Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Jacqueline A. Brosnan"'
Autor:
Michael Griffin, Aaron M. Gruver, Chintan Shah, Qasim Wani, Darren Fahy, Archit Khosla, Christian Kirkup, Daniel Borders, Jacqueline A. Brosnan-Cashman, Angie D. Fulford, Kelly M. Credille, Christina Jayson, Fedaa Najdawi, Klaus Gottlieb
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Histological assessment is essential for the diagnosis and management of celiac disease. Current scoring systems, including modified Marsh (Marsh–Oberhuber) score, lack inter-pathologist agreement. To address this unmet need, we aimed to d
Externí odkaz:
https://doaj.org/article/c6797331dcd94b2584d46f440ddf3220
Autor:
John Abel, Suyog Jain, Deepta Rajan, Harshith Padigela, Kenneth Leidal, Aaditya Prakash, Jake Conway, Michael Nercessian, Christian Kirkup, Syed Ashar Javed, Raymond Biju, Natalia Harguindeguy, Daniel Shenker, Nicholas Indorf, Darpan Sanghavi, Robert Egger, Benjamin Trotter, Ylaine Gerardin, Jacqueline A. Brosnan-Cashman, Aditya Dhoot, Michael C. Montalto, Chintan Parmar, Ilan Wapinski, Archit Khosla, Michael G. Drage, Limin Yu, Amaro Taylor-Weiner
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract While alterations in nucleus size, shape, and color are ubiquitous in cancer, comprehensive quantification of nuclear morphology across a whole-slide histologic image remains a challenge. Here, we describe the development of a pan-tissue, de
Externí odkaz:
https://doaj.org/article/e77f4d0737534fd0a960be835c387e68
Autor:
Fausto J. Rodriguez, Mindy K. Graham, Jacqueline A. Brosnan-Cashman, John R. Barber, Christine Davis, M. Adelita Vizcaino, Doreen N. Palsgrove, Caterina Giannini, Melike Pekmezci, Sonika Dahiya, Murat Gokden, Michael Noë, Laura D. Wood, Christine A. Pratilas, Carol D. Morris, Allan Belzberg, Jaishri Blakeley, Christopher M. Heaphy
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract The presence of Alternative lengthening of telomeres (ALT) and/or ATRX loss, as well as the role of other telomere abnormalities, have not been formally studied across the spectrum of NF1-associated solid tumors. Utilizing a telomere-specifi
Externí odkaz:
https://doaj.org/article/3454d938fe7347fc81ef6b72dd035460
Autor:
Bill H. Diplas, Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, Patrick J. Killela, Daniel B. Loriaux, Eric S. Lipp, Paula K. Greer, Rui Yang, Anthony J. Rizzo, Fausto J. Rodriguez, Allan H. Friedman, Henry S. Friedman, Sizhen Wang, Yiping He, Roger E. McLendon, Darell D. Bigner, Yuchen Jiao, Matthew S. Waitkus, Alan K. Meeker, Hai Yan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying
Externí odkaz:
https://doaj.org/article/dd48eac540f1490a9bb31a4f740711ca
Autor:
John Abel, Suyog Jain, Deepta Rajan, Harshith Padigela, Kenneth Leidal, Aaditya Prakash, Jake Conway, Michael Nercessian, Christian Kirkup, Syed Ashar Javed, Robert Egger, Benjamin Trotter, Ylaine Gerardin, Jacqueline A. Brosnan-Cashman, Aditya Dhoot, Michael C. Montalto, Ilan Wapinski, Archit Khosla, Michael G. Drage, Limin Yu, Amaro Taylor-Weiner
BackgroundAltered nuclei are ubiquitous in cancer, with changes in nuclear size, shape, and coloration accompanying cancer progression. However, comprehensive quantification of nuclear morphology across a whole-slide histologic image remains a challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c59ac25a98f713a20668d5539415ee5
https://doi.org/10.1101/2023.05.15.539600
https://doi.org/10.1101/2023.05.15.539600
Autor:
Onur Ertunc, Erica Smearman, Qizhi Zheng, Jessica L. Hicks, Jacqueline A. Brosnan-Cashman, Tracy Jones, Carolina Gomes-Alexandre, Levent Trabzonlu, Alan K. Meeker, Angelo M. De Marzo, Christopher M. Heaphy
Telomeres are terminal chromosomal elements that are essential for the maintenance of genomic integrity. The measurement of telomere content provides useful diagnostic and prognostic information, and fluorescent methods have been developed for this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ef1a1ba0a18aa40f37adf6313ce02f2
https://doi.org/10.1101/2023.04.04.535575
https://doi.org/10.1101/2023.04.04.535575
Autor:
Christopher M. Heaphy, Alan K. Meeker, Angelo M. De Marzo, Michael C. Haffner, Michael Considine, Leslie Cope, Qizhi Zheng, Christine Davis, Michael Rubenstein, Lionel Chia, Javier A. Baena Del Valle, Anthony Rizzo, Jacqueline A. Brosnan-Cashman, Joseph Da, Jiyoung Kim, Mindy K. Graham
Table S1. Sequences of oligonucleotides for CRISPR, telomere assays, and RT-qPCR. Table S2. Mean telomere lengths assessed from TRF southern blots of LAPC-4 EV and ATRXKO clones, and CWR22Rv1 EV and ATRXKO clones. Table S3. Microarray results of top
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52650f0d7f552024397c8accb09251af
https://doi.org/10.1158/1541-7786.22512513
https://doi.org/10.1158/1541-7786.22512513
Autor:
Christopher M. Heaphy, Alan K. Meeker, Angelo M. De Marzo, Michael C. Haffner, Michael Considine, Leslie Cope, Qizhi Zheng, Christine Davis, Michael Rubenstein, Lionel Chia, Javier A. Baena Del Valle, Anthony Rizzo, Jacqueline A. Brosnan-Cashman, Joseph Da, Jiyoung Kim, Mindy K. Graham
A key hallmark of cancer, unlimited replication, requires cancer cells to evade both replicative senescence and potentially lethal chromosomal instability induced by telomere dysfunction. The majority of cancers overcome these critical barriers by up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a4535a129772c3bc084407cc691c613
https://doi.org/10.1158/1541-7786.c.6540264.v1
https://doi.org/10.1158/1541-7786.c.6540264.v1
Autor:
Christopher M. Heaphy, Alan K. Meeker, Angelo M. De Marzo, Michael C. Haffner, Michael Considine, Leslie Cope, Qizhi Zheng, Christine Davis, Michael Rubenstein, Lionel Chia, Javier A. Baena Del Valle, Anthony Rizzo, Jacqueline A. Brosnan-Cashman, Joseph Da, Jiyoung Kim, Mindy K. Graham
Figure S1. LAPC-4 and CWR22RV1 are telomerase-positive ALT-negative cell lines. Figure S2. ATRXKOs were generated in LAPC-4 and CWR22Rv1 cells. Figure S3. Representative telomere restriction fragment (TRF) southern blots and signal intensity traces.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1174bb76c7833b38447b9d610482339a
https://doi.org/10.1158/1541-7786.22512522
https://doi.org/10.1158/1541-7786.22512522
Autor:
Christopher M. Heaphy, Alan K. Meeker, Angelo M. De Marzo, Michael C. Haffner, Michael Considine, Leslie Cope, Qizhi Zheng, Christine Davis, Michael Rubenstein, Lionel Chia, Javier A. Baena Del Valle, Anthony Rizzo, Jacqueline A. Brosnan-Cashman, Joseph Da, Jiyoung Kim, Mindy K. Graham
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d9f82887119202e65ea86f9c69c64c
https://doi.org/10.1158/1541-7786.22512519
https://doi.org/10.1158/1541-7786.22512519