Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jacqueline C. Ruiz"'
Autor:
Kenneth C. Lewis, Jill Schreiwer, James R. Beadle, Jacqueline C. Ruiz, R. Mark L. Buller, Karl Y. Hostetler, Kathy A. Keith, Mark N. Prichard
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:2950-2958
Alkoxyalkyl esters of cidofovir (CDV) are orally active agents which inhibit the replication of a variety of double stranded DNA (dsDNA) viruses including variola, vaccinia, ectromelia, herpes simplex virus, cytomegalovirus, adenovirus and others. On
Autor:
Jacqueline C. Ruiz, Kathy A. Aldern, Earl R. Kern, Karl Y. Hostetler, Kathy A. Keith, James R. Beadle, Caroll B. Hartline
Publikováno v:
Antiviral Research. 75:87-90
Esterification of cidofovir (CDV), an antiviral nucleoside phosphonate, with alkyl or alkoxyalkyl groups increases antiviral activity by enhancing cell uptake and conversion to CDV diphosphate. Hexadecyloxypropyl-CDV (HDP-CDV) has been shown to be 40
Autor:
Karl Y. Hostetler, Jacqueline C. Ruiz, Caroll B. Hartline, James R. Beadle, Earl R. Kern, Kathy A. Aldern
Publikováno v:
Antiviral chemistrychemotherapy. 17(2)
Phosphonopropoxymethyl-guanine is the methylene phosphonate analogue of acyclovir. Although not highly active against HSV, 4–38 µM of phosphonopropoxymethyl-guanine has been reported to be active against human and murine cytomegalovirus. Recently
Publikováno v:
Antiviral Research. 86:A66