Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Jacqueline, Boultwood"'
Autor:
Sila Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz, I Richard Thompson, Seyed R Jalili, Deniz E Kaya, Alfredo Iacoangeli, Andrea Pellagatti, Jacqueline Boultwood, Giorgio Napolitani, Ghulam J Mufti, Mohammad M Karimi
Publikováno v:
eLife, Vol 13 (2024)
Mutational profiles of myelodysplastic syndromes (MDS) have established that a relatively small number of genetic aberrations, including SF3B1 and SRSF2 spliceosome mutations, lead to specific phenotypes and prognostic subgrouping. We performed a mul
Externí odkaz:
https://doaj.org/article/3ee4a561cd2144888814648747b54fd4
Autor:
Fabio Efficace, Rena Buckstein, Gregory A. Abel, Johannes M. Giesinger, Pierre Fenaux, Jan Philipp Bewersdorf, Andrew M. Brunner, Rafael Bejar, Uma Borate, Amy E. DeZern, Peter Greenberg, Gail J. Roboz, Michael R. Savona, Francesco Sparano, Jacqueline Boultwood, Rami Komrokji, David A. Sallman, Zhuoer Xie, Guillermo Sanz, Hetty E. Carraway, Justin Taylor, Stephen D. Nimer, Matteo Giovanni Della Porta, Valeria Santini, Maximilian Stahl, Uwe Platzbecker, Mikkael A. Sekeres, Amer M. Zeidan
Publikováno v:
HemaSphere, Vol 8, Iss 5, Pp n/a-n/a (2024)
Abstract Notable treatment advances have been made in recent years for patients with myelodysplastic syndromes/neoplasms (MDS), and several new drugs are under development. For example, the emerging availability of oral MDS therapies holds the promis
Externí odkaz:
https://doaj.org/article/cf17fd5c0de047b1a6c103df622ef528
Autor:
Sara Mongiorgi, Alessia De Stefano, Stefano Ratti, Valentina Indio, Annalisa Astolfi, Irene Casalin, Andrea Pellagatti, Stefania Paolini, Sarah Parisi, Michele Cavo, Andrea Pession, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Jacqueline Boultwood, Carlo Finelli, Lucio Cocco, Matilde Y. Follo
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background miRNAs are small non-coding RNAs that regulate gene expression and are linked to cancer development and progression. miRNA profiles are currently studied as new prognostic factors or therapeutic perspectives. Among hematological c
Externí odkaz:
https://doaj.org/article/c109ec95839b4454ba98608885f40f32
Autor:
Nora E. Rahmani, Nandini Ramachandra, Srabani Sahu, Nadege Gitego, Andrea Lopez, Kith Pradhan, Tushar D. Bhagat, Shanisha Gordon-Mitchell, Bianca Rivera Pena, Mohammad Kazemi, Keshav Rao, Orsi Giricz, Shahina Bano Maqbool, Raul Olea, Yongmei Zhao, Jinghang Zhang, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Juseong Lee, Tianyu Sun, Ulrich Steidl, Aditi Shastri, Daichi Inoue, Omar Abdel-Wahab, Andrea Pellagatti, Evripidis Gavathiotis, Jacqueline Boultwood, Amit Verma
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 9, Pp 1-8 (2021)
Abstract The BCL2-inhibitor, Venetoclax (VEN), has shown significant anti-leukemic efficacy in combination with the DNMT-inhibitor, Azacytidine (AZA). To explore the mechanisms underlying the selective sensitivity of mutant leukemia cells to VEN and
Externí odkaz:
https://doaj.org/article/ebcdc68081b74bb08aadabec941cc80f
Autor:
Gaurav S Choudhary, Andrea Pellagatti, Bogos Agianian, Molly A Smith, Tushar D Bhagat, Shanisha Gordon-Mitchell, Srabani Sahu, Sanjay Pandey, Nishi Shah, Srinivas Aluri, Ritesh Aggarwal, Sarah Aminov, Leya Schwartz, Violetta Steeples, Robert N Booher, Murali Ramachandra, Maria Samson, Milagros Carbajal, Kith Pradhan, Teresa V Bowman, Manoj M Pillai, Britta Will, Amittha Wickrema, Aditi Shastri, Robert K Bradley, Robert E Martell, Ulrich G Steidl, Evripidis Gavathiotis, Jacqueline Boultwood, Daniel T Starczynowski, Amit Verma
Publikováno v:
eLife, Vol 11 (2022)
Background: Mutations in the SF3B1 splicing factor are commonly seen in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet the specific oncogenic pathways activated by mis-splicing have not been fully elucidated. Inflammatory immun
Externí odkaz:
https://doaj.org/article/530c5c84de264ae68b3135c39fce561b
Autor:
Vera Adema, Laura Palomo, Wencke Walter, Mar Mallo, Stephan Hutter, Thomas La Framboise, Leonor Arenillas, Manja Meggendorfer, Tomas Radivoyevitch, Blanca Xicoy, Andrea Pellagatti, Claudia Haferlach, Jacqueline Boultwood, Wolfgang Kern, Valeria Visconte, Mikkael Sekeres, John Barnard, Torsten Haferlach, Francesc Solé, Jaroslaw P. Maciejewski
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104059- (2022)
Summary: Background: Haploinsufficiency (HI) resulting from deletion of the long arm of chromosome 5 [del(5q)] and the accompanied loss of heterozygosity are likely key pathogenic factors in del(5q) myeloid neoplasia (MN) although the consequences of
Externí odkaz:
https://doaj.org/article/06bea150e50f4e07b9fd3c89f1ebed7a
Autor:
Kathy L. McGraw, Chia-Ho Cheng, Y. Ann Chen, Hsin-An Hou, Björn Nilsson, Giulio Genovese, Thomas Cluzeau, Andrea Pellagatti, Bartlomiej P. Przychodzen, Mar Mallo, Leonor Arenillas, Azim Mohamedali, Lionel Adès, David A. Sallman, Eric Padron, Lubomir Sokol, Chimene Moreilhon, Sophie Raynaud, Hwei-Fang Tien, Jacqueline Boultwood, Benjamin L. Ebert, Francesc Sole, Pierre Fenaux, Ghulam J. Mufti, Jaroslaw P. Maciejewski, Peter A. Kanetsky, Alan F. List
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3579-3589 (2019)
Abstract: Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies. Known predisposing factors to adult MDS include rare germline mutations, cytotoxic therapy, age-related clonal hematopoiesis, and autoimmune or chronic inflammatory d
Externí odkaz:
https://doaj.org/article/cf1ad2d32c354d1dad1743567cc1316e
Autor:
Marco L. Hennrich, Natalie Romanov, Patrick Horn, Samira Jaeger, Volker Eckstein, Violetta Steeples, Fei Ye, Ximing Ding, Laura Poisa-Beiro, Mang Ching Lai, Benjamin Lang, Jacqueline Boultwood, Thomas Luft, Judith B. Zaugg, Andrea Pellagatti, Peer Bork, Patrick Aloy, Anne-Claude Gavin, Anthony D. Ho
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced b
Externí odkaz:
https://doaj.org/article/86524845718d4cb59745f4c377ff0da5
Publikováno v:
HemaSphere, Vol 3, Pp 132-134 (2019)
Externí odkaz:
https://doaj.org/article/37ca55a601c142398485d427854aeac9
Autor:
Amer M. Zeidan, Jan Philipp Bewersdorf, Rena Buckstein, Mikkael A. Sekeres, David P. Steensma, Uwe Platzbecker, Sanam Loghavi, Jacqueline Boultwood, Rafael Bejar, John M. Bennett, Uma Borate, Andrew M. Brunner, Hetty Carraway, Jane E. Churpek, Naval G. Daver, Matteo Della Porta, Amy E. DeZern, Fabio Efficace, Pierre Fenaux, Maria E. Figueroa, Peter Greenberg, Elizabeth A. Griffiths, Stephanie Halene, Robert P. Hasserjian, Christopher S. Hourigan, Nina Kim, Tae Kon Kim, Rami S. Komrokji, Vijay Kutchroo, Alan F. List, Richard F. Little, Ravi Majeti, Aziz Nazha, Stephen D. Nimer, Olatoyosi Odenike, Eric Padron, Mrinal M. Patnaik, Gail J. Roboz, David A. Sallman, Guillermo Sanz, Maximilian Stahl, Daniel T. Starczynowski, Justin Taylor, Zhuoer Xie, Mina Xu, Michael R. Savona, Andrew H. Wei, Omar Abdel-Wahab, Valeria Santini
Publikováno v:
Leukemia. 36:2939-2946