Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jacobsen, John R."'
Publikováno v:
Science, 1997 Jul . 277(5324), 367-369.
Externí odkaz:
https://www.jstor.org/stable/2892862
Autor:
Jacobsen, John R., Schultz, Peter G.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1994 Jun . 91(13), 5888-5892.
Externí odkaz:
https://www.jstor.org/stable/2365078
Autor:
David Beattie, Jacobsen John R, Glenmar P. Obedencio, Scott R. Armstrong, Timothy J. Church, Daniel D. Long, Ross G. Vickery, Pamela R. Tsuruda, Pierre-Jean Colson, Christina B. Campbell, Stergiades Ioanna, Miroslav Rapta, Dalziel Sean M, Daisuke Saito, Priscilla Van Dyke, Lan Jiang
Publikováno v:
ACS Med Chem Lett
[Image: see text] The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and addiction, which has contributed to a growing opioid epidemic in the United
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eb2998f1bc2f55f8f113199e7df461
https://europepmc.org/articles/PMC6912869/
https://europepmc.org/articles/PMC6912869/
Autor:
Jacobsen, John R., Prudent, James R., Kochersperger, Lynn, Yonkovich, Shirlee, Schultz, Peter G.
Publikováno v:
Science, 1992 Apr . 256(5055), 365-367.
Externí odkaz:
https://www.jstor.org/stable/2877081
Akademický článek
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Autor:
Jiang, Lan, Beattie, David T., Jacobsen, John R., Kintz, Samuel, Obedencio, Glenmar P., Saito, Daisuke, Stergiades, Ioanna, Vickery, Ross G., Long, Daniel D.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 July 2017 27(13):2926-2930
Autor:
Daniel D. Long, Samuel Kintz, Lan Jiang, Ross G. Vickery, David Beattie, Daisuke Saito, Stergiades Ioanna, Jacobsen John R, Glenmar P. Obedencio
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(13)
Gastrointestinal dysfunction as a consequence of the use of opioid analgesics is of significant clinical concern. First generation drugs to treat these opioid-induced side-effects were limited by their negative impact on opioid receptor agonist-induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f247f59fe80eece43e453df2431f10ec
https://pubmed.ncbi.nlm.nih.gov/28499731
https://pubmed.ncbi.nlm.nih.gov/28499731
Autor:
Matthew B Nodwell, G. Roger Thomas, Edmund J. Moran, Juergen W. Pfeiffer, Martin S. Linsell, Uwe Klein, Cecile Yu, Jacobsen John R, R. Murray McKinnell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2871-2876
A multivalent approach focused on amine-based secondary binding groups was applied to the discovery of long-acting inhaled β2-agonists. Addition of amine moieties to the neutral secondary binding group of an existing β2-agonist series was found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e63611622bf41320ee0b1be430ab4f2
https://doi.org/10.1016/j.bmcl.2014.04.095
https://doi.org/10.1016/j.bmcl.2014.04.095
Autor:
Cecile Yu, Uwe Klein, Eric Fournier, Jesse D. Combs, Jacobsen John R, G. Roger Thomas, Juergen W. Pfeiffer, Edmund J. Moran, Seok-Ki Choi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1213-1218
A multivalent approach was applied to the design of long-acting inhaled β(2)-adrenoceptor agonists. A series of dimeric arylethanolamines based on the short acting β(2)-adrenoceptor agonist albuterol were prepared, varying the nature and length of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e97db1149e913ebc6365df69b1fac0
https://doi.org/10.1016/j.bmcl.2011.11.072
https://doi.org/10.1016/j.bmcl.2011.11.072
Autor:
Long, Daniel D., Armstrong, Scott R., Beattie, David T., Campbell, Christina B., Church, Timothy J., Colson, Pierre-Jean, Dalziel, Sean M., Jacobsen, John R., Jiang, Lan, Obedencio, Glenmar P., Rapta, Miroslav, Saito, Daisuke, Stergiades, Ioanna, Tsuruda, Pamela R., Van Dyke, Priscilla M., Vickery, Ross G.
Publikováno v:
ACS Medicinal Chemistry Letters; 2019, Vol. 10 Issue 12, p1641-1647, 7p