Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jacob W. McCabe"'
Autor:
Adam P. Huntley, Jixing Lyu, Jacob W. McCabe, Nathan M. Hoffman, Vicki H. Wysocki, Arthur Laganowsky, Thomas E. Walker, David H. Russell, Robert L. Schrader, Gordon A. Anderson, Peter T. A. Reilly, Benjamin J. Jones
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32:2812-2820
Here, we describe a digital-waveform dual-quadrupole mass spectrometer that enhances the performance of our drift tube FT-IMS high-resolution Orbitrap mass spectrometer (MS). The dual-quadrupole analyzer enhances the instrument capabilities for studi
Autor:
Cheng-Wei Lin, Arthur Laganowsky, David H. Russell, Jacob W. McCabe, David P. Barondeau, Thomas E. Walker, Benjamin J. Jones, Mehdi Shirzadeh, David E. Clemmer, Vicki H. Wysocki
Publikováno v:
Anal Chem
Stabilities and structure(s) of proteins are directly coupled to their local environment or Gibbs free energy landscape as defined by solvent, temperature, pressure, and concentration. Solution pH, ionic strength, cofactors, chemical chaperones, and
Autor:
Arthur Laganowsky, David H. Russell, Minglei Zhao, Jacob W. McCabe, Mariah Bartz, Samantha Schrecke, Charles Packianathan, Yun Zhu, Ming Zhou
Publikováno v:
Nature chemical biology
TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with roles in maintaining the resting membrane potential and fast action potential conduction. Regulated by a wide range of physical and chemical stimuli, the affinity an
Autor:
Mehdi Shirzadeh, Michael L. Poltash, Xueyun Zheng, Klaudia I. Kocurek, Shiyu Dong, Cheng-Wei Lin, Ting Jiang, Arthur Laganowsky, Michael J. Hebert, David H. Russell, Liqi Fan, Christopher S. Mallis, Jacob W. McCabe, Thomas E. Walker
Publikováno v:
Anal Chem
Rotationally averaged collision cross section (CCS) values for a series of proteins and protein complexes ranging in size from 8.6 to 810 kDa are reported. The CCSs were obtained using a native electrospray ionization drift tube ion mobility-Orbitrap
Autor:
Smriti Kumar, Samantha Schrecke, David H. Russell, Jacob W. McCabe, Arthur Laganowsky, Tianqi Zhang, Pei Qiao, Jixing Lyu, Thomas E. Walker, Yun Zhu, David E. Clemmer
Publikováno v:
J Phys Chem Lett
Understanding the molecular driving forces that underlie membrane protein-lipid interactions requires the characterization of their binding thermodynamics. Here, we employ native mass spectrometry in conjunction with a variable temperature apparatus
Autor:
David H. Russell, He Mirabel Sun, Mehdi Shirzadeh, Zahra Moghadamchargari, Hays S. Rye, Jacob W. McCabe, Thomas E. Walker, David E. Clemmer, Arthur Laganowsky, Andrew Roth
Publikováno v:
J Am Chem Soc
Chaperonins are nanomachines that harness ATP hydrolysis to power and catalyze protein folding, chemical action that is directly linked to the maintenance of cell function through protein folding/refolding and assembly. GroEL and the GroEL-GroES comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be4072cb1756453072d0f580287805d
https://doi.org/10.33774/chemrxiv-2021-vk20s-v2
https://doi.org/10.33774/chemrxiv-2021-vk20s-v2
Autor:
Jacob W, McCabe, Benjamin J, Jones, Thomas E, Walker, Robert L, Schrader, Adam P, Huntley, Jixing, Lyu, Nathan M, Hoffman, Gordon A, Anderson, Peter T A, Reilly, Arthur, Laganowsky, Vicki H, Wysocki, David H, Russell
Publikováno v:
J Am Soc Mass Spectrom
Here, we describe a digital-waveform dual-quadrupole mass spectrometer that enhances the performance of our drift tube FT-IMS high-resolution Orbitrap mass spectrometer (MS). The dual-quadrupole analyzer enhances the instrument capabilities for studi
Autor:
Jacob W. McCabe, David H. Russell, Zahra Moghadamchargari, Arthur Laganowsky, Mehdi Shirzadeh, Michael L. Poltash
Publikováno v:
Chemical Communications. 55:4091-4094
The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leadin
Autor:
Yang Liu, David H. Russell, Arthur Laganowsky, Samantha Schrecke, Jixing Lyu, Jacob W. McCabe, Lei Fang
Publikováno v:
Anal Chem
There is growing interest in the characterization of protein complexes and their interactions with ligands using native ion mobility mass spectrometry. A particular challenge, especially for membrane proteins, is preserving noncovalent interactions a
Autor:
David H. Russell, Mehdi Shirzadeh, Christopher S. Mallis, Jacob W. McCabe, Joanna K. Denton, Michael J. Hebert, Thomas E. Walker
Publikováno v:
Mass Spectrom Rev
Studies of large proteins, protein complexes, and membrane protein complexes pose new challenges, most notably the need for increased ion mobility (IM) and mass spectrometry (MS) resolution. This review covers evolutionary developments in IM-MS in th