Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jacqueline A. M. Smith"'
Autor:
Panayiotis Anastasiou, Christopher Moore, Sareena Rana, Mona Tomaschko, Claire E. Pillsbury, Andrea de Castro, Jesse Boumelha, Edurne Mugarza, Sophie de Carné Trécesson, Ania Mikolajczak, Cristina Blaj, Robert Goldstone, Jacqueline A. M. Smith, Elsa Quintana, Miriam Molina-Arcas, Julian Downward
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mutant selective drugs targeting the inactive, GDP-bound form of KRASG12C have been approved for use in lung cancer, but resistance develops rapidly. Here we use an inhibitor, (RMC-4998) that targets RASG12C in its active, GTP-bound form, to
Externí odkaz:
https://doaj.org/article/f04ce583c0fc4b438b6298469e1bd117
Autor:
Hidenori Kitai, Philip H. Choi, Yu C. Yang, Jacob A. Boyer, Adele Whaley, Priya Pancholi, Claire Thant, Jason Reiter, Kevin Chen, Vladimir Markov, Hirokazu Taniguchi, Rui Yamaguchi, Hiromichi Ebi, James Evans, Jingjing Jiang, Bianca Lee, David Wildes, Elisa de Stanchina, Jacqueline A. M. Smith, Mallika Singh, Neal Rosen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Current KRASG12C (OFF) inhibitors that target inactive GDP-bound KRASG12C cause responses in less than half of patients and these responses are not durable. A class of RASG12C (ON) inhibitors that targets active GTP-bound KRASG12C blocks ERK
Externí odkaz:
https://doaj.org/article/7ad6de68f66945a2a3cb9c50ceaaf9b5
Autor:
Bianca J. Lee, Sharmila Mallya, Nuntana Dinglasan, Amos Fung, Tram Nguyen, Lee-or Herzog, Joshua Thao, Edward G. Lorenzana, David Wildes, Mallika Singh, Jacqueline A. M. Smith, David A. Fruman
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The mechanistic target of rapamycin (mTOR) is a kinase whose activity is elevated in hematological malignancies. mTOR-complex-1 (mTORC1) phosphorylates numerous substrates to promote cell proliferation and survival. Eukaryotic initiation factor 4E (e
Externí odkaz:
https://doaj.org/article/0ce53ca3736040b0b923689cf9147f19
Autor:
G. Leslie Burnett, Yu C. Yang, James B. Aggen, Jennifer Pitzen, Micah K. Gliedt, Chris M. Semko, Abby Marquez, James W. Evans, Gang Wang, Walter S. Won, Aidan C. A. Tomlinson, Gert Kiss, Christos Tzitzilonis, Arun P. Thottumkara, James Cregg, Kevin T. Mellem, Jong S. Choi, Julie C. Lee, Yongyuan Zhao, Bianca J. Lee, Justin G. Meyerowitz, John E. Knox, Jingjing Jiang, Zhican Wang, David Wildes, Zhengping Wang, Mallika Singh, Jacqueline A. M. Smith, Adrian L. Gill
Publikováno v:
Journal of Medicinal Chemistry. 66:149-169
Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk with other mutant cancer drivers, such as RAS, is a feature of many tumors. Multiple allosteric inhibitors of mTORC1 and orthosteric dual inhibitors of mTORC1 and mT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cb750ad287b7aa33c649c1e4fa24c0
https://doi.org/10.1021/acs.jmedchem.2c01658
https://doi.org/10.1021/acs.jmedchem.2c01658
Autor:
Darienne R. Myers, Clare L. Abram, David Wildes, Amira Belwafa, Alia M. N. Welsh, Christopher J. Schulze, Tiffany J. Choy, Tram Nguyen, Neil Omaque, Yongmei Hu, Mallika Singh, Rich Hansen, Mark A. Goldsmith, Elsa Quintana, Jacqueline A. M. Smith, Clifford A. Lowell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Shp1, encoded by the gene Ptpn6, is a protein tyrosine phosphatase that transduces inhibitory signals downstream of immunoreceptors in many immune cell types. Blocking Shp1 activity represents an exciting potential immunotherapeutic strategy for the
Externí odkaz:
https://doaj.org/article/2cbd737225784d23b6606ab275c55b74
Autor:
Wadie D. Mahauad-Fernandez, Yu Chi Yang, Ian Lai, Jangho Park, Lilian Yao, James W. Evans, G. Leslie Burnett, Adrian Gill, Jacqueline A. M. Smith, Mallika Singh, Dean W. Felsher
The MYC oncogene is causally involved in the pathogenesis of most types of human cancer but it remains therapeutically untargeted. The mTORC1 protein complex regulates cap-dependent translation through 4EBP1 and S6K and thereby, downstream MYC protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::762aeb40e19f766b9975737084ec8a14
https://doi.org/10.1101/2022.02.04.478208
https://doi.org/10.1101/2022.02.04.478208
Autor:
Susan Ludmann, John Paul Thottam, Sara Carlson, Tanya Grancharova, Kaytlyn Gerbin, Jacqueline A. M. Smith, Antoine Borenzstejn, Jamie Gehring, Margaret A. Fuqua, Stephanie Dinh, Youngmee Sul, Rebecca Zaunbrecher, Amanda Haupt, Susanne M. Rafelski, Christopher L. Frick, Daniel Toloudis, Graham Johnson, Angelique Nelson, Brock Roberts, Ru Gunawardane, Joy Arakaki, Irina Mueller, Caroline Hookway
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86c9fdc3030fcdd910cafcdd2feac919
https://doi.org/10.1096/fasebj.2021.35.s1.05486
https://doi.org/10.1096/fasebj.2021.35.s1.05486
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74891 (2013)
Multimodal analgesia is designed to optimize pain relief by coadministering drugs with distinct mechanisms of action or by combining multiple pharmacologies within a single molecule. In clinical settings, combinations of monoamine reuptake inhibitors
Externí odkaz:
https://doaj.org/article/d3fddfb81dfd41c7b5dcacc1b0910695
Autor:
Bianca J. Lee, Jacob A. Boyer, G. Leslie Burnett, Arun P. Thottumkara, Nidhi Tibrewal, Stacy L. Wilson, Tientien Hsieh, Abby Marquez, Edward G. Lorenzana, James W. Evans, Laura Hulea, Gert Kiss, Hui Liu, Dong Lee, Ola Larsson, Shannon McLaughlan, Ivan Topisirovic, Zhengping Wang, Zhican Wang, Yongyuan Zhao, David Wildes, James B. Aggen, Mallika Singh, Adrian L. Gill, Jacqueline A. M. Smith, Neal Rosen
Publikováno v:
Nature Chemical Biology. 17:1209-1209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87895925246afc37728a83e10bf0992b
https://doi.org/10.1038/s41589-021-00905-4
https://doi.org/10.1038/s41589-021-00905-4
Publikováno v:
European Journal of Neuroscience. 12:3250-3258
Primary cultures of neonatal rat dorsal root ganglion (DRG) neurons were used to examine the mechanisms underlying both the direct activation and the sensitization of sensory neurons by prostanoids. Prostaglandin E2 (PGE2) elevated cytosolic calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::014d8e31a0de69b21f1d2bd4a8107390
https://doi.org/10.1046/j.1460-9568.2000.00218.x
https://doi.org/10.1046/j.1460-9568.2000.00218.x