Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jacqueline Cobbert"'
Autor:
Sergey Reverdatto, Christopher M. DeMott, Roxie C. Girardin, Alexander Shekhtman, David S. Burz, Jacqueline Cobbert, Kathleen A. McDonough
Publikováno v:
ACS Chemical Biology. 13:733-741
In-cell NMR spectroscopy was used to screen for drugs that disrupt the interaction between prokaryotic ubiquitin like protein, Pup, and mycobacterial proteasome ATPase, Mpa. This interaction is critical for Mycobacterium tuberculosis resistance again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463c8d63332fd3c622d211f882a5cccd
https://doi.org/10.1021/acschembio.7b00879
https://doi.org/10.1021/acschembio.7b00879
Autor:
Ankit Gupta, Frank Sicheri, Dianicha Santana, Matthew J. Smith, Raphael R. Eguchi, Erika Herrero-Garcia, Yong Zhou, Evan Dowdell, Marc Therrien, Mustafa Nazir Okur, Irina Dementieva, Hugo Lavoie, Miranda Jacobs, Akiko Koide, John P. O'Bryan, Russell Spencer-Smith, Fern Sha, Priyanka Gajwani, Jacqueline Cobbert, John F. Hancock, Mitsuhiko Ikura, Shohei Koide, Thanashan Rajakulendran
Publikováno v:
Nat Chem Biol
RAS GTPases are important mediators of oncogenesis in humans. However, pharmacological inhibition of RAS has proved challenging. Here we describe a functionally critical region, located outside the effector lobe of RAS, that can be targeted for inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f640a6df2e18e8d7ba330903a340f5
https://europepmc.org/articles/PMC5193369/
https://europepmc.org/articles/PMC5193369/
