Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jacqueline A. Reilly"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1645-1650 (2014)
A set of bisphosphonate ethers has been prepared through sequential phosphonylation and alkylation of monophosphonate ethers. After formation of the corresponding phosphonic acid salts, these compounds were tested for their ability to inhibit the enz
Externí odkaz:
https://doaj.org/article/2ec554d6ade84a82ba9ffcbd17bc559f
RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth
Autor:
Jussara Hagen, Timothy Ginader, Abbey L. Perl, Terry A. Braun, Gideon K. D. Zamba, Bart J. Brown, Dawn E. Quelle, James R. Howe, Jacqueline A. Reilly, Goutham Narla, Benjamin W. Darbro, Fenghuang Zhan, Angela M. Schab, Aaron T. Scott, Blake L. Letney, Jordan L. Kohlmeyer, Courtney A. Kaemmer, Shaikamjad Umesalma, Joseph S. Dillon, David K. Meyerholz, Mariah R. Leidinger, Stefan Strack, Thomas M. O'Dorisio, Andrew M. Bellizzi, Agshin F. Taghiyev, Frederick W. Quelle, Nitija Tiwari, Ronald A. Merrill, Ryan M. Sheehy
Publikováno v:
Journal of Clinical Investigation. 129:1641-1653
Hyperactivated AKT/mTOR signaling is a hallmark of pancreatic neuroendocrine tumors (PNETs). Drugs targeting this pathway are used clinically, but tumor resistance invariably develops. A better understanding of factors regulating AKT/mTOR signaling a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232bebbf58142beac4d6bf84a1f8bff8
https://doi.org/10.1172/jci123049
https://doi.org/10.1172/jci123049
Publikováno v:
Cancer Biology & Therapy
The isoprenoid biosynthetic pathway (IBP) plays a critical role in providing substrates and enzymes necessary for the post-translational modification and thus activation of a number of proteins involved in prostate cancer metastasis. Previous work by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926589807092ffb0f1fe34eda56b51b1
https://doi.org/10.1080/15384047.2016.1219817
https://doi.org/10.1080/15384047.2016.1219817
Publikováno v:
The Prostate. 79(1)
Background Following androgen deprivation for the treatment of advanced adenocarcinoma of the prostate, tumors can progress to neuroendocrine prostate cancer (NEPC). This transdifferentiation process is poorly understood, but trafficking of transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e75b0622a65976902c35fe4bde11ca
https://pubmed.ncbi.nlm.nih.gov/30106164
https://pubmed.ncbi.nlm.nih.gov/30106164
Autor:
Jacqueline E. Reilly, David F. Wiemer, Huaxiang Tong, Craig H. Kuder, Raymond J. Hohl, Xiang Zhou
Publikováno v:
Biochemical Pharmacology. 96:83-92
A small set of isoprenoid bisphosphonates ethers have been tested in the K562 chronic myelogenous leukemia cell line to determine their impact on isoprenoid biosynthesis. Five of these compounds inhibit geranylgeranyl diphosphate synthase (GGDPS) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0c514e452a150436f6ed6a91c9e009
https://doi.org/10.1016/j.bcp.2015.04.009
https://doi.org/10.1016/j.bcp.2015.04.009
Publikováno v:
Clinical & Experimental Metastasis. 32:555-566
The isoprenoid biosynthetic pathway (IBP) is critical for providing substrates for the post-translational modification of proteins key in regulating malignant cell properties, including proliferation, invasion, and migration. Inhibitors of the IBP, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e995efcebbe2e73a53fff6ce9b8b7e6d
https://doi.org/10.1007/s10585-015-9727-0
https://doi.org/10.1007/s10585-015-9727-0
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1645-1650 (2014)
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1645-1650 (2014)
A set of bisphosphonate ethers has been prepared through sequential phosphonylation and alkylation of monophosphonate ethers. After formation of the corresponding phosphonic acid salts, these compounds were tested for their ability to inhibit the enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609ea15ee56bd7d29405931aedcd8435
http://europepmc.org/articles/PMC4142842
http://europepmc.org/articles/PMC4142842
Publikováno v:
Tetrahedron Letters. 52:5512-5515
This study examined whether commercially available diazonium salts could be used as efficient aromatic azide precursors in one-pot multi-step click transformations. Seven different diazonium salts, including Fast Red RC, Fast Blue B, Fast Corinth V a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8fb13b4104d2a621b629f8e3e2e781
https://doi.org/10.1016/j.tetlet.2011.08.069
https://doi.org/10.1016/j.tetlet.2011.08.069
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0df0f49a3b4c808422e818c13ed2962
https://doi.org/10.1096/fasebj.27.1_supplement.1105.22
https://doi.org/10.1096/fasebj.27.1_supplement.1105.22