Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jacob T. Williams"'
Autor:
Staci L. Haney, Michelle L. Varney, Jacob T. Williams, Lynette M. Smith, Geoffrey Talmon, Sarah A. Holstein
Publikováno v:
Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Background Multiple myeloma (MM) remains an incurable malignancy, despite the advent of therapies such as proteosome inhibitors (PIs) that disrupt protein homeostasis and induce ER stress. We have pursued inhibition of geranylgeranyl diphosp
Externí odkaz:
https://doaj.org/article/1de658b7b5734f53ac2c8d0362bbbce0
Autor:
Ken Flanagan, Romika Kumari, Juho J. Miettinen, Staci L. Haney, Michelle L. Varney, Jacob T. Williams, Muntasir M. Majumder, Minna Suvela, Ana Slipicevic, Fredrik Lehmann, Nina N. Nupponen, Sarah A. Holstein, Caroline A. Heckman
Publikováno v:
HemaSphere, Vol 6, Iss 3, p e687 (2022)
Immunoglobulin light-chain (AL) amyloidosis is a rare disease caused by clonal plasma cell secretion of misfolded light chains that assemble as toxic amyloid fibrils, depositing in vital organs including the heart and kidneys, causing organ dysfuncti
Externí odkaz:
https://doaj.org/article/9b8d9fd8a74e40a7942a0ec1bf52d4d7
Autor:
Staci L. Haney, Dan Feng, Yashpal S. Chhonker, Michelle L. Varney, Jacob T. Williams, Lynette M. Smith, James B. Ford, Daryl J. Murry, Sarah A. Holstein
Publikováno v:
Drug Development Research. 84:62-74
Rab GTPases are critical regulators of protein trafficking in the cell. To ensure proper cellular localization and function, Rab proteins must undergo a posttranslational modification, termed geranylgeranylation. In the isoprenoid biosynthesis pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba636d175e4847ed957978b02fdcaf1
https://doi.org/10.1002/ddr.22012
https://doi.org/10.1002/ddr.22012
Autor:
R. Katherine Hyde, Catalina Amador, Jacob T. Williams, Rachel A. Coburn, Michelle E. Becker, Yiqian Wang, Lisa E. Richter
Supplemental Figure 1. HDAC2 binding to CBFβ-SMMHC is not detected in transfected COS-7 cells. Supplemental Figure 2. CBFB-MYH11N63K, N104K, Î"179-221 mutant eliminates RUNX1 binding. Supplemental Figure 3. CBFB does not Co-IP with HDAC1. Supplem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206f62a25cdebde28a01e7d6ccda488e
https://doi.org/10.1158/1541-7786.22516240.v1
https://doi.org/10.1158/1541-7786.22516240.v1
Autor:
R. Katherine Hyde, Catalina Amador, Jacob T. Williams, Rachel A. Coburn, Michelle E. Becker, Yiqian Wang, Lisa E. Richter
Acute myeloid leukemia (AML) is a neoplastic disease characterized by the uncontrolled proliferation and accumulation of immature myeloid cells. A common mutation in AML is the inversion of chromosome 16 [inv (16)], which generates a fusion between t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aad4e1476dbc13e27bdf7f70c2068ec
https://doi.org/10.1158/1541-7786.c.6541321
https://doi.org/10.1158/1541-7786.c.6541321
Autor:
R. Katherine Hyde, Lisa Richter, Yu Hang, Yiqian Wang, Michelle Becker, Jacob T. Williams, Ying Xie, David Oupický, Catalina Amador
Publikováno v:
Cancer gene therapy. 27(1-2)
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults and is associated with poor long-term survival often owing to relapse. Current treatments for AML are associated with considerable toxicity and are frequently not effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61104315c4f4d7848d2866af3501f84d
https://pubmed.ncbi.nlm.nih.gov/31028289
https://pubmed.ncbi.nlm.nih.gov/31028289
Autor:
Lisa E. Richter, Yiqian Wang, Rachel A. Coburn, Michelle Becker, R. Katherine Hyde, Jacob T. Williams, Catalina Amador
Publikováno v:
Mol Cancer Res
Acute myeloid leukemia (AML) is a neoplastic disease characterized by the uncontrolled proliferation and accumulation of immature myeloid cells. A common mutation in AML is the inversion of chromosome 16 [inv (16)], which generates a fusion between t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9110b07e2ca6d3a7c40f140174691e25
https://pubmed.ncbi.nlm.nih.gov/30814129
https://pubmed.ncbi.nlm.nih.gov/30814129
Autor:
Haney, Staci L.1 (AUTHOR), Varney, Michelle L.1 (AUTHOR), Williams, Jacob T.1 (AUTHOR), Smith, Lynette M.2 (AUTHOR), Talmon, Geoffrey3 (AUTHOR), Holstein, Sarah A.1 (AUTHOR) sarah.holstein@unmc.edu
Publikováno v:
Experimental Hematology & Oncology. 2/9/2022, Vol. 11 Issue 1, p1-12. 12p.
Autor:
Haney, Staci L., Feng, Dan, Chhonker, Yashpal S., Varney, Michelle L., Williams, Jacob T., Smith, Lynette M., Ford, James B., Murry, Daryl J., Holstein, Sarah A.
Publikováno v:
Drug Development Research; Feb2023, Vol. 84 Issue 1, p62-74, 13p