Výsledky vyhledávání - "Jacobsen, J.P."

α‐L‐LNA (α‐L‐ribo Configured Locked Nucleic Acid) Recognition of DNA: An NMR Spectroscopic Study:An NMR spectroscopic study

Autor: Nielsen, K.M.E., Petersen, M., Håkansson, A.E., Wengel, J., Jacobsen, J.P.

Publikováno v: Nielsen, K M E, Petersen, M, Håkansson, A E, Wengel, J & Jacobsen, J P 2002, ' α-L-LNA (α-L-ribo Configured Locked Nucleic Acid) Recognition of DNA: An NMR Spectroscopic Study : An NMR spectroscopic study ', Chemistry: A European Journal, vol. 8, no. 13, pp. 3001-3009 . https://doi.org/10.1002/1521-3765(20020703)8:13<3001::AID-CHEM3001>3.0.CO;2-1

We have used NMR and CD spectroscopy to study and characterise two α‐L‐LNA:DNA duplexes, a nonamer that incorporates three α‐L‐LNA nucleotides and a decamer that incorporates four α‐L‐LNA nucleotides, in which α‐L‐LNA is α‐L‐

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α-l-LNA (α-i-ribo Configured Locked Nucleic Acid) Recognition of RNA. A Study by NMR Spectroscopy and Molecular Dynamics Simulations:A study by NMR spectroscopy and molecular dynamics simulations

Autor: Petersen, M., Håkansson, A.E., Wengel, J., Jacobsen, J.P.

Publikováno v: Petersen, M, Håkansson, A E, Wengel, J & Jacobsen, J P 2001, ' α-l-LNA (α-i-ribo Configured Locked Nucleic Acid) Recognition of RNA. A Study by NMR Spectroscopy and Molecular Dynamics Simulations : A study by NMR spectroscopy and molecular dynamics simulations ', Journal of the American Chemical Society, vol. 123, no. 30, pp. 7431–7432 . https://doi.org/10.1021/ja010557u

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The solution structure of a Locked Nucleic Acid (LNA) hybridized to DNA: NMR study of the d(CTLGCTLTLCTLGC):d(GCAGAAGCAG) duplex containig four locked nucleotides

Autor: Nielsen, K.E., Singh, S.K., Wengel, J., Jacobsen, J.P.

Publikováno v: Nielsen, K E, Singh, S K, Wengel, J & Jacobsen, J P 2000, ' The solution structure of a Locked Nucleic Acid (LNA) hybridized to DNA: NMR study of the d(CTLGCTLTLCTLGC):d(GCAGAAGCAG) duplex containig four locked nucleotides ', Bioconjugate Chemistry, vol. 11, no. 2, pp. 228–238 . https://doi.org/10.1021/bc990121s

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Concerted intercalation and minor groove recognition of DNA by a homodimeric thiazole orange dye

Autor: Bunkenborg, J., Gadjev, N.I., Deligeorgiev, T., Jacobsen, J.P.

Publikováno v: Bunkenborg, J, Gadjev, N I, Deligeorgiev, T & Jacobsen, J P 2000, ' Concerted intercalation and minor groove recognition of DNA by a homodimeric thiazole orange dye ', Bioconjugate Chemistry, vol. 11, pp. 861-67 .

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The solution structure of a DNA duplex containing a single 1-(2-O,3-C-ethylene-?-D-arabinofuranosyl)thymidine nucleoside

Autor: Jørgensen, L.B., Nielsen, P., Wengel, J., Jacobsen, J.P.

Publikováno v: Jørgensen, L B, Nielsen, P, Wengel, J & Jacobsen, J P 2000, ' The solution structure of a DNA duplex containing a single 1-(2-O,3-C-ethylene-?-D-arabinofuranosyl)thymidine nucleoside ', Journal of Biomolecular Structure & Dynamics, vol. 18, no. 1, pp. 45-57 . https://doi.org/10.1080/07391102.2000.10506646

The structure of a DNA duplex containing one 1-(2-0,3-C-ethylene-β-D-arabinofuranosyl)- thymidine nucleoside (T5) modification was investigated by use of two-dimensional 1H NMR spectroscopy at 750 MHz. The structure of the d(CCGCT5AGCG):d(CGCTAGCGG)

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Structural studies of LNA:RNA duplexes by NMR:Conformations and implications for RNase H activity

Autor: Bondensgaard, K., Petersen, M., Singh, S.K., Rajwanshi, V.K., Kumar, R., Wengel, J., Jacobsen, J.P.

Publikováno v: Bondensgaard, K, Petersen, M, Singh, S K, Rajwanshi, V K, Kumar, R, Wengel, J & Jacobsen, J P 2000, ' Structural studies of LNA:RNA duplexes by NMR : Conformations and implications for RNase H activity ', Chemistry: A European Journal, vol. 6, no. 15, pp. 2687-2695 . https://doi.org/10.1002/1521-3765(20000804)6:15<2687::AID-CHEM2687>3.0.CO;2-U

We have used NMR and CD spectroscopy to study the conformations of modified oligonucleotides (locked nucleic acid, LNA) containing a conformationally restricted nucleotide (TL) with a 2′‐O,4′‐C‐methylene bridge. We have investigated two LNA

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