Výsledky vyhledávání - "Jacqueline E. Baumgartner"

BRAFV600E Mutation Is Associated with Preferential Sensitivity to Mitogen-Activated Protein Kinase Kinase Inhibition in Thyroid Cancer Cell Lines

Autor: Rebecca Leboeuf, Miriam Benezra, Christine A. Pratilas, Jeffrey A. Knauf, Jacqueline E. Baumgartner, David B. Solit, Roberta Malaguarnera, James A. Fagin, Neal Rosen

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 93:2194-2201

Context: Mutually exclusive mutations of RET, RAS, or BRAF are present in about 70% of papillary thyroid carcinomas, whereas only the latter two are seen in poorly differentiated and anaplastic cancers. Although the signal output common to these onco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f32f400aa935be308dd6282c8e25c5
https://doi.org/10.1210/jc.2007-2825

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RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR

Autor: Heidi Lane, Xu Chen, Doriano Fabbro, Michelle L. Croyle, James A. Fagin, Jeffrey A. Knauf, Jacqueline E. Baumgartner, Nagako Akeno

Publikováno v: Cancer research. 68(11)

RET/PTC rearrangements are one of the genetic hallmarks of papillary thyroid carcinomas. RET/PTC oncoproteins lack extracellular or transmembrane domains, and activation takes place through constitutive dimerization mediated through coiled-coil motif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8807d2ad6d19d8246ce7df1ade0d1b
https://pubmed.ncbi.nlm.nih.gov/18519677

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