Single-molecule digital sizing of proteins in solution.

Autor: Krainer G; Institute of Molecular Biosciences (IMB), University of Graz, Humboldtstraße 50, 8010, Graz, Austria. georg.krainer@uni-graz.at.; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. georg.krainer@uni-graz.at., Jacquat RPB; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Schneider MM; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Department of Cellular Biochemistry, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany., Welsh TJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Fan J; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Peter QAE; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Andrzejewska EA; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Šneiderienė G; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Czekalska MA; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Ausserwoeger H; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Chai L; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Arter WE; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Saar KL; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Herling TW; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Franzmann TM; Center for Molecular and Cellular Bioengineering, Biotechnology Center, Technische Universität Dresden, Tatzberg 47/49, 01307, Dresden, Germany., Kosmoliaptsis V; Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.; NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.; NIHR Cambridge Biomedical Research Centre, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK., Alberti S; Center for Molecular and Cellular Bioengineering, Biotechnology Center, Technische Universität Dresden, Tatzberg 47/49, 01307, Dresden, Germany., Hartl FU; Department of Cellular Biochemistry, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.; Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377, Munich, Germany., Lee SF; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Knowles TPJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. tpjk2@cam.ac.uk.; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Ave, Cambridge, CB3 0HE, UK. tpjk2@cam.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 04; Vol. 15 (1), pp. 7740. Date of Electronic Publication: 2024 Sep 04.

RNA modulates hnRNPA1A amyloid formation mediated by biomolecular condensates.

Autor: Morelli C; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland., Faltova L; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland., Capasso Palmiero U; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland., Makasewicz K; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland., Papp M; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland., Jacquat RPB; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland., Pinotsi D; Scientific Center for Optical and Electron Microscopy, ETH Zurich, Zürich, Switzerland., Arosio P; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland. paolo.arosio@chem.ethz.ch.

Publikováno v: Nature chemistry [Nat Chem] 2024 Jul; Vol. 16 (7), pp. 1052-1061. Date of Electronic Publication: 2024 Mar 12.

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.

Autor: Emmenegger M; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., De Cecco E; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Lamparter D; Health2030 Genome Center, 9 Chemin des Mines, 1202 Geneva, Switzerland., Jacquat RPB; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK., Riou J; Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland., Menges D; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Ballouz T; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Ebner D; Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, England., Schneider MM; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Morales IC; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Doğançay B; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Guo J; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Wiedmer A; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Domange J; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Imeri M; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Moos R; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Zografou C; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Batkitar L; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Madrigal L; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Schneider D; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Trevisan C; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Gonzalez-Guerra A; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Carrella A; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Dubach IL; Division of Internal Medicine, University Hospital Zurich, 8091 Zurich, Switzerland., Xu CK; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Meisl G; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Kosmoliaptsis V; Department of Surgery, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK.; NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK., Malinauskas T; Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK., Burgess-Brown N; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK., Owens R; Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.; The Rosalind Franklin Institute, Harwell Campus, Oxford OX11 0FA, UK., Hatch S; Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, England., Mongkolsapaya J; Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Screaton GR; Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Schubert K; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Huck JD; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Liu F; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Pojer F; Protein Production and Structure Core Facility, EPFL SV PTECH PTPSP, 1015 Lausanne, Switzerland., Lau K; Protein Production and Structure Core Facility, EPFL SV PTECH PTPSP, 1015 Lausanne, Switzerland., Hacker D; Protein Production and Structure Core Facility, EPFL SV PTECH PTPSP, 1015 Lausanne, Switzerland., Probst-Müller E; Department of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland., Cervia C; Department of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland., Nilsson J; Department of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland., Boyman O; Department of Immunology, University Hospital Zurich, 8091 Zurich, Switzerland.; Faculty of Medicine, University of Zurich, 8006 Zurich, Switzerland., Saleh L; Institute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland., Spanaus K; Institute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland., von Eckardstein A; Institute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland., Schaer DJ; Division of Internal Medicine, University Hospital Zurich, 8091 Zurich, Switzerland., Ban N; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland., Tsai CJ; Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland., Marino J; Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland., Schertler GFX; Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland.; Department of Biology, ETH Zürich, 8093 Zürich, Switzerland., Ebert N; Institute of Virology and Immunology, 3012 Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Thiel V; Institute of Virology and Immunology, 3012 Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Gottschalk J; Regional Blood Transfusion Service Zurich, Swiss Red Cross, 8952 Schlieren, Switzerland., Frey BM; Regional Blood Transfusion Service Zurich, Swiss Red Cross, 8952 Schlieren, Switzerland., Reimann RR; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Hornemann S; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland., Ring AM; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Knowles TPJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK., Puhan MA; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zürich, Switzerland., Althaus CL; Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland., Xenarios I; Health2030 Genome Center, 9 Chemin des Mines, 1202 Geneva, Switzerland.; Agora Center, University of Lausanne, 25 Avenue du Bugnon, 1005 Lausanne, Switzerland., Stuart DI; Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK., Aguzzi A; Institute of Neuropathology, University of Zurich, 8091 Zurich, Switzerland.

Publikováno v: IScience [iScience] 2023 Feb 17; Vol. 26 (2), pp. 105928. Date of Electronic Publication: 2023 Jan 04.

Microscale Diffusiophoresis of Proteins.

Autor: Peter QAE; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EWCambridge, U.K., Jacquat RPB; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, CB3 0HECambridge, U.K., Herling TW; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EWCambridge, U.K., Challa PK; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EWCambridge, U.K., Kartanas T; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EWCambridge, U.K., Knowles TPJ; Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EWCambridge, U.K.

Publikováno v: The journal of physical chemistry. B [J Phys Chem B] 2022 Nov 10; Vol. 126 (44), pp. 8913-8920. Date of Electronic Publication: 2022 Oct 28.