Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jacqueline, Stöckli"'
Autor:
Alexis Diaz-Vegas, Kristen C. Cooke, Harry B. Cutler, Belinda Yau, Stewart W.C. Masson, Dylan Harney, Oliver K. Fuller, Meg Potter, Søren Madsen, Niamh R. Craw, Yiju Zhang, Cesar L. Moreno, Melkam A. Kebede, G. Gregory Neely, Jacqueline Stöckli, James G. Burchfield, David E. James
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101983- (2024)
Mitochondria facilitate thousands of biochemical reactions, covering a broad spectrum of anabolic and catabolic processes. Here we demonstrate that the adipocyte mitochondrial proteome is markedly altered across multiple models of insulin resistance
Externí odkaz:
https://doaj.org/article/d604aeab742c4b69b1c6b31c83faedfb
Autor:
Julian van Gerwen, Stewart WC Masson, Harry B Cutler, Alexis Diaz Vegas, Meg Potter, Jacqueline Stöckli, Søren Madsen, Marin E Nelson, Sean J Humphrey, David E James
Publikováno v:
eLife, Vol 12 (2024)
Metabolic disease is caused by a combination of genetic and environmental factors, yet few studies have examined how these factors influence signal transduction, a key mediator of metabolism. Using mass spectrometry-based phosphoproteomics, we quanti
Externí odkaz:
https://doaj.org/article/cb37267e2a92418cb41535f24ae78539
Autor:
Stewart WC Masson, Søren Madsen, Kristen C Cooke, Meg Potter, Alexis Diaz Vegas, Luke Carroll, Senthil Thillainadesan, Harry B Cutler, Ken R Walder, Gregory J Cooney, Grant Morahan, Jacqueline Stöckli, David E James
Publikováno v:
eLife, Vol 12 (2023)
Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. ‘Diversity Outbred in Australia (DOz)’ is a population of genetically unique mice with profou
Externí odkaz:
https://doaj.org/article/b8bfc06ac64146cfa4af3ab8d745020e
Autor:
Jacqueline Stöckli, Armella Zadoorian, Kristen C. Cooke, Vinita Deshpande, Belinda Yau, Gaia Herrmann, Melkam A. Kebede, Sean J. Humphrey, David E. James
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101219- (2021)
Externí odkaz:
https://doaj.org/article/c65a636f3f0148fa8389b7f22f55d0e5
Autor:
Deanne Francis, Shila Ghazanfar, Essi Havula, James R Krycer, Dario Strbenac, Alistair Senior, Annabel Y Minard, Thomas Geddes, Marin E Nelson, Fiona Weiss, Jacqueline Stöckli, Jean Y H Yang, David E James
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 10 (2021)
AbstractGenetic and environmental factors play a major role in metabolic health. However, they do not act in isolation, as a change in an environmental factor such as diet may exert different effects based on an individual’s genotype. Here, we soug
Externí odkaz:
https://doaj.org/article/22e39aa89e95440c9394f276fad33aca
Autor:
Jacqueline Stöckli, Armella Zadoorian, Kristen C. Cooke, Vinita Deshpande, Belinda Yau, Gaia Herrmann, Melkam A. Kebede, Sean J. Humphrey, David E. James
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 83-94 (2019)
Objective: Insulin suppresses adipose tissue lipolysis after a meal, playing a key role in metabolic homeostasis. This is mediated via the kinase Akt and its substrate phosphodiesterase 3B (PDE3B). Once phosphorylated and activated, PDE3B hydrolyses
Externí odkaz:
https://doaj.org/article/89f28921dd844bddadf5ec401d3824cf
Autor:
Stewart W.C. Masson, Søren Madsen, Kristen C. Cooke, Meg Potter, Alexis Diaz-Vegas, Luke Carroll, Senthil Thillainadesan, Ken Walder, Gregory J. Cooney, Grant Morahan, Jacqueline Stöckli, David E. James
Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. “Diversity Outbred in Australia (DOz)” is a population of genetically unique mice with profou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82c36b41510e6d69af78e8f21d1de24
https://doi.org/10.7554/elife.86961
https://doi.org/10.7554/elife.86961
Autor:
Annabel Y. Minard, Shi-Xiong Tan, Pengyi Yang, Daniel J. Fazakerley, Westa Domanova, Benjamin L. Parker, Sean J. Humphrey, Raja Jothi, Jacqueline Stöckli, David E. James
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 29-36 (2016)
FGF21 improves the metabolic profile of obese animals through its actions on adipocytes. To elucidate the signaling network responsible for mediating these effects, we quantified dynamic changes in the adipocyte phosphoproteome following acute exposu
Externí odkaz:
https://doaj.org/article/f0471ecc6c7a41aeb1fe44641cbc6241
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db603490832812e2263955b9cf1ba41b
https://doi.org/10.1016/b978-0-12-821618-7.00025-0
https://doi.org/10.1016/b978-0-12-821618-7.00025-0
Publikováno v:
Nature Reviews Molecular Cell Biology. 22:751-771
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in tissues — prominently in muscle, fat and liver — is one of the earliest manifestations of a constellation of human diseases that includes type 2 diabetes