Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jacobus J. Bergh"'
Publikováno v:
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie. 36
Parkinson se siekte is ’n komplekse neurodegeneratiewe siektetoestand. Huidige behandeling van die siekte is slegs op simptomatiese verligting gemik, sonder dat die siekteverloop vertraag of gestop word. Sedert die ontdekking dat adenosien A 1 - en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77c7e4ae44beb9efb982ca5820435c77
https://doi.org/10.4102/satnt.v36i1.1381
https://doi.org/10.4102/satnt.v36i1.1381
Publikováno v:
South African Journal of Science and Technology, Vol 36, Iss 1 (2017)
Parkinson se siekte is ’n komplekse neurodegeneratiewe siektetoestand. Huidige behandeling van dié siekte is slegs op simptomatiese verligting gemik, sonder dat die siekteverloop vertraag of gestop word. Sedert die ontdekking dat adenosien A1- en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::457d0e4523ea8ca8365662e02922c3ed
http://www.satnt.ac.za/index.php/satnt/article/view/1381/1048
http://www.satnt.ac.za/index.php/satnt/article/view/1381/1048
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:261-274
Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform with (E)-5-styrylisatin bein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ba0b0577bc4b07b0d6181692332655
https://doi.org/10.1016/j.bmc.2010.11.028
https://doi.org/10.1016/j.bmc.2010.11.028
Autor:
Elizna M. Van der Walt, Erika M. Milczek, Dale E. Edmondson, Neal Castagnoli, Jacobus J. Bergh, Jacobus P. Petzer, Sarel F. Malan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2509-2513
Previous studies have shown that (E)-8-(3-chlorostyryl)caffeine (CSC) is a specific reversible inhibitor of human monoamine oxidase B (MAO-B) and does not bind to human MAO-A. Since the small molecule isatin is a natural reversible inhibitor of both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24dda5b62f50197cf3e81abda3fbeaca
https://doi.org/10.1016/j.bmcl.2009.03.030
https://doi.org/10.1016/j.bmcl.2009.03.030
Publikováno v:
Food and Chemical Toxicology. 46:3186-3192
We investigated the protective effect of pravastatin, simvastatin and atorvastatin on striatal DNA damage as a potential method to conserve and protect the nigrostriatal neurons. C57Bl/J6 mice were treated with combinations of a statin and the neurot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea06855a9d4ca1728fe23e0c49f5f5cd
https://doi.org/10.1016/j.fct.2008.07.006
https://doi.org/10.1016/j.fct.2008.07.006
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:3512-3521
The adenosine A 2A receptor has emerged as a possible target for the treatment of Parkinson’s disease (PD). Evidence suggests that antagonism of the A 2A receptor not only improves the symptoms of the disease but may also protect against the underl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51e41f573f07fb3e09dd508b820fdca
https://doi.org/10.1016/j.bmc.2006.01.011
https://doi.org/10.1016/j.bmc.2006.01.011
Publikováno v:
Life Sciences. 75:1243-1253
Acetyl-L-carnitine (ALCAR) is intimately involved in the transport of long chain fatty acids across the inner mitochondrial membrane during oxidative phosphorylation. ALCAR also has been reported to attenuate the occurrence of parkinsonian symptoms a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e76eb518fc5e703b54c5388a02efa4
https://doi.org/10.1016/j.lfs.2004.03.007
https://doi.org/10.1016/j.lfs.2004.03.007
Publikováno v:
Journal of Pharmaceutical Sciences. 92:2519-2533
In this study the single-crystal X-ray structure of the solvated species (nifedipine)2. 1,4-dioxane is reported for the first time. Included solvent molecules are located in isolated cavities in the crystal, yielding a very stable solvate. Desolvatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4ff1a30332568febdccfb84fb293b5
https://doi.org/10.1002/jps.10506
https://doi.org/10.1002/jps.10506
Autor:
Gisella Terre’Blanche, Sarel J. Robinson, Anél Petzer, Jacobus P. Petzer, Anna C.U. Lourens, Mietha M. Van der Walt, Jacobus J. Bergh
In this study thirteen 2-aminopyrimidine derivatives were synthesised and screened as potential antagonists of adenosine A1 and A2A receptors in order to further investigate the structure activity relationships of this class of compounds. 4-(5-Methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09fb93ed779334e86e76a6777a84c6c
https://www.sciencedirect.com/science/article/pii/S0223523415302798
https://www.sciencedirect.com/science/article/pii/S0223523415302798
Autor:
Lodewyk J. Mienie, Jeffrey R. Bloomquist, Stefanus J. Steyn, Neal Castagnoli, Jacobus J. Bergh, Cornelis J. Van der Schyf
Publikováno v:
Life Sciences. 65:535-542
We report the presence of p -fluorophenylglycine ( p -FPG) in the urine of six baboons treated with HPTP, the tetrahydropyridine dehydration product of haloperidol (HP). Oxidative N-dealkylation, the major metabolic pathway of HP, gives rise to 3-(4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87d61641486cf21a797dc737371a7da
https://doi.org/10.1016/s0024-3205(99)00274-x
https://doi.org/10.1016/s0024-3205(99)00274-x