Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Jacqueline Bromberg"'
Autor:
Antonio Strillacci, Pasquale Sansone, Vinagolu K. Rajasekhar, Mesruh Turkekul, Vitaly Boyko, Fanli Meng, Brian Houck-Loomis, David Brown, Michael F. Berger, Ronald C. Hendrickson, Qing Chang, Elisa de Stanchina, Fresia Pareja, Jorge S. Reis-Filho, Ramya Segu Rajappachetty, Isabella Del Priore, Bo Liu, Yanyan Cai, Alex Penson, Chiara Mastroleo, Marjan Berishaj, Francesca Borsetti, Enzo Spisni, David Lyden, Sarat Chandarlapaty, Jacqueline Bromberg
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is
Externí odkaz:
https://doaj.org/article/f78ea24d939745a8868b8fcd4d4bff37
Autor:
Babak J. Mehrara, Hyeung Ju Park, Raghu P. Kataru, Jacqueline Bromberg, Michelle Coriddi, Jung Eun Baik, Jinyeon Shin, Claire Li, Michele R. Cavalli, Elizabeth M. Encarnacion, Meghan Lee, Kimberly J. Van Zee, Elyn Riedel, Joseph H. Dayan
Publikováno v:
Biology, Vol 10, Iss 9, p 934 (2021)
Recent studies suggest that Th2 cells play a key role in the pathology of secondary lymphedema by elaborating cytokines such as IL4 and IL13. The aim of this study was to test the efficacy of QBX258, a monoclonal IL4/IL13 neutralizing antibody, in wo
Externí odkaz:
https://doaj.org/article/6eb7b3a1febd4c0fa84343f86e381363
Autor:
Pasquale Sansone, Claudio Ceccarelli, Marjan Berishaj, Qing Chang, Vinagolu K. Rajasekhar, Fabiana Perna, Robert L. Bowman, Michele Vidone, Laura Daly, Jennifer Nnoli, Donatella Santini, Mario Taffurelli, Natalie N. C. Shih, Michael Feldman, Jun J. Mao, Christopher Colameco, Jinbo Chen, Angela DeMichele, Nicola Fabbri, John H. Healey, Monica Cricca, Giuseppe Gasparre, David Lyden, Massimiliano Bonafé, Jacqueline Bromberg
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
ER+ breast cancer patients treated with endocrine therapies often acquire resistance and develop metastasis. In this study, the authors demonstrate that endocrine therapies can promote the self-renewal of CD133hi/ERlodrug resistant cells with metasta
Externí odkaz:
https://doaj.org/article/0f73773c836b47a9b54b97e9c2ac1634
Autor:
Qing Chang, Eirini Bournazou, Pasquale Sansone, Marjan Berishaj, Sizhi Paul Gao, Laura Daly, Jared Wels, Till Theilen, Selena Granitto, Xinmin Zhang, Jesse Cotari, Mary L. Alpaugh, Elisa de Stanchina, Katia Manova, Ming Li, Massimiliano Bonafe, Claudio Ceccarelli, Mario Taffurelli, Donatella Santini, Gregoire Altan-Bonnet, Rosandra Kaplan, Larry Norton, Norihiro Nishimoto, Dennis Huszar, David Lyden, Jacqueline Bromberg
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 7, Pp 848-862 (2013)
We have investigated the importance of interleukin-6 (IL-6) in promoting tumor growth and metastasis. In human primary breast cancers, increased levels of IL-6 were found at the tumor leading edge and positively correlated with advanced stage, sugges
Externí odkaz:
https://doaj.org/article/b7e0970a4f474c2bbf86725441c9b2be
Autor:
Janeen Azare, Ashley Doane, Kenneth Leslie, Qing Chang, Marjan Berishaj, Jennifer Nnoli, Kevin Mark, Hikmat Al-Ahmadie, William Gerald, Maryam Hassimi, Agnes Viale, Mary Stracke, David Lyden, Jacqueline Bromberg
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27851 (2011)
We determined that signal transducer and activator of transcription 3 (Stat3) is tyrosine phosphorylated in 37% of primary breast tumors and 63% of paired metastatic axillary lymph nodes. Examination of the distribution of tyrosine phosphorylated (pS
Externí odkaz:
https://doaj.org/article/9ba590145ac748df97b18c28a44fa8d7
Autor:
Gang Wang, Jianlong Li, Linda Bojmar, Haiyan Chen, Zhong Li, Gabriel C. Tobias, Mengying Hu, Edwin A. Homan, Serena Lucotti, Fengbo Zhao, Valentina Posada, Peter R. Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, Nancy Boudreau, Zhanjun Shi, Christin E. Burd, Jonathan H. Zippin, James C. Lo, Geoffrey S. Pitt, Jonathan Hernandez, Constantinos P. Zambirinis, Michael A. Hollingsworth, Paul M. Grandgenett, Maneesh Jain, Surinder K. Batra, Dominick J. DiMaio, Jean L. Grem, Kelsey A. Klute, Tanya M. Trippett, Mikala Egeblad, Doru Paul, Jacqueline Bromberg, David Kelsen, Vinagolu K. Rajasekhar, John H. Healey, Irina R. Matei, William R. Jarnagin, Robert E. Schwartz, Haiying Zhang, David Lyden
Publikováno v:
Nature.
Autor:
Ross L. Levine, Rong Fan, Franziska Michor, Thomas Radimerski, Masato Murakami, Julie Teruya-Feldstein, Jacqueline Bromberg, Jordan S. Fridman, Vincent Romanet, Jonathan J. Chen, Sachie Marubayashi, Raajit Rampal, Omar Abdel-Wahab, Efthymia Papalexi, Anna Sophia McKenney, Neha Bhagwat, Todd Hricik, Lennart Bastian, Matthew Keller, Markus Riester, Priya Koppikar, Minsuk Kwak, Maria Kleppe
Supplementary Figure 1. Pro-inflammatory cytokines are elevated in MF mice and reversed with JAK inhibitor treatment. Supplementary Figure 2. Principal component analysis of MF cells. Supplementary Figure 3. Single cell analysis of immunophenotypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0739c902c6e921c3e4e3ab17e50ad9dd
https://doi.org/10.1158/2159-8290.22530627
https://doi.org/10.1158/2159-8290.22530627
Supplemental Figure 2 from First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer
Autor:
Steven M. Larson, Jason S. Lewis, Gabriela Chiosis, Hanwen Zhang, Josef J. Fox, Heiko M. Schöder, Jacqueline Bromberg, Clifford A. Hudis, Serge K. Lyashchenko, Eva M. Burnazi, Mohammad M. Uddin, Stefan O. Ochiana, Tony Taldone, Danuta Zatorska, Pat B. Zanzonico, Bradley J. Beattie, Larry Norton, Komal Jhaveri, Shanu Modi, Milan Grkovski, Nagavarakishore Pillarsetty, Christina Pressl, Mark P.S. Dunphy
Supplemental Figure 2. Tumor PU-H71 retention at 24 hours post-injection (quantified by standard uptake value) is not explained by plasma radiotracer exposure (quantified by plasma AUC from 10 min to 4 h post-injection, see Methods), as indicated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8112ce39ee10426f23c28886ea84aa71
https://doi.org/10.1158/1078-0432.22477815.v1
https://doi.org/10.1158/1078-0432.22477815.v1
Supplemental Figure 1 from First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer
Autor:
Steven M. Larson, Jason S. Lewis, Gabriela Chiosis, Hanwen Zhang, Josef J. Fox, Heiko M. Schöder, Jacqueline Bromberg, Clifford A. Hudis, Serge K. Lyashchenko, Eva M. Burnazi, Mohammad M. Uddin, Stefan O. Ochiana, Tony Taldone, Danuta Zatorska, Pat B. Zanzonico, Bradley J. Beattie, Larry Norton, Komal Jhaveri, Shanu Modi, Milan Grkovski, Nagavarakishore Pillarsetty, Christina Pressl, Mark P.S. Dunphy
Supplemental Figure 1. Tumor retention of PU-H71 tracer varied considerably between patients. Tumor retention expressed as tumor:bloodpool SUV ratio (y-axis) measured on PET at 4 and 24 hours post tracer-injection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951f22e47aec50efd05d77b9ce89c91c
https://doi.org/10.1158/1078-0432.22477818.v1
https://doi.org/10.1158/1078-0432.22477818.v1
Supplemental Figure 3 from First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer
Autor:
Steven M. Larson, Jason S. Lewis, Gabriela Chiosis, Hanwen Zhang, Josef J. Fox, Heiko M. Schöder, Jacqueline Bromberg, Clifford A. Hudis, Serge K. Lyashchenko, Eva M. Burnazi, Mohammad M. Uddin, Stefan O. Ochiana, Tony Taldone, Danuta Zatorska, Pat B. Zanzonico, Bradley J. Beattie, Larry Norton, Komal Jhaveri, Shanu Modi, Milan Grkovski, Nagavarakishore Pillarsetty, Christina Pressl, Mark P.S. Dunphy
Tumor PU-H71 retention at 24 hours post-injection (quantified by standard uptake value) is not explained by plasma radiotracer exposure (quantified by plasma AUC from 10 min to 4 h post-injection, see Methods), as indicated by Spearman Test R-value.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cecc57205e1427af5a87a0a2522a0a8
https://doi.org/10.1158/1078-0432.22477812.v1
https://doi.org/10.1158/1078-0432.22477812.v1