Výsledky vyhledávání - "Jacopo, Mariotti"

Akademický článek

Persistence of KIRneg NK cells after haploidentical hematopoietic stem cell transplantation protects from human cytomegalovirus infection/reactivation

Autor: Clara Di Vito, Nicolò Coianiz, Michela Calvi, Sara Terzoli, Elisa Zaghi, Simone Puccio, Alessandro Frigo, Jacopo Mariotti, Chiara De Philippis, Daniele Mannina, Barbara Sarina, Rossana Mineri, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Luca Castagna, Stefania Bramanti, Armando Santoro, Domenico Mavilio

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

Haploidentical hematopoietic stem cell transplantation (h-HSCT) is a therapeutic option to cure patients affected by hematologic malignancies. The kinetics and the quality of immune-reconstitution (IR) impact the clinical outcome of h-HSCT and limit

Externí odkaz: https://doaj.org/article/ff1e1518e9bd4fbda530dbd55204e118

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Akademický článek

Outcome of High-Dose Chemotherapy Followed by Autologous Stem Cell Transplantation in Relapsed/Refractory Hodgkin Lymphoma after Different Numbers of Salvage Regimens

Autor: Jacopo Mariotti, Francesca Ricci, Laura Giordano, Daniela Taurino, Barbara Sarina, Chiara De Philippis, Daniele Mannina, Carmelo Carlo-Stella, Stefania Bramanti, Armando Santoro

Publikováno v: Cells, Vol 13, Iss 2, p 118 (2024)

The introduction of novel drugs (PD-1 inhibitors and/or brentuximab vedotin) into salvage regimens has improved the response rate and the outcome of patients with relapsed/refractory Hodgkin lymphoma. However, the impact of new drugs on the outcome h

Externí odkaz: https://doaj.org/article/f2ce499b378d40158dae1debf3e814fc

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Akademický článek

Pretransplant active disease status and HLA class II mismatching are associated with increased incidence and severity of cytokine release syndrome after haploidentical transplantation with posttransplant cyclophosphamide

Autor: Jacopo Mariotti, Daniela Taurino, Fabrizio Marino, Stefania Bramanti, Barbara Sarina, Lucio Morabito, Chiara De Philippis, Clara Di Vito, Domenico Mavilio, Carmelo Carlo‐Stella, Matteo Della Porta, Armando Santoro, Luca Castagna

Publikováno v: Cancer Medicine, Vol 9, Iss 1, Pp 52-61 (2020)

Abstract Cytokine release syndrome (CRS) represents a life‐threatening side effect after haploidentical stem cell transplantation (Haplo‐SCT) with posttransplant cyclophosphamide (PT‐Cy). Factors predictive of CRS development is still a matter

Externí odkaz: https://doaj.org/article/99e62eeddf6c46e0b49324a1098a5134

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Akademický článek

Extracellular Vesicles as Biomarkers of Acute Graft-vs.-Host Disease After Haploidentical Stem Cell Transplantation and Post-Transplant Cyclophosphamide

Autor: Giuseppe Lia, Clara Di Vito, Stefania Bruno, Marta Tapparo, Lucia Brunello, Armando Santoro, Jacopo Mariotti, Stefania Bramanti, Elisa Zaghi, Michela Calvi, Lorenzo Comba, Martina Fascì, Luisa Giaccone, Giovanni Camussi, Eileen M. Boyle, Luca Castagna, Andrea Evangelista, Domenico Mavilio, Benedetto Bruno

Publikováno v: Frontiers in Immunology, Vol 12 (2022)

Even with high-dose post-transplant cyclophosphamide (PT-Cy) which was initially introduced for graft-versus-host disease (GvHD) prevention in the setting of HLA-haploidentical transplantation, both acute and chronic GvHDs remain a major clinical cha

Externí odkaz: https://doaj.org/article/4d2407bf0bf8413989b037ba34433948

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Akademický článek

Single-cell profiling identifies impaired adaptive NK cells expanded after HCMV reactivation in haploidentical HSCT

Publikováno v: JCI Insight, Vol 6, Iss 12 (2021)

Haploidentical hematopoietic stem cell transplantation (h-HSCT) represents an efficient curative approach for patients affected by hematologic malignancies in which the reduced intensity conditioning induces a state of immunologic tolerance between d

Externí odkaz: https://doaj.org/article/0a56f5f4bf464fbf844eb17c2cc2c103

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Supplementary Figures S1-6 from Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects

Autor: Jacopo Mariotti, Paolo Corradini, Anisa Bermema, Davide Confalonieri, Camilla Recordati, Antonio Vendramin, Silvia Gimondi, Cristiana Carniti

Supplementary Figures S1-6. Figure S1: Histological staging criteria for acute GvHD Figure S2: Ruxolitinib does not impair post-transplant donor myeloid reconstitution and full donor chimerism. Figure S3: GVT effect against myeloid leukemia RMB-1 cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eda3ce0e9027b4cfc75a265b96217bd
https://doi.org/10.1158/1078-0432.22457555

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Data from Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects

Autor: Jacopo Mariotti, Paolo Corradini, Anisa Bermema, Davide Confalonieri, Camilla Recordati, Antonio Vendramin, Silvia Gimondi, Cristiana Carniti

Purpose: Immune-mediated graft-versus-tumor (GVT) effects can occur after allogeneic hematopoietic stem cell transplantation (HSCT), but GVT is tightly linked to its main complication, graft-versus-host disease (GVHD). Strategies aimed at modulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b3eee6f6de4d21647789f041285498
https://doi.org/10.1158/1078-0432.c.6523616

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