Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jacqueline D. Welter"'
Autor:
Jeewoo Lee, Mi-Kyoung Jin, Sang-Uk Kang, Su Yeon Kim, Jiyoun Lee, Myoungyoup Shin, Jaemin Hwang, Sookhyun Cho, Yeon-Sil Choi, Hyun-Kyung Choi, Sung-Eun Kim, Young-Ger Suh, Yong-Sil Lee, Young-Ho Kim, Hee-Jin Ha, Attila Toth, Larry V. Pearce, Richard Tran, Tamas Szabo, Jacqueline D. Welter, Daniel J. Lundberg, Yun Wang, Jozsef Lazar, Vladimir A. Pavlyukovets, Matthew A. Morgan, Peter M. Blumberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4143-4150
The structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. A docking model of potent antagonist 2 with the sensor region of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ecd7ad003517bb0254825324865145
https://doi.org/10.1016/j.bmcl.2005.06.006
https://doi.org/10.1016/j.bmcl.2005.06.006
Autor:
Jeewoo Lee, Young-Ger Suh, Richard Tran, Peter M. Blumberg, Jacqueline D. Welter, Attila Tóth, Yun Wang, Jiyoun Lee, Tamás Szabó, Sang Uk Kang
Publikováno v:
Molecular Pharmacology. 62:947-956
The vanilloid receptor VR1 has attracted great interest as a sensory transducer for capsaicin, protons, and heat, and as a therapeutic target. Here we characterize two novel VR1 antagonists, KJM429 [N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e9813889e47e7f3f783a7428ebe09a
https://doi.org/10.1124/mol.62.4.947
https://doi.org/10.1124/mol.62.4.947
Autor:
Attila Tóth, Min-Jung Kil, Young Ho Kim, Jacqueline D. Welter, Myoungyoup Shin, Matthew A. Morgan, Jeewoo Lee, Peter M. Blumberg, Su-Yeon Kim, Sungeun Kim, Ju-Ok Lim, Hee-Jin Ha, Kyung-Hoon Min, Hyun-Kyung Choi, Sang-Uk Kang, Yong-Sil Lee, Larry V. Pearce, Yun Wang, Tamás Szabó, Vladimir A. Pavlyukovets, Daniel J. Lundberg, Richard Tran, Mi-Kyoung Jin
The structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. The 2-halogen analogues showed enhanced antagonism compared to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b60f24408d624d5a9144ddaf89b1205
Autor:
Su-Yeon Kim, Ji-Min Kim, Tamás Szabó, Attila Tóth, Jiyoun Lee, Jeewoo Lee, Soyoung Park, Ju-Ok Lim, Jacqueline D. Welter, Hyun-Kyung Choi, Mi-Kyung Jin, Larry V. Pearce, Peter M. Blumberg, Richard Tran, Sang-Uk Kang, Myungshim Kang
Publikováno v:
Bioorganicmedicinal chemistry. 12(5)
We previously described a series of N-(3-acyloxy-2-benzylpropyl) homovanillate and N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives that were potent VR1 agonists with high-affinities and excellent analgesic profiles. The design of these simplified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2b7a7ebac1ac5a0b8a1423cfdd2121
https://pubmed.ncbi.nlm.nih.gov/14980619
https://pubmed.ncbi.nlm.nih.gov/14980619
Autor:
Richard Tran, Peter M. Blumberg, Jiyoun Lee, Jacqueline D. Welter, Jeewoo Lee, Sang-Uk Kang, Yun Wang, Ju-Ok Lim, Tamás Szabó, Attila Tóth
Publikováno v:
Molecular pharmacology. 64(2)
The vanilloid receptor VR1 is a polymodal nociceptor sensitive to capsaicin, protons, and heat. Because VR1 represents an attractive therapeutic target for conditions ranging from long-term pain to bladder hyperreflexia, we and other groups have soug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f336b170b336ecfb873cda80be4aab84
https://pubmed.ncbi.nlm.nih.gov/12869637
https://pubmed.ncbi.nlm.nih.gov/12869637
Autor:
Jeewoo Lee, Tamás Szabó, Adamar F Gonzalez, Peter M. Blumberg, Jacqueline D. Welter, Jiyoun Lee
Publikováno v:
Bioorganicmedicinal chemistry. 9(7)
The vanilloid receptor represents a promising target for drug development. Building on our previous strategies which have generated potent agonists for VR1, we now describe a series of novel N -(3-acyloxy-2-benzylpropyl)- N′ -dihydroxytetrahydroben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0620d2279b131efe73cc4d002f6714
https://pubmed.ncbi.nlm.nih.gov/11425572
https://pubmed.ncbi.nlm.nih.gov/11425572