kate E. Broderick, Jean D. Boyer, Laurent M. Humeau
BackgroundVaccines against SARS-CoV-2 are still urgently needed as only 5% of the global population has been vaccinated. Here we report the safety and immunogenicity of a DNA vaccine (INO-4800) targeting the full-length Spike antigen of SARS-CoV-2 wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65bb33f42e855f7d0b873b47add357f8
https://doi.org/10.1101/2021.05.07.21256652
https://doi.org/10.1101/2021.05.07.21256652
Autor:
Karen R. Buttigieg, Emma L. Reuschel, Trevor R.F. Smith, Jean D. Boyer, Malissa Diehl, Elisabeth Gillespie, Laurent Humeau, Stephanie Ramos, Mammen P Mammen, J. Joseph Kim, John Ervin, Yaya Dia, Miles W. Carroll, Aaron Christensen-Quick, Kate E. Broderick, Katherine Schultheis, Jan Pawlicki, Jacqueline E. Shea, Igor Maricic, Michael J. Dallas, Shu Ping Yang, Elliott Blackwood, Drew Frase, Kimberly A. Kraynyak, Mansi Purwar, Ami Shah Brown, Jessica Lee, Faraz I. Zaidi, Kevin Kim, Trevor McMullan, David B. Weiner, Joseph Agnes, Viviane M Andrade, Matthew P. Morrow, Patrick Pezzoli, Ami Patel, Albert Sylvester, Pablo Tebas
Publikováno v:
EClinicalMedicine, Vol 31, Iss, Pp 100689-(2021)
EClinicalMedicine
EClinicalMedicine
Background A vaccine against SARS-CoV-2 is of high urgency. Here the safety and immunogenicity induced by a DNA vaccine (INO-4800) targeting the full length spike antigen of SARS-CoV-2 are described. Methods INO-4800 was evaluated in two groups of 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e0dba1f802d8ec60ef4c7d91c933a7
http://www.sciencedirect.com/science/article/pii/S2589537020304338
http://www.sciencedirect.com/science/article/pii/S2589537020304338
Publikováno v:
Current Opinion in Microbiology. 3:451-458
Signature-tagged mutagenesis is a functional genomics technique that identifies microbial genes required for infection within an animal host, or within host cells. The application of this technique to a range of microbial pathogens has resulted in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8b929e664c4e491e748e882925a6e4
https://doi.org/10.1016/s1369-5274(00)00120-x
https://doi.org/10.1016/s1369-5274(00)00120-x
Publikováno v:
Infection and Immunity. 67:213-219
We have investigated the in vivo growth kinetics of a Salmonella typhimurium strain (P11D10) carrying a mutation in ssaJ , a Salmonella pathogenicity island 2 (SPI2) gene encoding a component of a type III secretion system required for systemic growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed77316efcec1394f11e159e66d01438
https://doi.org/10.1128/iai.67.1.213-219.1999
https://doi.org/10.1128/iai.67.1.213-219.1999
Autor:
Jacqueline E. Shea, Thomas Nikolaus, Colin Gleeson, Michael Hensel, Rosanna Mundy, Scott R. Waterman, David W. Holden, Andrés Vázquez-Torres, Geoff Banks, Ferric C. Fang
Publikováno v:
Molecular Microbiology. 30:163-174
Summary The type III secretion system of Salmonella pathogenicity island 2 (SPI-2) is required for systemic infection of this pathogen in mice. Cloning and sequencing of a central region of SPI-2 revealed the presence of genes encoding putative chape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d792fa29059a72d4b6eea8ff60cde16c
https://doi.org/10.1046/j.1365-2958.1998.01047.x
https://doi.org/10.1046/j.1365-2958.1998.01047.x
Publikováno v:
Molecular Microbiology. 29:1019-1027
Fungal ribotoxins, such as mitogillin and the related Aspergillus toxins restrictocin and alpha-sarcin, are highly specific ribonucleases, which inactivate the ribosome enzymatically by cleaving the eukaryotic 28S RNA of the large ribosomal subunit a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e175bd10a9dd82ea8eae99076580cbcb
https://doi.org/10.1046/j.1365-2958.1998.00987.x
https://doi.org/10.1046/j.1365-2958.1998.00987.x
Autor:
Michael Hensel, Toru Kubo, Denise M. Monack, Stanley Falkow, Colin Gleeson, David William Holden, Jacqueline E. Shea, Barbel Raupach
Publikováno v:
Molecular Microbiology. 24:155-167
Summary We have investigated the structure and transcriptional organization of 13 genes of Salmonella Pathogenicity Island 2 (SPI2) that encode components of the second type III secretion apparatus of Salmonella typhimurium. ssaK, L, M, V, N, O, P, Q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c629b2c4f313c8e348278f7ca08f15
https://doi.org/10.1046/j.1365-2958.1997.3271699.x
https://doi.org/10.1046/j.1365-2958.1997.3271699.x
Autor:
Emma Dalton, Jacqueline E. Shea, Michael D. Jones, Michael Hensel, David W. Holden, Colin Gleeson
Publikováno v:
Science. 269:400-403
An insertional mutagenesis system that uses transposons carrying unique DNA sequence tags was developed for the isolation of bacterial virulence genes. The tags from a mixed population of bacterial mutants representing the inoculum and bacteria recov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ad624bc37ed38f61192f713a5ab2c1
https://doi.org/10.1126/science.7618105
https://doi.org/10.1126/science.7618105
Publikováno v:
Nucleic Acids Research. 22:5555-5564
The dbf3 mutation was originally obtained in a screen for DNA synthesis mutants with a cell cycle phenotype in the budding yeast Saccharomyces cerevisiae. We have now isolated the DBF3 gene and found it to be an essential gene with an ORF of 7239 nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83819e5cb6ad1b05c70596e960ed760f
https://doi.org/10.1093/nar/22.25.5555
https://doi.org/10.1093/nar/22.25.5555