Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jacqueline E. Calvano"'
Autor:
Jacqueline E. Calvano, Stephen F. Lowry, Susette M. Coyle, Michael T. Reddell, Daniel J. Bowers, Marie A. Macor, Steve E. Calvano, Ashwini Kumar
Publikováno v:
Clinical Immunology. 121:186-190
Mutations (Asp299Gly and Thr399Ile) in the human Toll-like receptor 4 (hTLR4) gene are reportedly associated with hyporesponsiveness to inhaled LPS in humans. It was hypothesized that normal volunteers with these hTLR4 mutations would manifest altere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6bb09e27b3dc1ca9b816b7efbf8309
https://doi.org/10.1016/j.clim.2006.05.012
https://doi.org/10.1016/j.clim.2006.05.012
Autor:
John Y. Um, Doreen M. Agnese, Jacqueline E. Calvano, Ashwini Kumar, Susette M. Coyle, Stephen F. Lowry, Steve E. Calvano, Sae J. Hahm
Publikováno v:
Surgical Infections. 4:163-169
Tumor necrosis factor-alpha (TNF-alpha) is a well-documented central inflammatory mediator in sepsis. Specific polymorphisms of the TNF-alpha and TNF-beta genes (TNF2 and LTA + 250, respectively) have been suggested to correlate with higher mortality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecaafb97eafffd2345252bb5e7cbd317
https://doi.org/10.1089/109629603766956951
https://doi.org/10.1089/109629603766956951
Autor:
Susette M. Coyle, Marie A. Macor, Ashwini Kumar, Beatrice Haimovich, Siobhan A. Corbett, Zhiyong Zhang, Steve E. Calvano, Stephen F. Lowry, Jacqueline E. Calvano
Objective The Toll-like receptor 4 (TLR4) ligand endotoxin triggers robust systemic inflammatory responses in humans at doses equal to or greater than 1 ng/kg. In this study, we tested the hypothesis that evidence of TLR4-induced responses would be d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95183a2c84fa97214666fb18289e3c0
https://europepmc.org/articles/PMC4362694/
https://europepmc.org/articles/PMC4362694/
Publikováno v:
Breast Cancer Research and Treatment. 69:115-122
The E2F family of transcription factors can induce both cell proliferation and apoptosis. Whether they function as oncogenes or tumor suppressors appears to be tissue specific. Their role in breast carcinogenesis remains unclear. We found a decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b217b0e2befbbff9822eb7ad018067aa
https://doi.org/10.1023/a:1012230115173
https://doi.org/10.1023/a:1012230115173
Autor:
Maria Bisogna, Jacqueline E. Calvano, Gay Hui Ho, Irene Orlow, Carlos Cordón-Cardó, Patrick I. Borgen, Kimberly J. Van Zee
Publikováno v:
Cancer Genetics and Cytogenetics. 125:131-138
The INK4A and INK4B loci are located at 9p21 and have been implicated in the tumorigenesis of various human malignancies. The INK4A gene encodes two cell cycle regulators, p16(INK4A) and ARF, while INK4B encodes p15(INK4B). Previously, we have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb7429e630a0d5eb03b45eff7965dbe
https://doi.org/10.1016/s0165-4608(00)00367-8
https://doi.org/10.1016/s0165-4608(00)00367-8
Autor:
Gay Hui Ho, Jacqueline E. Calvano, Maria Bisogna, Ziad Abouezzi, Patrick I. Borgen, Carlos Cordón-Cardó, Kimberly J. Van Zee
Publikováno v:
Breast Cancer Research and Treatment. 65:225-232
TP53 is the most commonly mutated tumor suppressor gene in human cancers. The amplification and overexpression of HDM2 plays a role in tumorigenesis via inactivation of p53-dependent cell cycle arrest. p14ARF, an alternate transcript of the INK4A tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b886118cbb88e794fb8cc25ca36733
https://doi.org/10.1023/a:1010686518990
https://doi.org/10.1023/a:1010686518990
Autor:
Gay Hui Ho, Jacqueline E. Calvano, Maria Bisogna, Patrick I. Borgen, Paul P. Rosen, Lee K. Tan, Kimberly J. Van Zee
Publikováno v:
Cancer. 89:2153-2160
BACKGROUND HER-2/neu and p53 are two molecular markers that have been the focus of investigation in patients with invasive breast carcinoma. However, most of the published data have relied on immunohistochemical detection of the proteins as a surroga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1dba667bbb0b2c3bf2c8f8fac8a99ab
https://doi.org/10.1002/1097-0142(20001201)89:11<2153::aid-cncr2>3.0.co
https://doi.org/10.1002/1097-0142(20001201)89:11<2153::aid-cncr2>3.0.co
Publikováno v:
Annals of Surgical Oncology. 4:310-315
Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eef9b1c5d66b0edaa77c7d29b1fc4df
https://doi.org/10.1007/bf02303580
https://doi.org/10.1007/bf02303580
Autor:
Adrian D. Haimovich, Beatrice Haimovich, Jacqueline E. Calvano, Stephen F. Lowry, Susette M. Coyle, Steve E. Calvano
The intravenous administration of a bolus dose of endotoxin to healthy human subjects triggers acute systemic inflammatory responses that include cytokine production and dynamic changes in gene expression in peripheral blood leukocytes. This study so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f33726b2674a4e34ee3314a4e3b10a
https://europepmc.org/articles/PMC2929957/
https://europepmc.org/articles/PMC2929957/
Autor:
Marie A. Macor, Steve E. Calvano, David A. Kleiman, Susette M. Coyle, Jacqueline E. Calvano, Stephen F. Lowry
Publikováno v:
American journal of surgery. 197(1)
Background The Mdm2 -SNP309(T/G) polymorphism has been shown to upregulate transcription of Mdm2 and subsequently attenuate the p53 pathway. Its role in regulating the human response to acute illness has not been reported. Methods Patients from the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704b9ab674639904c93872178495e0fe
https://pubmed.ncbi.nlm.nih.gov/18558393
https://pubmed.ncbi.nlm.nih.gov/18558393