Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Jacobson MP"'
Autor:
Jacobson, Matthew, Jameson, JB, Kantz, A, Schultz, L, Kalyanaraman, C, Jacobson, MP, Maloney, DJ, Jadhav, A, Simeonov, A, Holman, TR
Publikováno v:
Jacobson, Matthew; Jameson, JB; Kantz, A; Schultz, L; Kalyanaraman, C; Jacobson, MP; et al.(2014). A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8cq899v6
Lipoxygenase (LOX) enzymes catalyze the hydroperoxidation of arachidonic acid and other polyunsaturated fatty acids to hydroxyeicosatetraenoic acids with varying positional specificity to yield important biological signaling molecules. Human epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::a264111537d57ad2729a066811c6a529
http://www.escholarship.org/uc/item/8cq899v6
http://www.escholarship.org/uc/item/8cq899v6
Autor:
Babbitt, Patricia, Sali, Andrej, Jacobson, Matthew, Shoichet, Brian, Dong, GQ, Calhoun, S, Fan, H, Kalyanaraman, C, Branch, MC, Mashiyama, ST, London, N, Jacobson, MP, Babbitt, PC, Shoichet, BK
Publikováno v:
Babbitt, Patricia; Sali, Andrej; Jacobson, Matthew; Shoichet, Brian; Dong, GQ; Calhoun, S; et al.(2014). Prediction of substrates for glutathione transferases by covalent docking. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6p17g9gg
Enzymes in the glutathione transferase (GST) superfamily catalyze the conjugation of glutathione (GSH) to electrophilic substrates. As a consequence they are involved in a number of key biological processes, including protection of cells against chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::460ebc32804e7e9268f20463a6a5f0d2
http://www.escholarship.org/uc/item/6p17g9gg
http://www.escholarship.org/uc/item/6p17g9gg
Publikováno v:
Jacobson, Matthew; Lexa, KW; Dolghih, E; & Jacobson, MP. (2014). A structure-based model for predicting serum albumin binding. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4wq912z4
One of the many factors involved in determining the distribution and metabolism of a compound is the strength of its binding to human serum albumin. While experimental and QSAR approaches for determining binding to albumin exist, various factors limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::a509b7c309ccea14887c74f5ff934573
http://www.escholarship.org/uc/item/4wq912z4
http://www.escholarship.org/uc/item/4wq912z4
Autor:
Jacobson, Matthew, Kumar, R, Zhao, S, Vetting, MW, Wood, BM, Sakai, A, Cho, K, Solbiati, J, Almo, SC, Sweedler, JV, Jacobson, MP
Publikováno v:
Jacobson, Matthew; Kumar, R; Zhao, S; Vetting, MW; Wood, BM; Sakai, A; et al.(2014). Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2hc8q2cs
Through the use of genetic, enzymatic, metabolomic, and structural analyses, we have discovered the catabolic pathway for proline betaine, an osmoprotectant, in Paracoccus denitrificans and Rhodobacter sphaeroides. Genetic and enzymatic analyses show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::fdfea8da5488c26529eb7ffeb80d93ba
http://www.escholarship.org/uc/item/2hc8q2cs
http://www.escholarship.org/uc/item/2hc8q2cs
Autor:
Babbitt, Patricia, Jacobson, Matthew, Tian, BX, Wallrapp, FH, Holiday, GL, Chow, JY, Babbitt, PC, Poulter, CD, Jacobson, MP
Publikováno v:
Babbitt, Patricia; Jacobson, Matthew; Tian, BX; Wallrapp, FH; Holiday, GL; Chow, JY; et al.(2014). Predicting the Functions and Specificity of Triterpenoid Synthases: A Mechanism-Based Multi-intermediate Docking Approach. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6t1708zr
© 2014 Tian et al.Terpenoid synthases construct the carbon skeletons of tens of thousands of natural products. To predict functions and specificity of triterpenoid synthases, a mechanism-based, multi-intermediate docking approach is proposed. In add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::56cbed558e8aac4fb1802e60d6ddc8f7
http://www.escholarship.org/uc/item/6t1708zr
http://www.escholarship.org/uc/item/6t1708zr
Publikováno v:
Jacobson, Matthew; Agard, David; Peng, LX; Hsu, MT; Bonomi, M; & Jacobson, MP. (2014). The Free Energy Profile of Tubulin Straight-Bent Conformational Changes, with Implications for Microtubule Assembly and Drug Discovery. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/79z893gg
αβ-tubulin dimers need to convert between a 'bent' conformation observed for free dimers in solution and a 'straight' conformation required for incorporation into the microtubule lattice. Here, we investigate the free energy landscape of αβ-tubul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::f05f0a006f3c18a007284890319d8e11
http://www.escholarship.org/uc/item/79z893gg
http://www.escholarship.org/uc/item/79z893gg
Publikováno v:
Jacobson, Matthew; Hasnain, S; McClendon, CL; Hsu, MT; Jacobson, MP; & Bandyopadhyay, P. (2014). A new coarse-grained model for E. coli cytoplasm: Accurate calculation of the diffusion coefficient of proteins and observation of anomalous diffusion. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6pr6r8xc
A new coarse-grained model of the E. coli cytoplasm is developed by describing the proteins of the cytoplasm as flexible units consisting of one or more spheres that follow Brownian dynamics (BD), with hydrodynamic interactions (HI) accounted for by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::20710c5a7f0a0381b9a76941d00c73b3
http://www.escholarship.org/uc/item/6pr6r8xc
http://www.escholarship.org/uc/item/6pr6r8xc
Autor:
Silber, BM, Gever, JR, Li, Z, Gallardo-Godoy, A, Renslo, AR, Widjaja, K, Irwin, JJ, Rao, S, Jacobson, MP, Ghaemmaghami, S, Prusiner, SB
Publikováno v:
Silber, BM; Gever, JR; Li, Z; Gallardo-Godoy, A; Renslo, AR; Widjaja, K; et al.(2013). Antiprion compounds that reduce PrPSclevels in dividing and stationary-phase cells. Bioorganic and Medicinal Chemistry, 21(24), 7999-8012. doi: 10.1016/j.bmc.2013.09.022. UCSF: Retrieved from: http://www.escholarship.org/uc/item/0f99q5fm
During prion diseases, a normally benign, host protein, denoted PrPC, undergoes alternative folding into the aberrant isoform, PrPSc. We used ELISA to identify and confirm hits in order to develop leads that reduce PrPScin prion-infected dividing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::c117d6ef559ee62289d2f044f79a3caa
http://www.escholarship.org/uc/item/0f99q5fm
http://www.escholarship.org/uc/item/0f99q5fm
Autor:
Barber, Diane, Jacobson, Matthew, Choi, C-H, Webb, BA, Chimenti, MS, Jacobson, MP, Barber, DL
Publikováno v:
Barber, Diane; Jacobson, Matthew; Choi, C-H; Webb, BA; Chimenti, MS; Jacobson, MP; et al.(2013). pH sensing by FAK-His58 regulates focal adhesion remodeling. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6mz561mb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::78a5f8a1d8aac46dbec403e5ac3f0718
http://www.escholarship.org/uc/item/6mz561mb
http://www.escholarship.org/uc/item/6mz561mb
Publikováno v:
Jacobson, Matthew; Kuroda, D; Shirai, H; Jacobson, MP; & Nakamura, H. (2012). Computer-aided antibody design. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0pn492jg
Recent clinical trials using antibodies with low toxicity and high efficiency have raised expectations for the development of next-generation protein therapeutics. However, the process of obtaining therapeutic antibodies remains time consuming and em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::0372ad730107100a1d4f8964805b0668
http://www.escholarship.org/uc/item/0pn492jg
http://www.escholarship.org/uc/item/0pn492jg