Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jacob Strouse"'
Autor:
Lucas Wise, Sabrina Marecos, Katie Randolph, Mohamed Hassan, Eric Nshimyumukiza, Jacob Strouse, Farshid Salimijazi, Buz Barstow
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Global consumption of protein is projected to double by the middle of the 21st century. However, protein production is one of the most energy intensive and environmentally damaging parts of the food supply system today. Electromicrobial production te
Externí odkaz:
https://doaj.org/article/2cf8f899e0774a37adb906215a0b61cc
Autor:
Irena Ivnitski-Steele, Brian C. Monk, Kurt Lackovic, Richard D. Cannon, J. Jacob Strouse, Mikhail V. Keniya, Larry A. Sklar, Tony S. Cardno, Ann R. Holmes
Publikováno v:
Future Medicinal Chemistry. 8:1485-1501
Resistance to antifungal drugs is an increasingly significant clinical problem. The most common antifungal resistance encountered is efflux pump-mediated resistance of Candida species to azole drugs. One approach to overcome this resistance is to inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6079c96ff16c2c44a2aa494a32a89687
https://doi.org/10.4155/fmc-2016-0050
https://doi.org/10.4155/fmc-2016-0050
Autor:
Gregory W. Fisher, Kristine Gouveia, Yang Wu, Shaun R. Stauffer, Alan S. Waggoner, Christopher Szent-Gyorgyi, Annette M. Evangelisti, Mike Poslusney, Cristian Bologa, Larry A. Sklar, Craig W. Lindsley, Anna Waller, Oleg Ursu, Jonathan W. Jarvik, Robyn L. Stanfield, Phillip H. Tapia, J. Jacob Strouse, Mark B. Carter
Publikováno v:
SLAS Discovery. 21:74-87
A new class of biosensors, fluorogen activating proteins (FAPs), has been successfully used to track receptor trafficking in live cells. Unlike the traditional fluorescent proteins (FPs), FAPs do not fluoresce unless bound to their specific small-mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6370374a2170d95abf28784c8d4b965
https://doi.org/10.1177/1087057115609145
https://doi.org/10.1177/1087057115609145
Autor:
George P. Tegos, Richard S. Larson, J. Jacob Strouse, Virginia M. Salas, Mark B. Carter, Susan M. Young, Irena Ivnitski-Steele, Annette M. Evangelisti, Anna Waller, Tudor I. Oprea, Cristian Bologa, Larry A. Sklar, Oleg Ursu, Dominique Perez, Bruce S. Edwards
Publikováno v:
Analytical Biochemistry. 437:77-87
ATP binding cassette (ABC) transmembrane efflux pumps such as P-glycoprotein (ABCB1), multidrug resistance protein 1 (ABCC1), and breast cancer resistance protein (ABCG2) play an important role in anti-cancer drug resistance. A large number of struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c536d10f8a3d01534e3ab9a1036003
https://doi.org/10.1016/j.ab.2013.02.018
https://doi.org/10.1016/j.ab.2013.02.018
Autor:
Jennifer E. Golden, J. Jacob Strouse, Lin Hong, Mark B. Carter, Anna Waller, Jeffrey Aubé, Oleg Ursu, Tione Buranda, Tudor I. Oprea, S. Ray Kenney, Julica Nöth, Genevieve K Phillips, Alexandre Chigaev, Brian Hjelle, Scarlett Swanson, Laurie G. Hudson, Angela Wandinger-Ness, Elsa Romero, Chad E. Schroeder, Denise S. Simpson, Larry A. Sklar
Publikováno v:
The Journal of Biological Chemistry
Background: By integrating extracellular signals with actin cytoskeletal changes, Cdc42 plays important roles in cell physiology and has been implicated in human diseases. Results: A small molecule was found to selectively inhibit Cdc42 in biochemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bc9bda271d6eda398ff9dd41ec6063
http://europepmc.org/articles/PMC3605667
http://europepmc.org/articles/PMC3605667
Autor:
George P. Tegos, Cristian Bologa, J. Jacob Strouse, Tudor I. Oprea, Mohiuddin Md. Taimur Khan, Mark K. Haynes, Larry A. Sklar
Publikováno v:
Current Pharmaceutical Design. 17:1291-1302
Traditional antimicrobials are increasingly suffering from the emergence of multidrug resistance among pathogenic microorganisms. To overcome these deficiencies, a range of novel approaches to control microbial infections are under investigation as p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee333f1681fa4f2456df2e271055e850
https://doi.org/10.2174/138161211795703726
https://doi.org/10.2174/138161211795703726
Autor:
William B. Parker, J. Jacob Strouse, Colleen B. Jonsson, Yanjie Sun, Jeffrey B. Arterburn, Donghoon Chung
Publikováno v:
Antiviral Research. 83:80-85
As part of an ongoing effort to develop new antiviral nucleoside analogs, our interest was drawn to N(1)-aryl purines as a novel structural class and potential scaffold for drug discovery. Herein, we describe the synthesis of N(1)-3-fluorophenyl-inos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602e3cdf4538748cef6c5e44dcf0f835
https://doi.org/10.1016/j.antiviral.2009.03.007
https://doi.org/10.1016/j.antiviral.2009.03.007
Autor:
Bruce S. Edwards, Hugh D. Mitchell, Eric R. Prossnitz, Larry A. Sklar, Susan M. Young, J. Jacob Strouse, Richard D. Ye
Publikováno v:
Cytometry Part A. :264-270
Formylpeptide receptors (FPRs) are implicated in a variety of immunological and inflammatory response cascades. Further understanding of FPR-family ligand interactions could play an integral role in biological and therapeutic discovery. Fluorescent r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7d636005887fef6c3dcce236c6a4cc4
https://doi.org/10.1002/cyto.a.20670
https://doi.org/10.1002/cyto.a.20670
Autor:
Colleen B. Jonsson, Frederick Tapaha, Marjan Jeselnik, Jeffrey B. Arterburn, J. Jacob Strouse, William B. Parker
Publikováno v:
Tetrahedron Letters. 46:5699-5702
The synthesis of a series of N1-aryl inosine and guanosine derivatives is described. The procedure for chemoselective N1-arylation involves the mild oxidative copper(II) mediated coupling with boronic acids. This approach provides access to substitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75a644f64f506ec42c9bc09f70c1106e
https://doi.org/10.1016/j.tetlet.2005.06.083
https://doi.org/10.1016/j.tetlet.2005.06.083
Autor:
J. Jacob Strouse, Larry A. Sklar, George P. Tegos, Oleg Ursu, Annette M. Evangelisti, Cristian Bologa
Publikováno v:
Drug discovery today. Technologies. 12
This review highlights the concepts, recent applications and limitations of High Throughput Screening (HTS) flow cytometry-based efflux inhibitory assays. This platform has been employed in mammalian and yeast efflux systems leading to the identifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2822679ef61853d353af2ed914b4d1
https://pubmed.ncbi.nlm.nih.gov/25027381
https://pubmed.ncbi.nlm.nih.gov/25027381