Výsledky vyhledávání

Structural Characterization of Diazabicyclooctane β-Lactam 'Enhancers' in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

Autor: Focco van den Akker, Malligarjunan Rajavel, Steven H. Marshall, Vijay Kumar, Jacob Wyatt, Mahesh Patel, Satish Bhavsar, Ravindra D. Yeole, Prasad K Deshpande, Ha Nguyen, Sachin Bhagwat, Robert A. Bonomo, Krisztina M. Papp-Wallace

Publikováno v: mBio, Vol 12, Iss 1 (2021)
mBio

Multidrug-resistant (MDR) pathogens pose a significant public health threat. A major mechanism of resistance expressed by MDR pathogens is β-lactamase-mediated degradation of β-lactam antibiotics. The diazabicyclooctane (DBO) compounds zidebactam a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19974c9ff06dce243112527595e9bf7
https://journals.asm.org/doi/10.1128/mBio.03058-20

Zobrazit plný text záznamu

Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3

Autor: Eric Desarbre, Vijay Kumar, Jacob Wyatt, Christopher R. Bethel, Krisztina M. Papp-Wallace, Robert A. Bonomo, Christie Tang, Focco van den Akker

Publikováno v: Antimicrob Agents Chemother

Ceftobiprole is an advanced-generation broad-spectrum cephalosporin antibiotic with potent and rapid bactericidal activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, as well as susceptible Gram-negative pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25d64077f591d62c7ae26cba3c3da0c
https://doi.org/10.1128/aac.00106-20

Zobrazit plný text záznamu