Raltegravir Inclusion Decreases CD4 T-Cells Intra-Cellular Viral Load and Increases CD4 and CD28 Positive T-Cells in Selected HIV Patients

Autor: Gaurav Kumar, Jacqueline Cottalorda-Dufayard, Rodolphe Garraffo, Francine De Salvador-Guillouët, Eric Cua, Pierre-Marie Roger

Publikováno v: Cells, Vol 11, Iss 2, p 208 (2022)

Raltegravir (RLT) prevents the integration of HIV DNA in the nucleus, but published studies remain controversial, suggesting that it does not decrease proviral DNA. However, there are only a few studies focused on virus-targeted cells. We aimed our s

Externí odkaz: https://doaj.org/article/912eb47b0b144f27b44fad18692fd397

HMGB1/anti-HMGB1 antibodies define a molecular signature of early stages of HIV-Associated Neurocognitive Disorders (HAND)

Autor: Marie-Lise Gougeon, Béatrice Poirier-Beaudouin, Jacques Durant, Christine Lebrun-Frenay, Héla Saïdi, Valérie Seffer, Michel Ticchioni, Stephane Chanalet, Helene Carsenti, Alexandra Harvey-Langton, Muriel Laffon, Jacqueline Cottalorda, Christian Pradier, Pierre Dellamonica, Matteo Vassallo

Publikováno v: Heliyon, Vol 3, Iss 2, Pp e00245- (2017)

Background: HIV-associated neurocognitive disorders (HAND) persist in the post-HAART era, characterized by asymptomatic neurocognitive impairment (ANI) and mild neurocognitive disorders (MND). High mobility group box 1 (HMGB1) is a non-histone chromo

Externí odkaz: https://doaj.org/article/0589c599a7554d9f8db1a2b947d4be38

A decreasing CD4/CD8 ratio over time and lower CSF-penetrating antiretroviral regimens are associated with a higher risk of neurocognitive deterioration, independently of viral replication

Autor: Brigitte Dunais, Jacqueline Cottalorda, Michel Ticchioni, Heloise Joly, Matteo Vassallo, Alexandra Harvey-Langton, Christine Lebrun-Frenay, M. Laffon, Jacques Durant, F DeSalvador, Pierre Dellamonica, C. Pradier, Roxane Fabre

Publikováno v: Journal of NeuroVirology. 23:216-225

Persistent immune activation is one of the suspected causes of HIV-associated neurocognitive disorders (HAND) in cART era. The CD4/CD8 ratio has been recently showed as a marker of immune activation and HAND. Our aim was to analyze if a decrease in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf429c1c02fa9520086e73235240336
https://doi.org/10.1007/s13365-016-0490-z

Levels of intracellular HIV-DNA in patients with suppressive antiretroviral therapy

Autor: Lise, Cuzin, Pascal, Pugliese, Karine, Sauné, Clotilde, Allavena, Jade, Ghosn, Jacqueline, Cottalorda, Audrey, Rodallec, Marie Laure, Chaix, Samira, Fafi-Kremer, Cathia, Soulié, Marlène, Ouka, Charlotte, Charpentier, Laurence, Bocket, Audrey, Mirand, Marguerite, Guiguet, S, Casanova

Publikováno v: AIDS
AIDS, Lippincott, Williams & Wilkins, 2015, 29 (13), pp.1665-1671. ⟨10.1097/QAD.0000000000000723⟩
AIDS. Official journal of the international AIDS Society
AIDS. Official journal of the international AIDS Society, 2015, 29 (13), pp.1665-1671. ⟨10.1097/QAD.0000000000000723⟩

OBJECTIVE The objective of this study is to study factors associated with HIV-DNA levels in chronically infected patients on long-term suppressive antiretroviral therapy (ART). DESIGN A cross-sectional, multicentre study of patients receiving ART for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef640361d3b28112860a722090da7d0
https://doi.org/10.1097/qad.0000000000000723

HIV-1-infected patients from the French National Observatory experiencing virological failure while receiving enfuvirtide

Autor: Virginie Ferré, Jacqueline Cottalorda, Anne-Geneviève Marcelin, Véronique Schneider, Laurence Morand-Joubert, Jacques Izopet, Diane Descamps, Lambert Assoumou, Coralie Pallier, Souhila Saidi, Bernard Masquelier, Marie-Laure Chaix, Annick Ruffault, Constance Delaugerre, Vincent Calvez, Sabine Yerly, Françoise Brun-Vézinet, Jean-Christophe Plantier, Gilles Peytavin, Brigitte Montes, Dominique Costagliola, Catherine Tamalet

Objectives: We studied gp41 mutations associated with failing enfuvirtide salvage therapy. Methods: This multicentre study involved patients with HIV-1 plasma viral load (pVL) > 5000 copies/mL after at least 3 months of uninterrupted enfuvirtide ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b4f25a4aace439ef05c74e2eaa0df0
http://doc.rero.ch/record/295629/files/dkn225.pdf