Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jacob T. Polaski"'
Autor:
Craig M. Rush, Zannel Blanchard, Jacob T. Polaski, Kyle S. Osborne, Krystle Osby, Jeffery M. Vahrenkamp, Chieh-Hsiang Yang, David H. Lum, Christy R. Hagan, Kimberly K. Leslie, Miles A. Pufall, Kristina W. Thiel, Jason Gertz
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Most endometrial cancers express the hormone receptor estrogen receptor alpha (ER) and are driven by excess estrogen signaling. However, evaluation of the estrogen response in endometrial cancer cells has been limited by the availability of
Externí odkaz:
https://doaj.org/article/aac81ba3c33c4f1da08291f62bda8d89
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 1100-1110 (2016)
Riboswitches are mRNA elements regulating gene expression in response to direct binding of a metabolite. While these RNAs are increasingly well understood with respect to interactions between receptor domains and their cognate effector molecules, lit
Externí odkaz:
https://doaj.org/article/2dc694248fd644ec839386d65850c37d
Autor:
Jacob T Polaski, Dylan B Udy, Luisa F Escobar-Hoyos, Gokce Askan, Steven D Leach, Andrea Ventura, Ram Kannan, Robert K Bradley
Publikováno v:
eLife, Vol 10 (2021)
Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but subse
Externí odkaz:
https://doaj.org/article/a9463db9934743749b34293a37a365ef
Autor:
Khrystyna North, Salima Benbarche, Bo Liu, Joseph Pangallo, Sisi Chen, Maximilian Stahl, Jan Philipp Bewersdorf, Robert F. Stanley, Caroline Erickson, Hana Cho, Jose Mario Bello Pineda, James D. Thomas, Jacob T. Polaski, Andrea E. Belleville, Austin M. Gabel, Dylan B. Udy, Olivier Humbert, Hans-Peter Kiem, Omar Abdel-Wahab, Robert K. Bradley
Publikováno v:
Nature Biotechnology. 40:1103-1113
Many cancers carry recurrent, change-of-function mutations affecting RNA splicing factors. Here, we describe a method to harness this abnormal splicing activity to drive splicing factor mutation-dependent gene expression to selectively eliminate tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9303fcac634bc47d4f428a22acb57a
https://doi.org/10.1038/s41587-022-01224-2
https://doi.org/10.1038/s41587-022-01224-2
Autor:
Spencer Arnesen, Jacob T. Polaski, Zannel Blanchard, Kyle S. Osborne, Alana L. Welm, Ryan M. O’Connell, Jason Gertz
Estrogen receptor α (ER) mutations occur in up to 30% of metastatic ER-positive breast cancers. Recent data has shown that ER mutations impact the expression of thousands of genes not typically regulated by wildtype ER. While the majority of these a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dfae674d90e295bf1b2d48777902cea
https://doi.org/10.1101/2022.10.07.511340
https://doi.org/10.1101/2022.10.07.511340
Autor:
Craig M. Rush, Zannel Blanchard, Jacob T. Polaski, Kyle S. Osborne, Krystle Osby, Jeffery M. Vahrenkamp, Chieh-Hsiang Yang, David H. Lum, Christy R. Hagan, Kimberly K. Leslie, Miles A. Pufall, Kristina W. Thiel, Jason Gertz
Most endometrial cancers express the hormone receptor estrogen receptor alpha (ER) and are driven by excess estrogen signaling. However, evaluation of the estrogen response in endometrial cancer cells has been limited by the availability of hormonall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fb88fa8c99e067df976fd979d617c88
https://doi.org/10.1101/2022.08.25.505203
https://doi.org/10.1101/2022.08.25.505203
Autor:
Benjamin H. Durham, Yasutaka Hayashi, Frank McCormick, Sanjoy Mehta, Atsushi Tanaka, Hiromi Yamazaki, Ettaib El Marabti, Chie Fukui, Ralph Garippa, Bo Liu, Guo-Liang Chew, Sydney X. Lu, Jacob T. Polaski, Alex Penson, Justin Taylor, Eric Wang, Sisi Chen, Daichi Inoue, Simon J. Hogg, Daniel Zakheim, Caroline Erickson, Jose Mario Bello Pineda, Miki Fukumoto, Pau Castel, Omar Abdel-Wahab, Susumu Kobayashi, Katherine Knorr, Robert K. Bradley
Publikováno v:
Nature genetics, vol 53, iss 5
Nature genetics
Nature genetics
Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which removes rare, evolutionarily conserved introns. Although hypothesized to serve important regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977cfa901744455e3cb0d97f4b8e8476
https://doi.org/10.1038/s41588-021-00828-9
https://doi.org/10.1038/s41588-021-00828-9
Autor:
Emma R. Hoppe, Jacob T. Polaski, Jacqueline Watson, Robert K. Bradley, Joseph Pangallo, James D. Thomas, Alice H. Berger, Qing Feng, Naomi T. Nkinsi, Austin M. Gabel, Andrea E. Belleville, Emma De Neef, Maria McSharry
Publikováno v:
Nature genetics
While RNA-seq has enabled comprehensive quantification of alternative splicing, no correspondingly high-throughput assay exists for functionally interrogating individual isoforms. We describe pgFARM (paired guide RNAs for alternative exon removal), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8cb8be061554061afee72deccdbce0
https://doi.org/10.1038/s41588-019-0555-z
https://doi.org/10.1038/s41588-019-0555-z
Autor:
Gokce Askan, Jacob T. Polaski, Robert K. Bradley, Luisa F. Escobar-Hoyos, Andrea Ventura, Ram Kannan, Steven D. Leach, Dylan B. Udy
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2afbbaf645a9b57722488e41f402dc1
https://doi.org/10.7554/elife.62209
https://doi.org/10.7554/elife.62209
Author response: The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma
Autor:
Robert K. Bradley, Jacob T. Polaski, Andrea Ventura, Steven D. Leach, Luisa F. Escobar-Hoyos, Gokce Askan, Ram Kannan, Dylan B. Udy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fb79c425075a5cc6959798233efbda8
https://doi.org/10.7554/elife.62209.sa2
https://doi.org/10.7554/elife.62209.sa2