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pro vyhledávání: '"Jacqueline Boutilier"'
Autor:
Kenneth E. Neet, Claire Ceni, Alison Forgie, Promila C. Pagdala, Jacqueline Boutilier, Philip A. Barker
Publikováno v:
Journal of Biological Chemistry. 283:12709-12716
The uncleaved, pro-form of nerve growth factor (proNGF) functions as a pro-apoptotic ligand for the p75 neurotrophin receptor (p75NTR). However, some reports have indicated that proneurotrophins bind and activate Trk receptors. In this study, we have
Autor:
Wai Chi Ho, Stephanie Forte, Philip A. Barker, Kristy Favell, Kathleen M. Dickson, Jacqueline Boutilier, Alberto Javier Ramos
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(6)
Injury-induced expression of the p75 neurotrophin receptor (p75NTR) in the CNS facilitates neuronal apoptosis and prevents neuronal regrowth, but the mechanisms regulating p75NTR expression are poorly characterized. In this study, we showed that hypo