Age and sex associate with outcome in older AML and high risk MDS patients treated with 10-day decitabine

Autor: Jacobien R. Hilberink, Isabelle A. van Zeventer, Dana A. Chitu, Thomas Pabst, Saskia K. Klein, Georg Stussi, Laimonas Griskevicius, Peter J. M. Valk, Jacqueline Cloos, Arjan A. van de Loosdrecht, Dimitri Breems, Danielle van Lammeren-Venema, Rinske Boersma, Mojca Jongen-Lavrencic, Martin Fehr, Mels Hoogendoorn, Markus G. Manz, Maaike Söhne, Rien van Marwijk Kooy, Dries Deeren, Marjolein W. M. van der Poel, Marie Cecile Legdeur, Lidwine Tick, Yves Chalandon, Emanuele Ammatuna, Sabine Blum, Bob Löwenberg, Gert J. Ossenkoppele, Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON), Swiss Group for Clinical Cancer Research (SAKK), Gerwin Huls

Publikováno v: Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)

Abstract Treatment choice according to the individual conditions remains challenging, particularly in older patients with acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS). The impact of performance status, comorbidities, and

Externí odkaz: https://doaj.org/article/71614de5d82b474e855269ada1ea2dee

Thiostrepton induces cell death of acute myeloid leukemia blasts and the associated macrophage population

Autor: Isabel Weinhäuser, Diego A. Pereira-Martins, Jacobien R. Hilberink, Annet Brouwers-Vos, Eduardo M. Rego, Gerwin Huls, Jan Jacob Schuringa

Publikováno v: Haematologica, Vol 109, Iss 2 (2023)

Externí odkaz: https://doaj.org/article/a6032b8c6c124d25b2bc7e7184f7b3c6

Killing the enemy or making it your ally? The effects of thiostrepton on tumor associated macrophages

Autor: Diego A. Pereira-Martins, Jacobien R. Hilberink, Isabel Weinhäuser, Eduardo M. Rego, Gerwin Huls, Jan Jacob Schuringa

Attempts to convert a tumor supportive M2-polarized macrophage microenvironment into a tumor suppressive M1-polarized one have recently received considerable attention. However, the specificity of novel compounds, their mode-of-action, and efficacy o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::717359df061dfc9ae44a75f9215127cc
https://doi.org/10.1101/2023.03.23.533899

Secondary cytogenetic abnormalities in core-binding factor AML harboring inv(16) vs t(8;21)

Autor: Hans-Peter Horny, Cecilia Arana Yi, Celalettin Ustun, Cecilia C. S. Yeung, Jason Gotlib, Christina Cho, Tracy I. George, David R. Czuchlewski, Jessica Kohlschmidt, Amandeep Salhotra, Ryotaro Nakamura, Sheeja T. Pullarkat, Gerwin Huls, Linda B. Baughn, Robert S. Ohgami, Jenna M. Voutsinas, Cem Akin, Wolfgang R. Sperr, Guido Marcucci, Jason L. Hornick, Young L. Kim, Hanne Vestergaard, Qian Wu, Gautam Borthakur, Gregor Hoermann, Mark R. Litzow, Michael Boe Møller, Peter Valent, Dong Chen, Jacobien R. Hilberink, Miguel-Angel Perales, Melissa L. Larson, Thomas Kielsgaard Kristensen, Michael A. Linden, Ana Iris Schiefer, Philip M. Kluin, Daniel J. Weisdorf, Clara D. Bloomfield, Vinod Pullarkat, Michelle M Dolan, Se young Han, Nam K. Ku, H. Joachim Deeg, Krzysztof Mrózek, Sigurd Broesby-Olsen, Elizabeth A. Morgan, Lori Soma

Publikováno v: Blood, 5(10), 2481-2489. AMER SOC HEMATOLOGY
Blood Adv
Han, S Y, Mrózek, K, Voutsinas, J, Wu, Q, Morgan, E A, Vestergaard, H, Ohgami, R, Kluin, P M, Kristensen, T K, Pullarkat, S, Møller, M B, Schiefer, A I, Baughn, L B, Kim, Y, Czuchlewski, D, Hilberink, J R, Horny, H P, George, T I, Dolan, M, Ku, N K, Yi, C A, Pullarkat, V, Kohlschmidt, J, Salhotra, A, Soma, L, Bloomfield, C D, Chen, D, Sperr, W R, Marcucci, G, Cho, C, Akin, C, Gotlib, J, Broesby-Olsen, S, Larson, M, Linden, M A, Deeg, H J, Hoermann, G, Perales, M A, Hornick, J L, Litzow, M R, Nakamura, R, Weisdorf, D, Borthakur, G, Huls, G, Valent, P, Ustun, C & Yeung, C C S 2021, ' Secondary cytogenetic abnormalities in core-binding factor AML harboring inv(16) vs t(8;21) ', Blood Advances, vol. 5, no. 10, pp. 2481-2489 . https://doi.org/10.1182/BLOODADVANCES.2020003605

Patients with core-binding factor (CBF) acute myeloid leukemia (AML), caused by either t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22), have higher complete remission rates and longer survival than patients with other subtypes of AML. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ec31531cd96949802b2792505f618e
https://hdl.handle.net/11370/41555cb2-e320-49c6-aae6-901adc6fa7a5

Functional Drug Screen Identifies Thiostrepton, NAMPT Inhibitors and Metformin As Potential Candidates to Target the Macrophage Tumor Microenvironment in Acute Myeloid Leukemia

Autor: Isabel Weinhaeuser, Diego Pereira-Martins, Jacobien R Hilberink, Emanuele Ammatuna, Gerwin A. Huls, Eduardo M Rego, Jan Jacob Schuringa

Publikováno v: Blood. 140:8793-8794

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94cafc6469e56269fb72b3ca84d6cd37
https://doi.org/10.1182/blood-2022-165115