Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jacqueline A Tickle"'
Autor:
Jacqueline A Tickle, Jon Sen, Christopher Adams, David N Furness, Rupert Price, Viswapathi Kandula, Nikolaos Tzerakis, Divya M Chari
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 5, Pp 1057-1061 (2023)
The use of live animal models for testing new therapies for brain and spinal cord repair is a controversial area. Live animal models have associated ethical issues and scientific concerns regarding the predictability of human responses. Alternative m
Externí odkaz:
https://doaj.org/article/fc1c757151c443d69fc5c2e6bdcffe83
Autor:
Jacqueline A. Tickle, Divya M. Chari
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 13:1732-1737
Genetic engineering of cell transplant populations offers potential for delivery of neurotherapeutic factors to modify the regenerative microenvironment of the injured spinal cord. The use of magnetic nanoparticle (MNP) based vectors has reduced the
Autor:
Jon Sen, Louise Finch, Jacqueline A. Tickle, Divya M. Chari, Nikolaos Tzerakis, Christopher F. Adams
Transplantation of neural stem cells (NSCs) into sites of neurological injury is being investigated in clinical trials around the world. These important self-renewing and multipotent precursors can generate the major central nervous system cell types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e572b1e32043e298735dbd646d83df
https://europepmc.org/articles/PMC6616718/
https://europepmc.org/articles/PMC6616718/
Autor:
Darren Carwardine, Nicolas Granger, Alexander M. Delaney, Jacqueline A. Tickle, Divya M. Chari, Christopher F. Adams
Publikováno v:
Macromolecular Bioscience
A recent clinical trial proved that autologous olfactory mucosal cell (OMC) transplantation improved locomotion in dogs with naturally occurring spinal injuries comparable to human lesions. However, not all dogs responded to the treatment, likely due
Publikováno v:
NANOMEDICINE
Aim: To develop a 3D neural cell construct for encapsulated delivery of transplant cells; develop hydrogels seeded with magnetic nanoparticle (MNP)-labeled cells suitable for cell tracking by MRI. Materials & methods: Astrocytes were exogenously labe
Autor:
Jon Sen, Divya M. Chari, Louise Finch, Sarah Harris, Jacqueline A. Tickle, Christopher F. Adams, Nikolaos Tzerakis
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 90:e7.2-e7
ObjectivesAchieving neural regeneration after spinal cord injury (SCI) represents a significant challenge. Neural stem cell (NSC) therapy offers replacement of damaged cells and delivery of pro-regenerative factors, but >95% of cells die when transpl
Aim: To achieve high and sustained magnetic particle loading in a proliferative and endocytotically active neural transplant population (astrocytes) through tailored magnetite content in polymeric iron oxide particles. Materials & methods: MPs of var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e91c8d38a13277d5a18c06bbd37be6
https://europepmc.org/articles/PMC4910955/
https://europepmc.org/articles/PMC4910955/
Autor:
Jacqueline A. Tickle, Shanthini Mahendrasingam, David N. Furness, Carole M. Hackney, Robert Fettiplace, Qingguo Chen
Publikováno v:
European Journal of Neuroscience. 36:2302-2310
Calcium is tightly regulated in cochlear outer hair cells (OHCs). It enters mainly via mechanotransducer (MT) channels and is extruded by the PMCA2 isoform of the plasma membrane calcium ATPase, mutations in which cause hearing loss. To assess how pu
Autor:
Jacqueline A. Tickle, David N. Furness
Publikováno v:
The Hearing Journal. 65:26-28
Autor:
Qingguo, Chen, Shanthini, Mahendrasingam, Jacqueline A, Tickle, Carole M, Hackney, David N, Furness, Robert, Fettiplace
Publikováno v:
The European journal of neuroscience. 36(3)
Calcium is tightly regulated in cochlear outer hair cells (OHCs). It enters mainly via mechanotransducer (MT) channels and is extruded by the plasma membrane calcium ATPase (PMCA)2 isoform of the PMCA, mutations in which cause hearing loss. To assess