Zobrazeno 1 - 10
of 398 559
pro vyhledávání: '"Jacqueline A"'
Autor:
Panayiotis Anastasiou, Christopher Moore, Sareena Rana, Mona Tomaschko, Claire E. Pillsbury, Andrea de Castro, Jesse Boumelha, Edurne Mugarza, Sophie de Carné Trécesson, Ania Mikolajczak, Cristina Blaj, Robert Goldstone, Jacqueline A. M. Smith, Elsa Quintana, Miriam Molina-Arcas, Julian Downward
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mutant selective drugs targeting the inactive, GDP-bound form of KRASG12C have been approved for use in lung cancer, but resistance develops rapidly. Here we use an inhibitor, (RMC-4998) that targets RASG12C in its active, GTP-bound form, to
Externí odkaz:
https://doaj.org/article/f04ce583c0fc4b438b6298469e1bd117
Autor:
Maria do Carmo Leal, Rosa Maria Soares Madeira Domingues, Thaís Cristina Oliveira Fonseca, Tatiana Henriques Leite, Ana Claudia Figueiró, Ana Paula Esteves Pereira, Mariza Miranda Theme-Filha, Bárbara Vasques da Silva Ayres, Oliver Scott, Rita de Cássia Sanchez, Paulo Borem, Maria Carolina de Maio Osti, Marcos Wengrover Rosa, Amanda S. Andrade, Fernando Maia Peixoto Filho, Marcos Nakamura-Pereira, Jacqueline Alves Torres
Publikováno v:
Reproductive Health, Vol 20, Iss S2, Pp 1-18 (2024)
Abstract Background Brazil is one of the countries with the highest rates of caesarean sections (CS), reaching almost 90% of births in the private sector. A quality improvement project called “Adequate Childbirth Project (PPA)” was conceived to r
Externí odkaz:
https://doaj.org/article/0914e978f03e4ede9426a1f2ce9fd43c
Autor:
Daniel Ramírez-García, Carlos A. Fermín-Martínez, Paulina Sánchez-Castro, Alejandra Núñez-Luna, Martín Roberto Basile-Alvarez, Luisa Fernández-Chirino, Arsenio Vargas-Vázquez, Juan Pablo Díaz-Sánchez, Ashuin Kammar-García, Paloma Almeda-Valdés, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre-Díaz, Jacqueline A. Seiglie, Neftali Eduardo Antonio-Villa, Omar Yaxmehen Bello-Chavolla
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Objective Evidence from low- and middle-income countries regarding the effect of smoking in people with diabetes is lacking. Here, we report the association of smoking with mortality in a large cohort of Mexican adults with diabetes. Methods
Externí odkaz:
https://doaj.org/article/49e3cc22b97847638a83a7343e2eb233
Autor:
Victor Becerril-Montekio, Pilar Torres-Pereda, Luis Alberto García-Bello, Jacqueline Alcalde-Rabanal
Publikováno v:
Revista Panamericana de Salud Pública, Vol 48, Iss 66, Pp 1-8 (2024)
Objectives. This paper describes and analyzes embedded implementation research and the empirical processes of planning for utilization, strategies to promote utilization and the sustainability of utilization of results from research led by decision-m
Externí odkaz:
https://doaj.org/article/c1c98a7773264834a5521c7d7f5b0618
Autor:
Conor J. O'Hanlon, Nick Holford, Brian J. Anderson, Mark Greaves, Lee Blackburn, Malcolm D. Tingle, Jacqueline A. Hannam
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1409-1421 (2024)
Abstract Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta‐lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported
Externí odkaz:
https://doaj.org/article/63766ef6483f42269ec7f7107a9503ee
Autor:
Christopher J. McLouth, Benton Maglinger, Jacqueline A. Frank, Hunter S. Hazelwood, Jordan P. Harp, Will Cranford, Shivani Pahwa, Lila Sheikhi, David Dornbos, Amanda L. Trout, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Introduction The Appalachia region of North America is known to have significant health disparities, specifically, worse risk factors and outcomes for stroke. Appalachians are more likely to have comorbidities related to stroke, such as diab
Externí odkaz:
https://doaj.org/article/235e0010af5e41dbb9753c84729af42d
Autor:
Yunwen Wang, Jacqueline Ann Bannon, Natalia Roszkowska, Essence Lynn Wilson, Stephen Bonett, Elizabeth Lazarus, Nadia Dowshen, Robin Stevens
Publikováno v:
BMC Digital Health, Vol 2, Iss 1, Pp 1-10 (2024)
Abstract Background Adolescents and young adults account for over 21% of new HIV infections in the U.S. with most new cases among young men. As an important information source for this group, social media can uniquely reveal the perspectives and comm
Externí odkaz:
https://doaj.org/article/93c36d3892f24080a205e084e2fa0f48
Autor:
Hidenori Kitai, Philip H. Choi, Yu C. Yang, Jacob A. Boyer, Adele Whaley, Priya Pancholi, Claire Thant, Jason Reiter, Kevin Chen, Vladimir Markov, Hirokazu Taniguchi, Rui Yamaguchi, Hiromichi Ebi, James Evans, Jingjing Jiang, Bianca Lee, David Wildes, Elisa de Stanchina, Jacqueline A. M. Smith, Mallika Singh, Neal Rosen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Current KRASG12C (OFF) inhibitors that target inactive GDP-bound KRASG12C cause responses in less than half of patients and these responses are not durable. A class of RASG12C (ON) inhibitors that targets active GTP-bound KRASG12C blocks ERK
Externí odkaz:
https://doaj.org/article/7ad6de68f66945a2a3cb9c50ceaaf9b5
Publikováno v:
Discover Materials, Vol 4, Iss 1, Pp 1-20 (2024)
Abstract Ammonium nitrate and aluminium (AN–Al) has been used as a typical homemade explosive (HME) by non-state actors since the turn of the century. Despite the regulation applied to ammonium nitrate above 16% nitrogen content and an aluminium pa
Externí odkaz:
https://doaj.org/article/9ab27e08b20f448bb67b400fac814c0b
Autor:
Megan E. Carey, To Nguyen Thi Nguyen, Do Hoang Nhu Tran, Zoe A. Dyson, Jacqueline A. Keane, Duy Pham Thanh, Elli Mylona, Satheesh Nair, Marie Chattaway, Stephen Baker
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Antimicrobial resistance (AMR) poses a serious threat to the clinical management of typhoid fever. AMR in Salmonella Typhi (S. Typhi) is commonly associated with the H58 lineage, a lineage that arose comparatively recently before becoming gl
Externí odkaz:
https://doaj.org/article/a46b108b6785473c9b00640c9a148816