Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jacobo López‐Abente"'
Autor:
Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec
Externí odkaz:
https://doaj.org/article/eeac938a111045e186e031edbfe48da6
Autor:
Jacobo López-Abente, Marta Martínez-Bonet, Esther Bernaldo-de-Quirós, Manuela Camino, Nuria Gil, Esther Panadero, Juan Miguel Gil-Jaurena, Maribel Clemente, Simon Urschel, Lori West, Marjorie Pion, Rafael Correa-Rocha
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract CD25, the alpha chain of the IL-2 receptor, is expressed on activated effector T cells that mediate immune graft damage. Induction immunosuppression is commonly used in solid organ transplantation and can include antibodies blocking CD25. Ho
Externí odkaz:
https://doaj.org/article/4c11fa0c07a241ce8f6dbe296a31b180
Autor:
Sophie Papa, James Spicer, Debra H Josephs, Giulia Pellizzari, Olivier Martinez, Silvia Crescioli, Robert Page, Ashley Di Meo, Silvia Mele, Giulia Chiaruttini, Jan Hoinka, Ihor Batruch, Ioannis Prassas, Melanie Grandits, Jacobo López-Abente, Eva Bugallo-Blanco, Malcolm Ward, Heather J Bax, Elise French, Anthony Cheung, Sara Lombardi, Mariangela Figini, Katie E Lacy, Eleftherios P Diamandis, Sophia N Karagiannis
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Cancer immunotherapy with monoclonal antibodies and chimeric antigen receptor (CAR) T cell therapies can benefit from selection of new targets with high levels of tumor specificity and from early assessments of efficacy and safety to deris
Externí odkaz:
https://doaj.org/article/836d29985b964cc8b16ff8085298d717
Autor:
Esther Bernaldo-de-Quirós, MSc, Jacobo López-Abente, PhD, Manuela Camino, MD, Nuria Gil, MD, Esther Panadero, MD, Rocío López-Esteban, Marta Martínez-Bonet, PhD, Marjorie Pion, PhD, Rafael Correa-Rocha, PhD
Publikováno v:
Transplantation Direct, Vol 7, Iss 5, p e693 (2021)
Background. Regulatory T cells (Treg) are crucial for the induction and maintenance of graft tolerance. In pediatric heart transplant procedures, the thymus is routinely excised, removing the primary source of T-cell replenishment. Consequently, thym
Externí odkaz:
https://doaj.org/article/6ed1622c042046f0bdc62d8f27e2a308
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/3a85893a53e14bfcbd898253f8383153
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Regulatory T cells (Tregs) play an important role in infections, by modulating host immune responses and avoiding the overreactive immunity that in the case of human immunodeficiency virus (HIV) infection leads to a marked erosion and deregulation of
Externí odkaz:
https://doaj.org/article/ca9718bdc7b24a4abd348b4efe8ec612
Autor:
Heather J. Bax, Jitesh Chauhan, Chara Stavraka, Aida Santaolalla, Gabriel Osborn, Atousa Khiabany, Melanie Grandits, Jacobo López-Abente, Lais C. G. F. Palhares, Charleen Chan Wah Hak, Alexandra Robinson, Amy Pope, Natalie Woodman, Cristina Naceur-Lombardelli, Sadek Malas, Jack E. M. Coumbe, Mano Nakamura, Roman Laddach, Silvia Mele, Silvia Crescioli, Anna M. Black, Sara Lombardi, Silvana Canevari, Mariangela Figini, Ahmad Sayasneh, Sophia Tsoka, Kevin FitzGerald, Cheryl Gillett, Sarah Pinder, Mieke Van Hemelrijck, Rebecca Kristeleit, Sharmistha Ghosh, Ana Montes, James Spicer, Sophia N. Karagiannis, Debra H. Josephs
Publikováno v:
Bax, H, Chauhan, J, Stavraka, C, Santaolalla, A, Osborn, G, Khiabany, A, Grandits, M, Lopez-Abente Muroz, J, Gusmao Ferreira, L C, Chan Wah Hak, C, Robinson, A, Pope, A, Woodman, N, Naceur-Lombardelli, C, Malas, S, Nakamura, M, Coumbe, J E M, Laddach, R, Mele, S, Crescioli, S, Black, A, Lombardi, S, Canevari, S, Figini, M, Sayasneh, A, Tsoka, S, FitzGerald, K, Gillett, C, Pinder, S, Van Hemelrijck, M, Kristeleit, R, Ghosh, S, Montes, A, Spicer, J, Karagiannis, S N & Josephs, D 2022, ' Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes ', British Journal of Cancer . https://doi.org/10.1038/s41416-022-02031-x
Background Survival rates for ovarian cancer remain poor, and monitoring and prediction of therapeutic response may benefit from additional markers. Ovarian cancers frequently overexpress Folate Receptor alpha (FRα) and the soluble receptor (sFRα)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540f460d63dc952bc739807eae588499
https://doi.org/10.1038/s41416-022-02031-x
https://doi.org/10.1038/s41416-022-02031-x
Autor:
Oscar Palomares, Alba Angelina, Beate Rückert, Mar Martín-Fontecha, Mario Pérez-Diego, Cezmi A. Akdis, Jacobo López-Abente, Ivan Nombela, Mübeccel Akdis
Publikováno v:
Mucosal Immunology
E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense. Archivo Institucional de la UCM
instname
The generation of functional regulatory T cells (Tregs) is essential to keep tissue homeostasis and restore healthy immune responses in many biological and inflammatory contexts. Cannabinoids have been pointed out as potential therapeutic tools for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c977b05817f29b3a590b7e8417d7c4
https://doi.org/10.1038/s41385-021-00455-x
https://doi.org/10.1038/s41385-021-00455-x
Autor:
Cristina Benito‐Villalvilla, Andrés de la Rocha‐Muñoz, Jacobo López‐Abente, Alexander Eggel, Iván Bottoli, Thomas Severin, Maximilian Woisetschläger, Oscar Palomares
Background Ligelizumab is an anti-IgE monoclonal antibody binding IgE with higher affinity than omalizumab that is under clinical investigation for several IgE-mediated diseases. We previously showed that omalizumab removes IgE bound to FcεRI on pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71836badbf1626bec99e45f97240959b
https://eprints.ucm.es/id/eprint/75657/
https://eprints.ucm.es/id/eprint/75657/
Autor:
Esther Bernaldo-de-Quirós, Marjorie Pion, Rafael Correa-Rocha, Nuria Gil, Maribel Clemente, Marta Martínez-Bonet, Simon Urschel, Manuela Camino, Esther Panadero, Lori J. West, Juan Miguel Gil-Jaurena, Jacobo López-Abente
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
CD25, the alpha chain of the IL-2 receptor, is expressed on activated effector T cells that mediate immune graft damage. Induction immunosuppression is commonly used in solid organ transplantation and can include antibodies blocking CD25. However, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70a3f09eb95d8e6b3fb8c7adf13691f
https://doaj.org/article/4c11fa0c07a241ce8f6dbe296a31b180
https://doaj.org/article/4c11fa0c07a241ce8f6dbe296a31b180