Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jacqueline, Lovett"'
Autor:
Ruin Moaddel, Panos Zanos, Cristan A. Farmer, Bashkim Kadriu, Patrick J. Morris, Jacqueline Lovett, Elia E. Acevedo-Diaz, Grace W. Cavanaugh, Peixiong Yuan, Mani Yavi, Craig J. Thomas, Lawrence T. Park, Luigi Ferrucci, Todd D. Gould, Carlos A. Zarate
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Subanesthetic-dose racemic (R,S)-ketamine (ketamine) produces rapid, robust, and sustained antidepressant effects in major depressive disorder (MDD) and bipolar disorder (BD) and has also been shown to effectively treat neuropathic pain, com
Externí odkaz:
https://doaj.org/article/a822b41b1e6245a389bcef25692869af
Autor:
Andrew McGarry, John Gaughan, Cory Hackmyer, Jacqueline Lovett, Mohammed Khadeer, Hamza Shaikh, Basant Pradhan, Thomas N. Ferraro, Irving W. Wainer, Ruin Moaddel
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Huntington’s Disease (HD) is a progressive, fatal neurodegenerative condition. While generally considered for its devastating neurological phenotype, disturbances in other organ systems and metabolic pathways outside the brain have attract
Externí odkaz:
https://doaj.org/article/5ae9c5e256a348519a3dd38699b08cf5
Autor:
Reyhan Westbrook, Tae Chung, Jacqueline Lovett, Chris Ward, Humberto Joca, Huanle Yang, Mohammed Khadeer, Jing Tian, Qian-Li Xue, Anne Le, Luigi Ferrucci, Ruin Moaddel, Rafa de Cabo, Ahmet Hoke, Jeremy Walston, Peter M. Abadir
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood. A mouse model of chronic inflammation showed reduced motor function and partial den
Externí odkaz:
https://doaj.org/article/54cb1923abda4714a2deb802d930ca63
Autor:
Andrew McGarry, John Gaughan, Cory Hackmyer, Jacqueline Lovett, Mohammed Khadeer, Hamza Shaikh, Basant Pradhan, Thomas N. Ferraro, Irving W. Wainer, Ruin Moaddel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-2 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/fb490b90957b4237968ae1b3decbb22d
Autor:
Polymnia Georgiou, Panos Zanos, Ta-Chung M. Mou, Xiaoxian An, Danielle M. Gerhard, Dilyan I. Dryanovski, Liam E. Potter, Jaclyn N. Highland, Carleigh E. Jenne, Brent W. Stewart, Katherine J. Pultorak, Peixiong Yuan, Chris F. Powels, Jacqueline Lovett, Edna F. R. Pereira, Sarah M. Clark, Leonardo H. Tonelli, Ruin Moaddel, Carlos A. Zarate, Ronald S. Duman, Scott M. Thompson, Todd D. Gould
Publikováno v:
Nat Neurosci
We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its bioactive metabolite (2R,6R)-hydroxynorketamine. Mice showed aversion to the scent of male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2785218ca391a1003e91994de1564c3
https://doi.org/10.1038/s41593-022-01146-x
https://doi.org/10.1038/s41593-022-01146-x
Autor:
Jaclyn N Highland, Cristan A Farmer, Panos Zanos, Jacqueline Lovett, Carlos A Zarate, Ruin Moaddel, Todd D Gould
Publikováno v:
J Psychopharmacol
Background: Ketamine is rapidly metabolized to norketamine and hydroxynorketamine (HNK) metabolites. In female mice, when compared to males, higher levels of ( 2R,6R;2S,6S)-HNK have been observed following ketamine treatment, and higher levels of ( 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0089288bb9434a390154bfbcd5ce9530
https://doi.org/10.1177/02698811211064922
https://doi.org/10.1177/02698811211064922
Autor:
Michael Vreones, Maja Mustapic, Ruin Moaddel, Krishna A. Pucha, Jacqueline Lovett, Douglas R. Seals, Dimitrios Kapogiannis, Christopher R. Martens
Publikováno v:
Aging cellREFERENCES.
Declining nicotinamide adenine dinucleotide (NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac39196b572919cbf32b1c247b21314c
https://pubmed.ncbi.nlm.nih.gov/36515353
https://pubmed.ncbi.nlm.nih.gov/36515353
Autor:
Jacqueline Lovett, Ruin Moaddel, Irving W. Wainer, William Denk, Clinton G. Lauritsen, Eric S. Schwenk, Marc C. Torjman, Daniel Katz, Stephen D. Silberstein
Publikováno v:
J Clin Pharmacol
Patients with refractory chronic migraine have substantial disability and have failed many acute and preventive medications. When aggressive intravenous therapy is indicated, both lidocaine and (R,S)-ketamine infusions have been used successfully to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7c988ae81be8bddc89ed6850a2471f
https://doi.org/10.1002/jcph.1920
https://doi.org/10.1002/jcph.1920
Autor:
J Eduardo Rico, Sina Saed Samii, Alice T Mathews, Jacqueline Lovett, Norman J Haughey, Joseph W McFadden
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176787 (2017)
Reduced insulin action develops naturally during the peripartum to ensure maternal nutrient delivery to the fetus and neonate. However, increased insulin resistance can facilitate excessive lipolysis which in turn promotes metabolic disease in overwe
Externí odkaz:
https://doaj.org/article/042cf984492b477cbdd0bd73f88fa91a
Autor:
Jomy M. George, Carlos A. Zarate, Jacqueline Lovett, Todd D. Gould, Cristan Farmer, Bashkim Kadriu, Allison C. Nugent, Lawrence Park, Ruin Moaddel, Lilian W Adeojo, Peixiong Yuan, Jessica R. Gilbert
Publikováno v:
Neuropsychopharmacology. 45:1398-1404
A single, subanesthetic dose of (R,S)-ketamine (ketamine) exerts rapid and robust antidepressant effects. Several groups previously reported that (2S,6S;2R,6R)-hydroxynorketamine (HNK) had antidepressant effects in rodents, and that (2R,6R)-HNK incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17407d22744181aca6735638b7c83ee4
https://doi.org/10.1038/s41386-020-0663-6
https://doi.org/10.1038/s41386-020-0663-6