Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jacob Spinnen"'
Autor:
Laurens Roolfs, Vanessa Hubertus, Jacob Spinnen, Lennard K. Shopperly, Michael G. Fehlings, Peter Vajkoczy
Publikováno v:
Neurospine, Vol 19, Iss 4, Pp 961-975 (2022)
Traumatic spinal cord injury (SCI) disrupts the spinal cord vasculature resulting in ischemia, amplification of the secondary injury cascade and exacerbation of neural tissue loss. Restoring functional integrity of the microvasculature to prevent neu
Externí odkaz:
https://doaj.org/article/e55dcbbc14fd4ad5abc45b6deaa7e1aa
Autor:
Ewa Wisniewska, Dominik Laue, Jacob Spinnen, Leonard Kuhrt, Benjamin Kohl, Patricia Bußmann, Carola Meier, Gundula Schulze-Tanzil, Wolfgang Ertel, Michal Jagielski
Publikováno v:
Cells, Vol 12, Iss 24, p 2850 (2023)
Osteoarthritis (OA) most frequently affects the knee joint and is associated with an elevated expression of cytokines and extracellular cartilage matrix (ECM), degrading enzymes such as matrix metalloproteinases (MMPs). Differences in gene expression
Externí odkaz:
https://doaj.org/article/0577b15e6d0a4188ab9205d56ed7345e
Autor:
Jacob Spinnen, Lennard K. Shopperly, Carsten Rendenbach, Anja A. Kühl, Ufuk Sentürk, Daniel Kendoff, Shabnam Hemmati-Sadeghi, Michael Sittinger, Tilo Dehne
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6394 (2021)
For in vitro modeling of human joints, osteochondral explants represent an acceptable compromise between conventional cell culture and animal models. However, the scarcity of native human joint tissue poses a challenge for experiments requiring high
Externí odkaz:
https://doaj.org/article/a7f592088a9546bfac8ed9fa87043d10
Autor:
Anna-Klara Amler, Patrick H. Dinkelborg, Domenic Schlauch, Jacob Spinnen, Stefan Stich, Roland Lauster, Michael Sittinger, Susanne Nahles, Max Heiland, Lutz Kloke, Carsten Rendenbach, Benedicta Beck-Broichsitter, Tilo Dehne
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 796 (2021)
Reconstruction of segmental bone defects by autologous bone grafting is still the standard of care but presents challenges including anatomical availability and potential donor site morbidity. The process of 3D bioprinting, the application of 3D prin
Externí odkaz:
https://doaj.org/article/5526d70f95bc4b49ab122dcddf9383ab
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 2023:1-18
Treatment options for critically sized bone defects are currently limited to metal osteosynthesis, autologous bone grafting, or calcium-based implants to bridge the gap. Additive manufacturing techniques pose a possible alternative. The light-basedth
Autor:
Lennard K. Shopperly, Jacob Spinnen, Jan‐Philipp Krüger, Michaela Endres, Michael Sittinger, Tobias Lam, Lutz Kloke, Tilo Dehne
Publikováno v:
Journal of biomedical materials research. Part B, Applied biomaterialsREFERENCES. 110(10)
Stereolithographic bioprinting holds great promise in the quest for creating artificial, biomimetic cartilage-like tissue. To introduce a more biomimetic approach, we examined blending and stratifying methacrylated hyaluronic acid (HAMA) and methacry
Autor:
Jacob Spinnen, Carsten Rendenbach, Anja Kühl, Ufuk Sentürk, Daniel Kendoff, Henrik Mei, Michael Sittinger, Tilo Dehne
Background: Current advances in musculoskeletal research yielded numerous new insights and therapy options for diseases of the joints but preclinical in-vitro testing is currently limited to self-manufactured 2D and 3D cell cultures only remotely mim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e085460e808d8d052d37dea5774da5a5
https://doi.org/10.21203/rs.3.rs-68789/v1
https://doi.org/10.21203/rs.3.rs-68789/v1