Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jacob V Gorman"'
Autor:
Yue Liu, Joanna Pagacz, Donald J Wolfgeher, Kenneth D Bromerg, Jacob V Gorman, Stephen J Kron
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Immune tolerance contributes to resistance to conventional cancer therapies such as radiation. Radiotherapy induces immunogenic cell death, releasing a burst of tumor antigens, but this appears insufficient to stimulate an effective antitu
Externí odkaz:
https://doaj.org/article/850cfcfd9d5b4e68a8f837ab9763b19e
Publikováno v:
Immunological investigations. 51(6)
The nonreceptor tyrosine kinase ITK is a key component of the T cell receptor (TCR) signaling pathway and is required for cytokine production by CD4+ T cells that have differentiated into Th2 cells. Structural and biochemical studies suggest that con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18ef54a3d08741bf7362a9701010ed1
https://pubmed.ncbi.nlm.nih.gov/34844506
https://pubmed.ncbi.nlm.nih.gov/34844506
Autor:
Jacob V. Gorman, John D. Colgan
Publikováno v:
Immunology. 154:418-433
T‐cell immunoglobulin and mucin domain 3 (Tim‐3) is a surface receptor expressed by T helper type 1 (Th1) effector CD4 T cells, which are critical for defence against intracellular pathogens and have been implicated in autoimmune disease. Previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18603bc99f55e8eb3dcb27edd7e2891
https://doi.org/10.1111/imm.12890
https://doi.org/10.1111/imm.12890
Autor:
Jacob V. Gorman, John D. Colgan
Publikováno v:
Immunologic Research. 59:56-65
Tim-3 is a member of the T cell immunoglobulin and mucin domain (Tim) family of proteins, which are expressed by several cell types in the immune system, including CD4 and CD8 T cells activated under certain conditions. These molecules are generally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737b86bb2840e1e2f6be6eed79a0301c
https://doi.org/10.1007/s12026-014-8524-1
https://doi.org/10.1007/s12026-014-8524-1
Autor:
Jacob V. Gorman, Geoffrey L. Stephens, Ling-Ling An, Jessica Bonnell, Bonnie Swerdlow, Michael Fung, Paul Warrener, Tomas Mustelin, Roland Kolbeck
Publikováno v:
Scientific Reports
Severe bacterial infection results in both uncontrolled inflammation and immune suppression in septic patients. Although there is ample evidence that complement activation provokes overwhelming pro-inflammatory responses, whether or not it plays a ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e951a9b3dd0c223560141a1386c92403
http://europepmc.org/articles/PMC5022031
http://europepmc.org/articles/PMC5022031
Autor:
Ichiro Kinoshita, Akinori Takaoka, Jacob V. Gorman, Yoichiro Fujioka, Yusuke Ohba, Hisaya Akiba, Mitsuomi Hirashima, Hironori Yoshiyama, John D. Colgan, Hideo Yagita, Shigeki Chiba, Muhammad Baghdadi, Masahisa Jinushi, Toshimitsu Uede, Hirotoshi Dosaka-Akita
Publikováno v:
Nature Immunology. 13(9):832-842
The mechanisms by which tumor microenvironments modulate nucleic acid–mediated innate immunity remain unknown. Here we identify the receptor TIM-3 as key in circumventing the stimulatory effects of nucleic acids in tumor immunity. Tumor-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d517d390eb9490bdde866e0c41abcf46
http://hdl.handle.net/2115/52108
http://hdl.handle.net/2115/52108
Autor:
Thomas R. Businga, Paul B. Rothman, David M. Valenzuela, Joel N. Kline, John D. Colgan, Suzanne L. Cassel, Melody Singh, Miranda L. Curtiss, Geri L. Traver, Andrew J. Murphy, David K. Meyerholz, Jacob V. Gorman
Publikováno v:
European Journal of Immunology. 42:651-661
T cell immunoglobulin mucin-1 (Tim-1) is a transmembrane protein postulated to be a key regulator of Th2-type immune responses. This hypothesis is based in part upon genetic studies associating Tim-1 polymorphisms in mice with a bias toward airway hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47b41f22b31dbe25d6f6ff92b612aa4
https://doi.org/10.1002/eji.201141581
https://doi.org/10.1002/eji.201141581
Autor:
John D. Colgan, Binh Phong, Lawrence P. Kane, Tina L. Sumpter, Simon C. Watkins, Lyndsay Avery, Jacob V. Gorman
Publikováno v:
The Journal of Experimental Medicine
Phong et al. show that depending on the expression of p-Lyn, mast cell activation by antigen can result in dichotomous effects on mast cell function and signaling that can be accentuated by Tim-3 ligation.
T cell (or transmembrane) immunoglobuli
T cell (or transmembrane) immunoglobuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf80bc1f6a93fe951ac3bb787692b56
https://pubmed.ncbi.nlm.nih.gov/26598760
https://pubmed.ncbi.nlm.nih.gov/26598760
Autor:
Jacob V. Gorman, John D. Colgan
We thank Dr. Kuchroo and colleagues for their interest in our paper (1) and their commentary. The studies we described consist of two parts. In the first part, we compared CD8 T cell responses by wild-type (WT) C57BL/6J (B6) mice and Tim-3 KO mice to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22f4352f788e42775127479c80898cb
https://europepmc.org/articles/PMC4729293/
https://europepmc.org/articles/PMC4729293/
